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General Information
Symbol
Dmel\par-1UAS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0265783
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-PAR-1
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of the par-1 α isoform tagged with Tag:MYC.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of par-1Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4GMR.PF causes age-dependent and progressive neurodegeneration in the lamina; degeneration in the lamina is undetectable in flies at 3-day old, but is prominent at 10 days old.

Expression of par-1Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4ey-OK107 disrupts the formation of mushroom body α/β lobes. Abnormal β lobes are more common than disrupted α lobes.

Expression of par-1Scer\UAS.T:Hsap\MYC in the eye under the control of Scer\GAL4GMR.PF causes degeneration.

Expression of par-1Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4GMR.PF causes eye degeneration.

Expression of par-1Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4GMR.PF causes eye degeneration.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
NOT Enhanced by
Statement
Reference
Suppressed by
Other
Additional Comments
Genetic Interactions
Statement
Reference

Co-expression of par-1Scer\UAS.T:Hsap\MYC and miltGD8116 under the control of Scer\GAL4GMR.PF causes prominent neurodegeneration in the lamina at 3 days old.

Co-expression of lkb1Scer\UAS.cWa enhances the eye degeneration seen when par-1Scer\UAS.T:Hsap\MYC is expressed under the control of Scer\GAL4GMR.PF.

Co-expression of lkb1dsRNA.Scer\UAS.cWa suppresses the eye degeneration seen when par-1Scer\UAS.T:Hsap\MYC is expressed under the control of Scer\GAL4GMR.PF.

Xenogenetic Interactions
Statement
Reference

Expression of lokScer\UAS.cPa does not enhance the eye degeneration phenotype seen when par-1Scer\UAS.T:Hsap\MYC is expressed under the control of Scer\GAL4GMR.PF.

Expression of Hsap\APP695.T.Scer\UAS enhances the rough eye phenotype seen when par-1Scer\UAS.T:Hsap\MYC is expressed under the control of Scer\GAL4GMR.PF.

Expression of lkb1dsRNA.Scer\UAS.cWa suppresses the rough eye phenotype seen when par-1Scer\UAS.T:Hsap\MYC and Hsap\APP695.T.Scer\UAS are co-expressed under the control of Scer\GAL4GMR.PF.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
par-1Scer\UAS.T:Hsap\MYC
par-1UAS.Tag:MYC
Name Synonyms
Secondary FlyBase IDs
    References (6)