FlyBase Allele Report: Dmel\bsk[NIG.5680R]

General Information

Symbol

Dmel\bsk^NIG.5680R

Species

D. melanogaster

Name

FlyBase ID

FBal0267344

Feature type

allele

Associated gene

Dmel\bsk

Associated Insertion(s)

Carried in Construct

P{NIG.5680R}

Also Known As

UAS-bsk-IR, UAS-bsk^RNAi, 5680R

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Tsuzuki et al., 2012)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Tsuzuki et al., 2012)

Mutagen

in vitro construct

(Tsuzuki et al., 2012)

Progenitor genotype

Carried in construct

P{NIG.5680R}

Cytology

Description

UASt regulatory sequences drive expression of a bsk RNAi line.

(Tsuzuki et al., 2012)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-5680R

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates human immunodeficiency virus infectious disease

modeled by HIV-1\Vpu^UAS.cLa

(Marchal et al., 2012)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased occurrence of cell division | conditional, with Scer\GAL4^esg.PU, Scer\GAL4^mex1.PU

(Geng et al., 2025)

Phenotype Manifest In

midgut | conditional, with Scer\GAL4^esg.PU, Scer\GAL4^mex1.PU

(Geng et al., 2025)

Detailed Description

Statement

Reference

Expression of bsk^NIG.5680R under the control of Scer\GAL4^e22c does not induce formation of syncytia in third instar larval epidermis.

(Wang et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

bsk^NIG.5680R, Scer\GAL4^GMR.PU is a non-enhancer of visible | adult stage | progressive phenotype of Hsap\ATXN3^{fl.Q78.UAS.Tag:MYC}, Scer\GAL4^GMR.PU

(Vinatier et al., 2015)

bsk^NIG.5680R, Scer\GAL4^GMR.PU is a non-enhancer of abnormal eye color | progressive phenotype of Hsap\ATXN3^{fl.Q78.UAS.Tag:MYC}, Scer\GAL4^GMR.PU

(Vinatier et al., 2015)

Suppressor of

Statement

Reference

bsk^NIG.5680R/Scer\GAL4^GMR.PU is a suppressor | partially of abnormal size | adult stage phenotype of Scer\GAL4^GMR.PU, egr^GS9830

(Ren et al., 2017)

bsk^NIG.5680R/Scer\GAL4^GMR.PU is a suppressor | partially of visible | adult stage phenotype of Scer\GAL4^GMR.PU, egr^GS9830

(Ren et al., 2017)

bsk^NIG.5680R/Scer\GAL4^GMR.PU is a suppressor | partially of increased cell death | third instar larval stage phenotype of Scer\GAL4^GMR.PU, egr^GS9830

(Ren et al., 2017)

Scer\GAL4^ptc-559.1/bsk^NIG.5680R is a suppressor | partially of increased cell death | third instar larval stage phenotype of Scer\GAL4^ptc-559.1, egr^GS9830

(Ren et al., 2017)

bsk^NIG.5680R/Scer\GAL4^GMR.PU is a suppressor | partially of abnormal size | adult stage phenotype of Scer\GAL4^GMR.PU, hep^CA.UAS

(Ren et al., 2017)

bsk^NIG.5680R/Scer\GAL4^GMR.PU is a suppressor | partially of visible | adult stage phenotype of Scer\GAL4^GMR.PU, hep^CA.UAS

(Ren et al., 2017)

bsk^NIG.5680R/Scer\GAL4^GMR.PU is a suppressor | partially of increased cell death | third instar larval stage phenotype of Scer\GAL4^GMR.PU, hep^CA.UAS

(Ren et al., 2017)

Scer\GAL4^ptc-559.1/bsk^NIG.5680R is a suppressor | partially of increased cell death | third instar larval stage phenotype of Scer\GAL4^ptc-559.1, hep^CA.UAS

(Ren et al., 2017)

bsk^NIG.5680R, Scer\GAL4^vg.PM is a suppressor | partially of visible phenotype of Rbf^D253A.UAS, Scer\GAL4^vg.PM

(Milet et al., 2014)

bsk^NIG.5680R, Scer\GAL4^vg.PM is a suppressor | partially of visible phenotype of Rbf^UAS.cDa, Scer\GAL4^vg.PM

(Milet et al., 2014)

bsk^NIG.5680R, Scer\GAL4^dpp.blk1 is a suppressor of visible phenotype of HIV-1\Vpu^UAS.cLa, Scer\GAL4^dpp.blk1

(Marchal et al., 2012)

NOT Suppressor of

Statement

Reference

bsk^NIG.5680R, Scer\GAL4^GMR.PU is a non-suppressor of visible | adult stage | progressive phenotype of Hsap\ATXN3^{fl.Q78.UAS.Tag:MYC}, Scer\GAL4^GMR.PU

(Vinatier et al., 2015)

bsk^NIG.5680R, Scer\GAL4^GMR.PU is a non-suppressor of abnormal eye color | progressive phenotype of Hsap\ATXN3^{fl.Q78.UAS.Tag:MYC}, Scer\GAL4^GMR.PU

(Vinatier et al., 2015)

bsk^NIG.5680R/Scer\GAL4^e22c is a non-suppressor of abnormal cell shape | third instar larval stage phenotype of Scer\GAL4^e22c, stck^NIG.7954R

(Wang et al., 2015)

bsk^NIG.5680R/Scer\GAL4^e22c is a non-suppressor of increased cell size | third instar larval stage phenotype of Scer\GAL4^e22c, stck^NIG.7954R

