FlyBase Allele Report: Dmel\Reph[k08617A]

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Allele: Dmel\Reph^k08617A

General Information

Symbol

Dmel\Reph^k08617A

Species

D. melanogaster

Name

FlyBase ID

FBal0269899

Feature type

allele

Associated gene

Associated Insertion(s)

P{lacW}Reph^k08617A

Carried in Construct

Key Links

Genomic Maps

Allele class

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

Mutagen

Delta2-3 transposase

(Dearborn et al., 2012)

Progenitor genotype

(Dearborn et al., 2012)

Associated Insertion(s)

P{lacW}Reph^k08617A

Cytology

Description

Mobilization of P{lacW}k08617 resulting in a new P{lacW} insertion in the first intron of the 2.1 kb Reph transcript-encoding region, upstream of the first exon of the 3.1 kb Reph transcript-encoding region.

(Dearborn et al., 2012)

Allele components

Component

Use(s)

Inserted element

Encoded product / tool

reporter enzyme

Tagged with

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2L:3,804,764..3,804,864

(Dearborn et al., 2012)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

distribution deduced from reporter

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

eye disc posterior to the morphogenetic furrow

(Dearborn et al., 2012)

eye disc morphogenetic furrow

(Dearborn et al., 2012)

(Dearborn et al., 2012)

(Dearborn et al., 2012)

Additional Information

Statement

Reference

Reph^k08617A drives expression posterior to and within the morphogenetic furrow in the eye disc. In the lamina, expression is the highest at the midline, decreasing along the dorsal-ventral axis. In the medulla, expression of Reph^k08617A decreases along the dorsal-ventral axis.

(Dearborn et al., 2012)

Marker for

Reflects expression of

(Dearborn et al., 2012)

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | embryonic stage

(Dearborn et al., 2012)

lethal - all die during embryonic stage

(Dearborn et al., 2012)

some die during embryonic stage

(Dearborn et al., 2012)

Phenotype Manifest In

lamina furrow | cell autonomous | somatic clone

(Dearborn et al., 2012)

larval longitudinal connective | embryonic stage

(Dearborn et al., 2012)

symmetrical commissure | embryonic stage

(Dearborn et al., 2012)

Detailed Description

Statement

Reference

Frequent defects in the ladder-like organization of commissural and longitudinal connectives are observed in homozygous embryos.

Photoreceptor axon projections near Reph^k08617A somatic clones are abnormal and the lamina furrow fails to extend ventrally through the clone.

(Dearborn et al., 2012)

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Reph^k08617A/Reph[+] is an enhancer of abnormal neuroanatomy | third instar larval stage phenotype of Ephrin^RS5

(Dearborn et al., 2012)

Reph^k08617A/Reph[+] is an enhancer of abnormal neuroanatomy | third instar larval stage phenotype of Eph^KD

(Dearborn et al., 2012)

Phenotype Manifest In

Enhancer of

Statement

Reference

Reph^k08617A/Reph[+] is an enhancer of lobula | third instar larval stage phenotype of Ephrin^RS5

(Dearborn et al., 2012)

Reph^k08617A/Reph[+] is an enhancer of lobula | third instar larval stage phenotype of Eph^KD

(Dearborn et al., 2012)

Reph^k08617A/Reph[+] is an enhancer of medulla anlage | third instar larval stage phenotype of Ephrin^RS5

(Bettencourt da Cruz et al., 2008)

Reph^k08617A/Reph[+] is an enhancer of medulla anlage | third instar larval stage phenotype of Eph^KD

(Bettencourt da Cruz et al., 2008)

Suppressor of

Statement

Reference

Reph^k08617A is a suppressor of eye phenotype of Ephrin^UAS.cDa, Scer\GAL4^hs.2sev

(Dearborn et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

The rough eye phenotype of Scer\GAL4^hs.2sev, Ephrin^Scer\UAS.cDa flies is strongly suppressed by Reph^k08617A.

All optic lobe phenotypic features associated with Ephrin^RS5 or Eph^KD are exacerbated by heterozygosity for Reph^k08617A.

(Dearborn et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Reph^k08617A

reph^K8617A

(Dearborn et al., 2012)

reph^k08617

(Dearborn et al., 2012)

reph^k8617A

(Dearborn et al., 2012)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections