transmembrane receptor that is dynamically expressed in all photoreceptor neurons and localizes predominantly to growth cones - regulates axon-axon and axon-target interactions in R8 photoreceptor axon - acts as a functional partner of Flamingo for R8 photoreceptor axon targeting in the medulla
Gene model reviewed during 5.45
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\gogo using the Feature Mapper tool.
gogo mRNA in the eye disc region posterior to the morphogenetic furrow is expressed in a dotted manner, corresponding to the nascent R8 cells.
gogo transcipts were observed in third instar larvae in eye-antennal discs. They are expressed in developing photoreceptors posterior to the morphogenetic furrow. In the optic lobe gogo is expressed in a crescent surrounding the optic lobe center. gogo localizes predominantly along the axon and growth cones of R7 and R8 photoreceptors.
Expression of gogo protein is found in the tips of the R7 and/or R8 axons of third instar larvae through to at least 72hrs APF.
gogo protein is detected in the optic lobe and the retina in 24APF pupa. Strong expression is observed in the lamina and the medulla. gogo protein localizes to the termini of photoreceptor neurons and is most abundant in R7 and R8 termini. gogo protein shows strong stainingin R1-R6 axons during lamina cartridge formation. Overall gogo expression is reduced by 48APF.
GBrowse - Visual display of RNA-Seq signalsView Dmel\gogo in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: gogo CG32227
Source for merge of: CG13815 CG13817
Annotations CG13815 and CG13817 merged as CG32227 in release 3 of the genome annotation.
Eye-specific mosaic larvae of gogo show an abnormal overall structure with clumpings of axons bundles and the presence of gaps in the lamina and the medulla. In the adult fly pathfinding of R8s is disrupted, as neighboring R8s cross each other. In addition, target recognition is affected, as R8s inappropriately target the R7 layer.