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General Information
Symbol
Dmel\tjNIG.10034R
Species
D. melanogaster
Name
FlyBase ID
FBal0270298
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-tjRNAi
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of a 500bp inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of tjNIG.10034R under the control of Scer\GAL4tj-NP1624 leads to ovary defects, with abnormally long terminal filaments and absence of cap cells, as compared to controls.

Compared with wild-type, expression of tjNIG.10034R under the control of Scer\GAL4slbo.2.6 delays border cell cluster migration by several hours in the ovary. Df(2L)E55/+ slightly enhances the migration defects in response to tjNIG.10034R.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Terminal filaments in ovaries from flies expressing tjNIG.10034R and NJF02959 under the control of Scer\GAL4tj-NP1624 are considerably shorter than those from flies expressing only tjNIG.10034R, although on average are still significantly longer than those in controls. Ovaries from flies expressing tjNIG.10034R and NJF02959 have a significant decrease in the number of terminal filaments, and some terminal filaments are unusually short with fewer than 7 cells.

Expression of both Nint.U.Scer\UAS and tjNIG.10034R under the control of Scer\GAL4tj-NP1624 leads to severe ovary defects. Most ovaries are extremely small, not connected to an oviduct and often attached to the gut, and consist largely of terminal filaments and a few germline cells embedded in fat body. The epithelial sheaths are missing and terminal filaments are located side-by-side. In the most severe cases, these ovaries consist only of terminal filaments. Terminal filaments in these flies are on average longer than those in flies expressing only Nint.U.Scer\UAS, but slightly shorter than those in flies expressing only tjNIG.10034R.

Exogenous shgScer\UAS.P\T.cSa expression fully suppresses the moderate migration delay caused by Scer\GAL4slbo.2.6>tjNIG.10034R.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
tjNIG.10034R
Name Synonyms
Secondary FlyBase IDs
    References (3)