(Wang et al., 2015)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

bsk^NIG.5680R, Scer\GAL4^GMR.PU is a non-enhancer of eye | progressive phenotype of Hsap\ATXN3^{fl.Q78.UAS.Tag:MYC}, Scer\GAL4^GMR.PU

(Vinatier et al., 2015)

Suppressor of

Statement

Reference

bsk^NIG.5680R/Scer\GAL4^GMR.PU is a suppressor | partially of eye phenotype of Scer\GAL4^GMR.PU, egr^GS9830

(Ren et al., 2017)

bsk^NIG.5680R/Scer\GAL4^GMR.PU is a suppressor | partially of eye disc morphogenetic furrow | third instar larval stage phenotype of Scer\GAL4^GMR.PU, egr^GS9830

(Ren et al., 2017)

Scer\GAL4^ptc-559.1/bsk^NIG.5680R is a suppressor | partially of anterior-posterior compartment boundary of the wing disc | third instar larval stage phenotype of Scer\GAL4^ptc-559.1, egr^GS9830

(Ren et al., 2017)

Scer\GAL4^ptc-559.1/bsk^NIG.5680R is a suppressor | partially of anterior crossvein | third instar larval stage phenotype of Scer\GAL4^ptc-559.1, egr^GS9830

(Ren et al., 2017)

bsk^NIG.5680R/Scer\GAL4^GMR.PU is a suppressor | partially of eye phenotype of Scer\GAL4^GMR.PU, hep^CA.UAS

(Ren et al., 2017)

bsk^NIG.5680R/Scer\GAL4^GMR.PU is a suppressor | partially of eye disc morphogenetic furrow | third instar larval stage phenotype of Scer\GAL4^GMR.PU, hep^CA.UAS

(Ren et al., 2017)

Scer\GAL4^ptc-559.1/bsk^NIG.5680R is a suppressor | partially of anterior-posterior compartment boundary of the wing disc | third instar larval stage phenotype of Scer\GAL4^ptc-559.1, hep^CA.UAS

(Ren et al., 2017)

Scer\GAL4^ptc-559.1/bsk^NIG.5680R is a suppressor | partially of anterior crossvein | third instar larval stage phenotype of Scer\GAL4^ptc-559.1, hep^CA.UAS

(Ren et al., 2017)

bsk^NIG.5680R, Scer\GAL4^vg.PM is a suppressor | partially of wing phenotype of Rbf^UAS.cDa, Scer\GAL4^vg.PM

(Milet et al., 2014)

bsk^NIG.5680R, Scer\GAL4^vg.PM is a suppressor | partially of wing phenotype of Rbf^D253A.UAS, Scer\GAL4^vg.PM

(Milet et al., 2014)

bsk^NIG.5680R, Scer\GAL4^vg.PM is a suppressor | partially of wing disc phenotype of Rbf^D253A.UAS, Scer\GAL4^vg.PM

(Milet et al., 2014)

bsk^NIG.5680R, Scer\GAL4^dpp.blk1 is a suppressor of wing phenotype of HIV-1\Vpu^UAS.cLa, Scer\GAL4^dpp.blk1

(Marchal et al., 2012)

NOT Suppressor of

Statement

Reference

bsk^NIG.5680R, Scer\GAL4^GMR.PU is a non-suppressor of eye | progressive phenotype of Hsap\ATXN3^{fl.Q78.UAS.Tag:MYC}, Scer\GAL4^GMR.PU

(Vinatier et al., 2015)

bsk^NIG.5680R/Scer\GAL4^e22c is a non-suppressor of embryonic/larval epidermis | third instar larval stage phenotype of Scer\GAL4^e22c, stck^NIG.7954R

(Wang et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

The expression of bsk^NIG.5680R partially suppresses both the eye-related phenotypes (i.e. increased apoptosis at the morphogenetic furrow of the third instar larval eye disc and the decreased eye size in adults) and the wing-related phenotypes (i.e. increased apoptosis around the anterior-posterior compartment boundary of the third instar larval wing disc and the highly penetrant anterior crossvein loss in the adult wing) resulting from the expression of egr^GS9830 or hep^CA.Scer\UAS under the control of Scer\GAL4^GMR.PU (eye phenotypes) or Scer\GAL4^ptc-559.1 (wing phenotypes).

(Ren et al., 2017)

The formation of abnormal large syncytia in larval epidermis characteristic for third instar larvae expressing stck^NIG.7954R under the control of Scer\GAL4^e22c is not suppressed by co-expression of any of bsk^NIG.5680R.

(Wang et al., 2015)

Expression of bsk^NIG.5680R partially suppresses the wing phenotypes seen when Rbf^Scer\UAS.cDa is expressed under the control of Scer\GAL4^vg.PM.

Expression of bsk^NIG.5680R partially suppresses the ectopic wing tissue and wing disc apoptosis seen when Rbf^{D253A.Scer\UAS} is expressed under the control of Scer\GAL4^vg.PM.

(Milet et al., 2014)

Xenogenetic Interactions

Statement

Reference

Co-expression of bsk^NIG.5680R suppresses the wing defects caused by expression of HIV-1\Vpu^Scer\UAS.cLa under the control of Scer\GAL4^dpp.blk1.

(Marchal et al., 2012)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

NIG-Fly

5680R-1

P{NIG.5680R}1

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

JNK^IR

(Brock et al., 2012)

JNK^RNAi

(Wang et al., 2015)

bsk^5680R-1

(Gonda et al., 2012)

bsk^5680R-2

(Vinatier et al., 2015)

bsk^NIG.5680R

Name Synonyms

Secondary FlyBase IDs

References (13)

Report Sections

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