FlyBase Allele Report: Dmel\Arf6[Q67L.UAS]

General Information

Symbol

Dmel\Arf6^Q67L.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0270075

Feature type

allele

Associated gene

Dmel\Arf6

Associated Insertion(s)

Carried in Construct

P{UAS-Arf6.Q67L}

Also Known As

UAS-Arf6^CA

Key Links

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Dottermusch-Heidel et al., 2012)

Progenitor genotype

Carried in construct

P{UAS-Arf6.Q67L}

Cytology

Description

UAS regulatory sequences drive expression of a constitutively active form of Arf51F.

(Dottermusch-Heidel et al., 2012)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Arf6

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy, with Scer\GAL4^Toll-6-D42

(Mallik et al., 2026)

abnormal neurophysiology | larval stage, with Scer\GAL4^Toll-6-D42

(Mallik et al., 2026)

abnormal size, with Scer\GAL4^Toll-6-D42

(Mallik et al., 2026)

Phenotype Manifest In

embryonic/larval neuromuscular junction | larval stage, with Scer\GAL4^Toll-6-D42

(Mallik et al., 2026)

NMJ bouton | decreased number, with Scer\GAL4^Toll-6-D42

(Mallik et al., 2026)

presynaptic active zone | increased number, with Scer\GAL4^Toll-6-D42

(Mallik et al., 2026)

synapse, with Scer\GAL4^Toll-6-D42

(Mallik et al., 2026)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Arf6^Q67L.UAS, Scer\GAL4^Toll-6-D42 has abnormal neuroanatomy phenotype, suppressible | partially by Plc21C^RNAi.UAS.cUa/Scer\GAL4^RapGAP1-OK6, Scer\GAL4^Toll-6-D42

(Mallik et al., 2026)

Arf6^Q67L.UAS, Scer\GAL4^Toll-6-D42 has abnormal neurophysiology | larval stage phenotype, suppressible by Plc21C^RNAi.UAS.cUa/Scer\GAL4^RapGAP1-OK6, Scer\GAL4^Toll-6-D42

(Mallik et al., 2026)

Arf6^Q67L.UAS, Scer\GAL4^Toll-6-D42 has abnormal neurophysiology | larval stage phenotype, suppressible by Scer\GAL4^RapGAP1-OK6/Itpr^RNAi.UAS.cUa, Scer\GAL4^Toll-6-D42

(Mallik et al., 2026)

Arf6^Q67L.UAS, Scer\GAL4^Toll-6-D42 has abnormal size phenotype, suppressible | partially by Scer\GAL4^RapGAP1-OK6/Itpr^RNAi.UAS.cUa, Scer\GAL4^Toll-6-D42

(Mallik et al., 2026)

Arf6^Q67L.UAS, Scer\GAL4^Toll-6-D42 has abnormal size phenotype, suppressible | partially by Plc21C^RNAi.UAS.cUa/Scer\GAL4^RapGAP1-OK6, Scer\GAL4^Toll-6-D42

(Mallik et al., 2026)

Arf6^Q67L.UAS, Scer\GAL4^Toll-6-D42 has abnormal neuroanatomy phenotype, suppressible | partially by Mmus\Itpr1^{IP3-sponge.m30.UAS}/Scer\GAL4^RapGAP1-OK6, Scer\GAL4^Toll-6-D42

(Mallik et al., 2026)

Arf6^Q67L.UAS, Scer\GAL4^Toll-6-D42 has abnormal neurophysiology | larval stage phenotype, suppressible by Mmus\Itpr1^{IP3-sponge.m30.UAS}/Scer\GAL4^RapGAP1-OK6, Scer\GAL4^Toll-6-D42

(Mallik et al., 2026)

Arf6^Q67L.UAS, Scer\GAL4^Toll-6-D42 has abnormal size phenotype, suppressible | partially by Mmus\Itpr1^{IP3-sponge.m30.UAS}/Scer\GAL4^RapGAP1-OK6, Scer\GAL4^Toll-6-D42

(Mallik et al., 2026)

Arf6^Q67L.UAS, Scer\GAL4^Toll-6-D42 has abnormal neuroanatomy phenotype, suppressible | partially by Scer\GAL4^RapGAP1-OK6/Itpr^RNAi.UAS.cUa, Scer\GAL4^Toll-6-D42

(Mallik et al., 2026)

NOT Enhancer of

Statement

Reference

Scer\GAL4^Toll-6-D42/Arf6^Q67L.UAS is a non-enhancer of abnormal neuroanatomy | larval stage phenotype of Df(2R)ED2076/Rab3^rup

(Mallik et al., 2026)

Scer\GAL4^Toll-6-D42/Arf6^Q67L.UAS is a non-enhancer of abnormal neuroanatomy phenotype of Asap^B52/Asap^K23

(Mallik et al., 2026)

Scer\GAL4^Toll-6-D42/Arf6^Q67L.UAS is a non-enhancer of abnormal size phenotype of Asap^B52/Asap^K23

(Mallik et al., 2026)

Scer\GAL4^Act5C.PI/Arf6^Q67L.UAS is a non-enhancer of abnormal neuroanatomy phenotype of Asap^B52/Asap^K23

(Mallik et al., 2026)

