FlyBase Allele Report: Dmel\gogo[D1600]

General Information

Symbol

Dmel\gogo^D1600

Species

D. melanogaster

Name

FlyBase ID

FBal0242620

Feature type

allele

Associated gene

Dmel\gogo

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Tomasi et al., 2008)

Mutagen

ethyl methanesulfonate

(Berger et al., 2008)

Progenitor genotype

Cytology

Description

Nucleotide substitution: T?C.

(Berger et al., 2008)

A mutation in the splice donor site for intron 5 is mutated leading to a premature STOP before the transmembrane domain.

(Berger et al., 2008)

Mutation in a splice donor site, resulting in a frameshift after amino acid residue 573, with 28 amino acids added after the frameshift.

(Tomasi et al., 2008)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:20,272,985..20,272,985 [-]

Nucleotide change:

T20272985C

Reported nucleotide change:

T?C

Comment:

T to C mutation in splice donor site.

(Tomasi et al., 2008)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | late embryonic stage (with gogo^H1675)

(Stratmann et al., 2019)

abnormal neuroanatomy | somatic clone | third instar larval stage

(Berger et al., 2008)

Phenotype Manifest In

apterous-expressing neuron of the lateral cluster of the thorax | late embryonic stage (with gogo^H1675)

(Stratmann et al., 2019)

photoreceptor neuron (with gogo^D869)

(Tomasi et al., 2008)

photoreceptor neuron | somatic clone

(Tomasi et al., 2008)

Detailed Description

Statement

Reference

In gogo^H1675/gogo^D1600 embryos the axons of ap-expressing neurons are mildly disorganized, with no impact on the overall organization of the Fas2-immunopositive scaffold.

(Stratmann et al., 2019)

Photoreceptor axons do not project correctly in the optic lobe of gogo^D1600 eye-brain complexes in third instar larvae, while the photoreceptor cells themselves are appropriately specified.

(Berger et al., 2008)

All photoreceptors are present and properly located in tangential sections of the eye in animals in which the retina is homozygous (induced using the eyFLP method), but these animals show defects in the projections of photoreceptor axons.

gogo^D869/gogo^D1600 adult escapers show defects in the projection of photoreceptor axons.

(Tomasi et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference