FlyBase Allele Report: Dmel\zyd[1]

General Information

Symbol

Dmel\zyd¹

Species

D. melanogaster

Name

FlyBase ID

FBal0265774

Feature type

allele

Associated gene

Dmel\zyd

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Melom and Littleton, 2013)

Progenitor genotype

Cytology

Description

Amino acid replacement: W475term.

(Melom and Littleton, 2013)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of epilepsy

CEA

(Weiss et al., 2019)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of epilepsy

is ameliorated by CanA-14F^GD14690

(Weiss et al., 2019)

is ameliorated by CanA-14F^HMS01880

(Weiss et al., 2019)

is ameliorated by Rab5^HMS00147

(Weiss et al., 2019)

is ameliorated by Rab5^S43N.UAS

(Weiss et al., 2019)

is ameliorated by Sh^{EKO.UAS.GFP(GL)}

(Weiss et al., 2019)

is ameliorated by cac^KK101478

(Weiss et al., 2019)

is ameliorated by sand^UAS.EGFP

(Weiss et al., 2019)

is ameliorated by CanB^GD10703

(Weiss et al., 2019)

is ameliorated by CanB^GD17823

(Weiss et al., 2019)

is ameliorated by CanB^JF02616

(Weiss et al., 2019)

is ameliorated by CanB2^GD13435

(Weiss et al., 2019)

is ameliorated by CanB2^JF02583

(Weiss et al., 2019)

is ameliorated by shi^ts.UAS.cUa

(Weiss et al., 2019)

is ameliorated by CanB2^KK107988

(Weiss et al., 2019)

is ameliorated by CanB2^KO

(Weiss et al., 2019)

is ameliorated by EndoA^GD7681

(Weiss et al., 2019)

is ameliorated by EndoA^JF02758

(Weiss et al., 2019)

is ameliorated by Pp2B-14D^DN.UASp

(Weiss et al., 2019)

is ameliorated by Pp2B-14D^HMS02039

(Weiss et al., 2019)

is ameliorated by Pp2B-14D^JF01949

(Weiss et al., 2019)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Homozygotes show rapid seizures upon exposure to 38[o]C. Homozygous larvae also show seizures at 38[o]C and the central pattern generator output from the neuromuscular junction shows rapid, unpatterned firing, in contrast to controls, which retain motor neuron bursting necessary for normal crawling behaviour.

At room temperature, homozygous, hemizygous, zyd¹/zyd² and zyd¹/zyd³ adults show a bang-sensitive phenotype (seizures and temporary paralysis in response to brief vortexing).

Homozygotes show robust seizures after a brief period of anesthesia on ice.

(Melom and Littleton, 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

zyd¹ has abnormal neurophysiology | third instar larval stage | heat sensitive phenotype, suppressible by Cam^HMS01318/Scer\GAL4^repo

(Melom and Littleton, 2013)

zyd¹ has abnormal behavior | recessive | adult stage | heat sensitive phenotype, suppressible by Cam^HMS01318/Scer\GAL4^repo

(Melom and Littleton, 2013)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

The temperature-sensitive seizure phenotype of zyd¹ larvae and adults is completely suppressed by expression of Cam^HMS01318 under the control of Scer\GAL4^repo.

(Melom and Littleton, 2013)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

zyd¹ is rescued by zyd^UAS.cMa/Scer\GAL4^repo

(Melom and Littleton, 2013)

zyd¹ is rescued by zyd^UAS.cMa/Scer\GAL4^NP2222

(Melom and Littleton, 2013)

zyd¹ is rescued by zyd^UAS.cMa/Scer\GAL4^nrv2.PS

(Melom and Littleton, 2013)

zyd¹ is rescued by zyd^UAS.cMa/Scer\GAL4^NP1243

(Melom and Littleton, 2013)

Not rescued by

zyd¹ is not rescued by zyd^UAS.cMa/Scer\GAL4^alrm.PD

(Melom and Littleton, 2013)

zyd¹ is not rescued by Scer\GAL4^elav-C155/zyd^UAS.cMa

(Melom and Littleton, 2013)

Comments

Expression of zyd^Scer\UAS.cMa under the control of Scer\GAL4^repo rescues temperature-sensitives seizures in zyd¹ mutants, but expression under the control of Scer\GAL4^elav-C155 does not.

Expression of zyd^Scer\UAS.cMa under the control of either Scer\GAL4^{Akap200-NP2222}, Scer\GAL4^nrv2.PS or Scer\GAL4^wun-NP1243 rescues temperature-sensitives seizures in zyd¹ mutants.

Expression of zyd^Scer\UAS.cMa under the control of Scer\GAL4^alrm.PD fails to rescue temperature-sensitives seizures in zyd¹ mutants.

(Melom and Littleton, 2013)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

zyd¹

(Weiss et al., 2022, Weiss et al., 2019)

zydeco¹

Name Synonyms

zydeco

(Guan et al., 2011)

Secondary FlyBase IDs

References (4)

Report Sections

Open Close