FlyBase Allele Report: Dmel\gogo[DDD.UAS]

General Information

Symbol

Dmel\gogo^DDD.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0267395

Feature type

allele

Associated gene

Dmel\gogo

Associated Insertion(s)

Carried in Construct

P{UAS-gogo.DDD}

Key Links

Transgenic product class

missense_variant

(Mann et al., 2012)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Mann et al., 2012)

Mutagen

in vitro construct

(Mann et al., 2012)

Progenitor genotype

Carried in construct

P{UAS-gogo.DDD}

Cytology

Description

UAS regulatory sequences drive expression of a mutant form of gogo in which the YYD motif in the C2 cytoplasmic domain has been mutated to DDD.

(Mann et al., 2012)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

gogo

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy, with Scer\GAL4^GMR.PF

(Mann et al., 2012)

Phenotype Manifest In

medulla layer M1, with Scer\GAL4^GMR.PF

(Mann et al., 2012)

photoreceptor cell R8, with Scer\GAL4^GMR.PF

(Mann et al., 2012)

Detailed Description

Statement

Reference

Expression of gogo^DDD.Scer\UAS under the control of Scer\GAL4^GMR.PF results in premature stopping of R8 axons at the M1 medulla layer. Targeting of R7 neurons is normal.

(Mann et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^GMR.PF, gogo^DDD.UAS has abnormal neuroanatomy phenotype, enhanceable by InR^UAS.cHa, Scer\GAL4^GMR.PF

(Mann et al., 2012)

NOT Enhanced by

Statement

Reference

Scer\GAL4^GMR.PF, gogo^DDD.UAS has abnormal neuroanatomy phenotype, non-enhanceable by InR^K1409A.UAS, Scer\GAL4^GMR.PF

(Mann et al., 2012)

NOT suppressed by

Statement

Reference

Scer\GAL4^GMR.PF, gogo^DDD.UAS has abnormal neuroanatomy phenotype, non-suppressible by InR^K1409A.UAS, Scer\GAL4^GMR.PF

(Mann et al., 2012)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^GMR.PF, gogo^DDD.UAS has photoreceptor cell R8 phenotype, enhanceable by InR^UAS.cHa, Scer\GAL4^GMR.PF

(Mann et al., 2012)

Scer\GAL4^GMR.PF, gogo^DDD.UAS has medulla layer M1 phenotype, enhanceable by InR^UAS.cHa, Scer\GAL4^GMR.PF

(Mann et al., 2012)

NOT Enhanced by

Statement

Reference

Scer\GAL4^GMR.PF, gogo^DDD.UAS has photoreceptor cell R8 phenotype, non-enhanceable by InR^K1409A.UAS, Scer\GAL4^GMR.PF

(Mann et al., 2012)

Scer\GAL4^GMR.PF, gogo^DDD.UAS has medulla layer M1 phenotype, non-enhanceable by InR^K1409A.UAS, Scer\GAL4^GMR.PF

(Mann et al., 2012)

NOT suppressed by

Statement

Reference

Scer\GAL4^GMR.PF, gogo^DDD.UAS has photoreceptor cell R8 phenotype, non-suppressible by InR^K1409A.UAS, Scer\GAL4^GMR.PF

(Mann et al., 2012)

Scer\GAL4^GMR.PF, gogo^DDD.UAS has medulla layer M1 phenotype, non-suppressible by InR^K1409A.UAS, Scer\GAL4^GMR.PF

(Mann et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of stan^Scer\UAS.cUa and gogo^FFD.Scer\UAS under the control of Scer\GAL4^GMR.PF does not induce mistargeting of R7 photoreceptor cells to the R8 recipient layer (M3).

Expression of InR^{K1409A.Scer\UAS} does not affect the R8 axon stopping phenotype seen when gogo^DDD.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PF.

Expression of InR^Scer\UAS.cHa slightly enhances the R8 axon stopping phenotype seen when gogo^DDD.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PF.

(Mann et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

gogo^DDD.Scer\UAS

gogo^DDD.UAS

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

Open Close