FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\UvragUAS.Tag:FLAG
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General Information
Symbol
Dmel\UvragUAS.Tag:FLAG
Species
D. melanogaster
Name
FlyBase ID
FBal0264047
Feature type
allele
Associated gene
Dmel\Uvrag
Associated Insertion(s)
Carried in Construct
P{UAS-Uvrag.Flag}
Key Links
Transgenic product class
cDNA
(Lee et al., 2011)
wild_type
(Lee et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Lee et al., 2011)
wild_type
(Lee et al., 2011)
Mutagen
in vitro construct
(Lee et al., 2011)
Progenitor genotype
Carried in construct
P{UAS-Uvrag.Flag}
Cytology
Description

UAS drives expression of the full length Uvrag cDNA (LD05963) tagged with Tag:FLAG.

(Lee et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Uvrag
Tagged with
Tag:FLAG
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In 3h-starved third instar larvae, fat body clones expressing UvragUAS.Tag:FLAG under the control of Scer\GAL4Act.PU exhibit a chain-like network of lysosomes, autolysosomes and autophagosomes, and display smaller late endosomes/lysosomes,

      (Takáts et al., 2021)

      The expression of UvragUAS.Tag:FLAG under the control of Scer\GAL4esg-NP5130 does not significantly affect the number of stem cells/enteroblasts in the adult midgut compared to controls.

      (Nagy et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4NP5130/UvragUAS.Tag:FLAG rescues UvragB21

      (Nagy et al., 2016)

      Scer\GAL4NP5130/UvragUAS.Tag:FLAG rescues UvragLL03097

      (Nagy et al., 2016)

      UvragUAS.Tag:FLAG/Scer\GAL4Abd-B-LDN rescues UvragKG04163/UvragB21

      (Lee et al., 2011)

      Scer\GAL4hs.PU/UvragUAS.Tag:FLAG rescues UvragKG04163/UvragB21

      (Lee et al., 2011)

      Scer\GAL4da.G32/UvragUAS.Tag:FLAG rescues UvragB21

      (Lee et al., 2011)
      Fails to rescue

      Scer\GAL4elav.PU/UvragUAS.Tag:FLAG fails to rescue UvragKG04163/UvragB21

      (Lee et al., 2011)

      Scer\GAL4Lsp2.PH/UvragUAS.Tag:FLAG fails to rescue UvragKG04163/UvragB21

      (Lee et al., 2011)
      Comments

      The expression of UvragUAS.Tag:FLAG under the control of Scer\GAL4esg-NP5130 suppresses the increased cell number observed in either UvragLL03097 or UvragB21 adult midgut clones.

      (Nagy et al., 2016)

      Ubiquitous expression of UvragScer\UAS.T:Zzzz\FLAG using Scer\GAL4da.G32 rescues the lethality of UvragB21 homozygotes.

      Expression of UvragScer\UAS.T:Zzzz\FLAG using Scer\GAL4Abd-B-LDN, but not Scer\GAL4elav.PU or Scer\GAL4Lsp2.PH, rescues the genital rotation defect of UvragKG04163/UvragB21 males.

      Heat-shock induced expression of UvragScer\UAS.T:Zzzz\FLAG using Scer\GAL4hs.PU, induced by a heat shock on day 7 +/- 2 days (late larval to early pupal stages), is sufficient to rescue the genital rotation defect of UvragKG04163/UvragB21 males.

      (Lee et al., 2011)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      UvragScer\UAS.T:Zzzz\FLAG
      UvragUAS.Tag:FLAG
      Name Synonyms
      Secondary FlyBase IDs
        References (3)