FB2026_02 , released June 18, 2026
Allele: Dmel\gogoD869
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General Information
Symbol
Dmel\gogoD869
Species
D. melanogaster
Name
FlyBase ID
FBal0242619
Feature type
allele
Associated gene
Dmel\gogo
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Tomasi et al., 2008)
Mutagen
ethyl methanesulfonate
(Berger et al., 2008)
Progenitor genotype
Cytology
Description

Nucleotide substitution: G?A.

(Berger et al., 2008)

A mutation in the splice donor site for intron 6 is mutated leading to a premature STOP before the transmembrane domain.

(Berger et al., 2008)

Mutation in a splice donor site, resulting in a frameshift after amino acid residue 669, with 2 amino acids added after the frameshift.

(Tomasi et al., 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:20,271,515..20,271,515 [-]
Nucleotide change:

G20271515A

Reported nucleotide change:

G?A

Comment:

G to A mutation in splice donor site.

(Tomasi et al., 2008)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Dendrites of multiple dendrite neurons overgrow in gogoD869/gogoH1675 embryos and 8.3% of the segments show dorsal midline crossing.

      (Hakeda-Suzuki et al., 2011)

      Photoreceptor axons do not project correctly in the optic lobe of gogoD869 eye-brain complexes in third instar larvae, while the photoreceptor cells themselves are appropriately specified.

      (Berger et al., 2008)

      Animals in which the retina is homozygous (induced using the eyFLP method) show a number of defects in all photoreceptor cell axon types. They show incomplete medulla rotation, combined with the formation of abnormal bundles through an ectopic chiasm at the posterior side of the lamina. The R1-R6 axons correctly target the lamina, but the overall lamina structure shows mild irregularities. The projection pattern of the R7 axons is generally disrupted, resulting in crossings of axons and a low frequency of undershooting the medulla layer M6. The R8 axons cross and bundle each other and often overshoot their correct target layer (M3) and mistarget to the R7 target layer M6. R8 axons are also seen to stall at the M1 layer (wild-type R8 axons temporarily stop at this layer in early pupae) and fail to innervate the medulla.

      gogoD869/gogoD1600 adult escapers show defects in the projection of photoreceptor axons.

      Homozygous photoreceptor cell R7 clones do not show an abnormal phenotype in their axons.

      Mutant axons in small homozygous clones of R7/R8 photoreceptor cells in larvae form bundles with neighbouring mutant axons (this bundling behaviour is not seen in wild-type clones). Wild-type axons adjacent to the homozygous clones barely seem affected. At the clone border, 71% of mutant R8 axons bind to another mutant R8 axon, whereas none bind to an adjacent wild-type R8 axon. Single isolated homozygous photoreceptor axons do not show any abnormalities.

      In adults containing small homozygous clones of R8 photoreceptor cells, disruption of the axonal array in the medulla is seen mostly within the clone. The mutant R8 axons sometimes tangle with each other. A few of the mutant R8 axons overshoot to the wrong layer of the medulla while many stop at the superficial layer M1. At the surface of the medulla, some mutant R8 axons turn aberrantly in the wrong direction towards the dorsal-ventral axis within the surface of the medulla, rather than turning and extending into the medulla.

      (Tomasi et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      gogo[+]/gogoD869 is an enhancer of larval multidendritic class IV neuron phenotype of stanE86

      (Hakeda-Suzuki et al., 2011)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      gogoD869/+ substantially increases the incidence of R8 photoreceptor axon defects in mosaic animals containing homozygous stanE86 R8 photoreceptor axons.

      The dorsal-midline crossing phenotype seen in class IV neurons of stanE86 embryos is enhanced by gogoD869/+ (midline crossing is seen in 29.6% of cases).

      (Hakeda-Suzuki et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      D869
      (Berger et al., 2008)
      gogoD869
      (Hakeda-Suzuki et al., 2011, Hakeda-Suzuki et al., 2011, Tomasi et al., 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)