FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\psidin55D4
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General Information
Symbol
Dmel\psidin55D4
Species
D. melanogaster
Name
FlyBase ID
FBal0277250
Feature type
allele
Associated gene
Dmel\psidin
Associated Insertion(s)
Carried in Construct
Also Known As
psid55D4
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Kim et al., 2011)
Progenitor genotype
Cytology
Description

Amino acid replacement: K471term.

(Kim et al., 2011)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:20,024,611..20,024,611 [+]
Nucleotide change:

A20024611T

Amino acid change:

K471term | psidin-PA

Reported amino acid change:

K471term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Kim et al., 2011)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  cancer
      modeled by Rbf15aΔ
      (Sheng and Du, 2020)
      modeled by Egfr2.A887T.UAS, scrib673
      (Sheng and Du, 2020)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous olfactory receptor neuron (ORN) clones result in complete loss of the Or33c and Or42a-expressing ORNs and a mild reduction in cell number of the Or67d, Or22a and Or59c ORNs.

      Homozygous ORN clones result in defects in glomerulus targeting. Mutant Or59c ORNs show a strong mistargeting phenotype.

      Neurons in primary neuron cultures derived from mutant embryos have significantly smaller lamellipodia and significantly longer neurites compared to wild-type controls.

      (Stephan et al., 2012)

      Homozygous border cells show defects in migration: many of the mutant cells show no migration at all, and more than 80% of mutant clusters fail to reach the oocyte by stage 10.

      Heterozygous border follicle cells have shorter actin-rich protrusions than controls.

      (Kim et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Enhancer of
      Statement
      Reference

      psidin55D4/psidin55D4 is an enhancer of increased cell death | larval stage | somatic clone phenotype of Rbf15aΔ

      (Sheng and Du, 2020)
      NOT Enhancer of
      Suppressor of
      NOT Suppressor of
      Other
      Phenotype Manifest In
      Suppressed by
      Enhancer of
      Statement
      Reference

      psidin55D4/psidin55D4 is an enhancer of eye disc | larval stage | somatic clone phenotype of Rbf15aΔ

      (Sheng and Du, 2020)
      NOT Enhancer of
      Suppressor of
      NOT Suppressor of
      Other
      Statement
      Reference

      Rbf15aΔ, psidin55D4 has wing disc | somatic clone phenotype

      (Sheng and Du, 2020)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Rbf15aΔ/Rbf15aΔ is synthetic lethal with psidin55D4/psidin55D4, as double mutant clones are not or rarely found in the eye; as consequence, eyes are smaller. Both phenotypes are exacerbated in a Minute background.

      Rbf15aΔ/Rbf15aΔ, psidin55D4/psidin55D4 double mutant clones in the wing disc show increased apoptosis.

      (Sheng and Du, 2020)

      The reduction in lamellipodia size and increase in neurite length which is seen in neurons in primary neuron cultures derived from psidin55D4 embryos are suppressed if the embryos are also mutant for Tm1ZCL0722.

      psidin55D4 Tm1ZCL0722 double mutant Or59c olfactory receptor neuron (ORNs) show a marked reduction in the penetrance and severity of axonal targeting defects compared to psidin55D4 single mutant ORNs, but the reduction in the number of Or59c ORNs seen in psidin55D4 single mutant ORNs is not rescued in the double mutants.

      (Stephan et al., 2012)

      Border follicle cells simultaneously homozygous for both Tm1ZCL0722 and psidin55D4 show less severe migration defects than single mutant border follicle cells.

      (Kim et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      psidinEQ

      (Sheng and Du, 2020)

      psidinCJ

      (Sheng and Du, 2020)

      psidinAB

      (Sheng and Du, 2020)

      psidinAE

      (Sheng and Du, 2020)

      psidine02846

      (Kim et al., 2011)
      Rescued by

      psidin85D1/psidin55D4 is rescued by psidinUAS.cKa/Scer\GAL4Act.PU

      (Kim et al., 2011)

      psidin55D4 is rescued by psidinUAS.cKa/Scer\GAL4slbo.2.6

      (Kim et al., 2011)
      Comments

      Expression of psidinScer\UAS.cKa under the control of Scer\GAL4slbo.2.6 rescues the migration defects seen in homozygous psidin55D4 border cells.

      Expression of psidinScer\UAS.cKa under the control of Scer\GAL4Act.PU rescues the lethality of psidin55D4/psidin85D1 animals.

      (Kim et al., 2011)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      psid-D4
      (Sheng and Du, 2020)
      psid55D4
      (Sheng and Du, 2020, Kim et al., 2011)
      psidin55D4
      (Stephan et al., 2012)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)