Scer\GAL4^Act5C.PI/Arf6^Q67L.UAS is a non-enhancer of abnormal size phenotype of Asap^B52/Asap^K23

(Mallik et al., 2026)

NOT Suppressor of

Statement

Reference

Scer\GAL4^Toll-6-D42/Arf6^Q67L.UAS is a non-suppressor of abnormal neuroanatomy | larval stage phenotype of Df(2R)ED2076/Rab3^rup

(Mallik et al., 2026)

Scer\GAL4^Toll-6-D42/Arf6^Q67L.UAS is a non-suppressor of abnormal neuroanatomy phenotype of Asap^B52/Asap^K23

(Mallik et al., 2026)

Scer\GAL4^Toll-6-D42/Arf6^Q67L.UAS is a non-suppressor of abnormal size phenotype of Asap^B52/Asap^K23

(Mallik et al., 2026)

Scer\GAL4^Act5C.PI/Arf6^Q67L.UAS is a non-suppressor of abnormal neuroanatomy phenotype of Asap^B52/Asap^K23

(Mallik et al., 2026)

Scer\GAL4^Act5C.PI/Arf6^Q67L.UAS is a non-suppressor of abnormal size phenotype of Asap^B52/Asap^K23

(Mallik et al., 2026)

Phenotype Manifest In

Suppressed by

Statement

Reference

Arf6^Q67L.UAS, Scer\GAL4^Toll-6-D42 has NMJ bouton | decreased number phenotype, suppressible | partially by Scer\GAL4^RapGAP1-OK6/Itpr^RNAi.UAS.cUa, Scer\GAL4^Toll-6-D42

(Mallik et al., 2026)

Arf6^Q67L.UAS, Scer\GAL4^Toll-6-D42 has NMJ bouton | decreased number phenotype, suppressible | partially by Plc21C^RNAi.UAS.cUa/Scer\GAL4^RapGAP1-OK6, Scer\GAL4^Toll-6-D42

(Mallik et al., 2026)

Arf6^Q67L.UAS, Scer\GAL4^Toll-6-D42 has embryonic/larval neuromuscular junction | larval stage phenotype, suppressible by Plc21C^RNAi.UAS.cUa/Scer\GAL4^RapGAP1-OK6, Scer\GAL4^Toll-6-D42

(Mallik et al., 2026)

Arf6^Q67L.UAS, Scer\GAL4^Toll-6-D42 has embryonic/larval neuromuscular junction | larval stage phenotype, suppressible by Scer\GAL4^RapGAP1-OK6/Itpr^RNAi.UAS.cUa, Scer\GAL4^Toll-6-D42

(Mallik et al., 2026)

Arf6^Q67L.UAS, Scer\GAL4^Toll-6-D42 has NMJ bouton | decreased number phenotype, suppressible | partially by Mmus\Itpr1^{IP3-sponge.m30.UAS}/Scer\GAL4^RapGAP1-OK6, Scer\GAL4^Toll-6-D42

(Mallik et al., 2026)

Arf6^Q67L.UAS, Scer\GAL4^Toll-6-D42 has embryonic/larval neuromuscular junction | larval stage phenotype, suppressible by Mmus\Itpr1^{IP3-sponge.m30.UAS}/Scer\GAL4^RapGAP1-OK6, Scer\GAL4^Toll-6-D42

(Mallik et al., 2026)

NOT Enhancer of

Statement

Reference

Scer\GAL4^Toll-6-D42/Arf6^Q67L.UAS is a non-enhancer of presynaptic active zone | larval stage | decreased number phenotype of Df(2R)ED2076/Rab3^rup

(Mallik et al., 2026)

Scer\GAL4^Toll-6-D42/Arf6^Q67L.UAS is a non-enhancer of NMJ bouton | decreased number phenotype of Asap^B52/Asap^K23

(Mallik et al., 2026)

Scer\GAL4^Act5C.PI/Arf6^Q67L.UAS is a non-enhancer of NMJ bouton | decreased number phenotype of Asap^B52/Asap^K23

(Mallik et al., 2026)

NOT Suppressor of

Statement

Reference

Scer\GAL4^Toll-6-D42/Arf6^Q67L.UAS is a non-suppressor of presynaptic active zone | larval stage | decreased number phenotype of Df(2R)ED2076/Rab3^rup

(Mallik et al., 2026)

Scer\GAL4^Toll-6-D42/Arf6^Q67L.UAS is a non-suppressor of NMJ bouton | decreased number phenotype of Asap^B52/Asap^K23

(Mallik et al., 2026)

Scer\GAL4^Act5C.PI/Arf6^Q67L.UAS is a non-suppressor of NMJ bouton | decreased number phenotype of Asap^B52/Asap^K23

(Mallik et al., 2026)

Scer\GAL4^twi.PG/Arf6^Q67L.UAS is a non-suppressor of embryonic myoblast phenotype of Iqsec^C1-28

(Dottermusch-Heidel et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of Arf51F^{Q67L.Scer\UAS} under the control of Scer\GAL4^twi.PG fails to rescue the defects in myoblast fusion seen in siz^C1-28 embryos.

(Dottermusch-Heidel et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Arf51F^{Q67L.Scer\UAS}

Arf51F^Q67L.UAS

Arf6^Q67L.UAS

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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