FlyBase Allele Report: Dmel\Gel[UAS.cDa]

General Information

Symbol

Dmel\Gel^UAS.cDa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of DuBoff

FlyBase ID

FBal0278277

Feature type

allele

Associated gene

Dmel\Gel

Associated Insertion(s)

Carried in Construct

P{UAS-Gel.D}

Also Known As

UAS-Gelsolin

Key Links

Transgenic product class

cDNA

(Duboff et al., 2012)

wild_type

(Duboff et al., 2012)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Duboff et al., 2012)

wild_type

(Duboff et al., 2012)

Mutagen

in vitro construct

(Duboff et al., 2012)

Progenitor genotype

Carried in construct

P{UAS-Gel.D}

Cytology

Description

UASt regulatory sequences drive expression of a Gel cDNA (SD07495).

(Duboff et al., 2012)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Gel

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates tauopathy

modeled by Hsap\MAPT^R406W.UAS

(Frost et al., 2016, Duboff et al., 2012)

ameliorates Parkinson's disease 1

modeled by Hsap\SNCA^QUAS.cOa

(Sarkar et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | adult stage, with Scer\GAL4^elav-C155

(Ordonez et al., 2018)

Phenotype Manifest In

adult brain, with Scer\GAL4^elav.PU

(Duboff et al., 2012)

mitochondrion, with Scer\GAL4^elav.PU

(Duboff et al., 2012)

mitochondrion | adult stage, with Scer\GAL4^elav-C155

(Ordonez et al., 2018)

Detailed Description

Statement

Reference

The expression of Gel^Scer\UAS.cDa under the control of Scer\GAL4^elav-C155 leads to a significant increase in the mitochondria size in the adult brain, as compared to controls.

(Ordonez et al., 2018)

Expression of Gel^Scer\UAS.cDa under the control of Scer\GAL4^Bx-MS1096 does not give rise to any wing defect.

(Ratnaparkhi, 2013)

The mitochondria in the neurons of adult brains expressing Gel^Scer\UAS.cDa under the control of Scer\GAL4^elav.PU are elongated compared to controls. Levels of neurotoxicity are similar to wild type.

(Duboff et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\GAL4^elav-C155/Gel^UAS.cDa is a suppressor of abnormal size | adult stage phenotype of Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb

(Ordonez et al., 2018)

NOT Suppressor of

Statement

Reference

Gel^UAS.cDa, Scer\GAL4^elav.PU is a non-suppressor of abnormal neuroanatomy phenotype of Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU

(Duboff et al., 2012)

Gel^UAS.cDa, Scer\GAL4^elav.PU is a non-suppressor of abnormal cell death phenotype of Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU

(Duboff et al., 2012)

Phenotype Manifest In

NOT suppressed by

Statement

Reference

Gel^UAS.cDa, Scer\GAL4^elav.PU has adult brain phenotype, non-suppressible by Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU

(Duboff et al., 2012)

Gel^UAS.cDa, Scer\GAL4^elav.PU has mitochondrion phenotype, non-suppressible by Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU

(Duboff et al., 2012)

Suppressor of

Statement

Reference

Scer\GAL4^elav-C155/Gel^UAS.cDa is a suppressor of mitochondrion | adult stage phenotype of Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb

(Ordonez et al., 2018)

Gel^UAS.cDa, Scer\GAL4^elav.PU is a suppressor of adult brain phenotype of Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU

(Duboff et al., 2012)

Gel^UAS.cDa, Scer\GAL4^elav.PU is a suppressor of mitochondrion phenotype of Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU

(Duboff et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of Gel^Scer\UAS.cDa enhances fog signalling, resulting in abnormal wing morphologies in both males and females expressing fog^Scer\UAS.cRa under the control of Scer\GAL4^Bx-MS1096.

(Ratnaparkhi, 2013)

Xenogenetic Interactions

Statement

Reference

The additional expression of Gel^Scer\UAS.cDa under the control of Scer\GAL4^elav-C155 partially suppresses the increased mitochondria size observed in the adult brain of individuals expressing Hsap\SNCA^{Ncra\QUAS.cOa} under the control of Ncra\QF^QF2.nSyb.

(Ordonez et al., 2018)

Expression of Gel^Scer\UAS.cDa significantly suppresses the increase in mitochondria length seen when Hsap\MAPT^{R406W.Scer\UAS} is expressed under the control of Scer\GAL4^elav.PU, with the rescue flies having a mitochondrial length similar to expression of Gel^Scer\UAS.cDa alone. The increases in neurotoxicity and superoxide production are also significantly rescued.

(Duboff et al., 2012)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Gel^Scer\UAS.cDa

Gel^UAS.cDa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of DuBoff

Secondary FlyBase IDs

References (6)

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