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General Information
Symbol
Dmel\gogoH1675
Species
D. melanogaster
Name
FlyBase ID
FBal0242621
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
H1675
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

C20278247T

Reported nucleotide change:

C?T

Amino acid change:

Q255term | gogo-PA

Reported amino acid change:

Q255term

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid numbering based on PA isoform.

Amino acid replacement: Q255term.

Amino acid replacement: Q255@.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

In gogoH1675/gogoD1600 embryos the axons of ap-expressing neurons are mildly disorganized, with no impact on the overall organization of the Fas2-immunopositive scaffold.

Homozygous gogoH1675 eyes (generated using the eyFLP system) display a severe phenotype, with incomplete medulla rotation and the formation of abnormal bundles through an ectopic chiasm.

Photoreceptor axons do not project correctly in the optic lobe of gogoH1675 eye-brain complexes in third instar larvae, while the photoreceptor cells themselves are appropriately specified.

All photoreceptors are present and properly located in tangential sections of the eye in animals in which the retina is homozygous (induced using the eyFLP method), but these animals show defects in the projections of photoreceptor axons.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

gogoH1675/+ substantially increases the incidence of R8 photoreceptor axon defects in mosaic animals containing homozygous stanE86 R8 photoreceptor axons.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescued by
Comments

Expression of gogoGMR.T:Hsap\MYC completely rescues the axon projection defects seen in gogoH1675 mutant eye clones.

Expression of gogoC2.GMR.T:Hsap\MYC completely rescues the axon projection defects seen in gogoH1675 mutant eye clones.

Expression of gogoC1.GMR.T:Hsap\MYC fails to rescue the axon projection defects seen in gogoH1675 mutant eye clones.

Expression of gogoC3.GMR.T:Hsap\MYC fails to rescue the axon projection defects seen in gogoH1675 mutant eye clones.

Expression of gogoC1C2.GMR.T:Hsap\MYC completely rescues the axon projection defects seen in gogoH1675 mutant eye clones.

Expression of gogoC2C3.GMR.T:Hsap\MYC completely rescues the axon projection defects seen in gogoH1675 mutant eye clones.

Expression of gogoC1C3.GMR.T:Hsap\MYC fails to rescue the axon projection defects seen in gogoH1675 mutant eye clones.

Expression of gogoΔYYD.GMR fails to rescue the axon projection defects seen in gogoH1675 mutant eye clones.

Expression of gogoFFD.GMR completely rescues the axon projection defects seen in gogoH1675 mutant eye clones.

Expression of gogoDDD.GMR fails to rescue the axon projection defects seen in gogoH1675 mutant eye clones.

Expression of gogoDYD.GMR fails to rescue the axon projection defects seen in gogoH1675 mutant eye clones.

Expression of gogoYDD.GMR fails to rescue the axon projection defects seen in gogoH1675 mutant eye clones.

Expression of gogoFYD.GMR completely rescues the axon projection defects seen in gogoH1675 mutant eye clones.

Expression of gogoYFD.GMR completely rescues the axon projection defects seen in gogoH1675 mutant eye clones.

Expression of gogoC2shortFFD.GMR rescues most of the phenotypes seen in gogoH1675 mutant eye clones. The medulla rotation is completely rescued, whereas the R8 targeting is only partially rescued (approximately 70% of R8 neurons target correctly).

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (6)