FlyBase Allele Report: Dmel\ap[f00451]

General Information

Symbol

Dmel\ap^f00451

Species

D. melanogaster

Name

FlyBase ID

FBal0280586

Feature type

allele

Associated gene

Dmel\ap

Associated Insertion(s)

PBac{WH}ap^f00451

Carried in Construct

Also Known As

PBac{WH}f00451

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Associated Insertion(s)

PBac{WH}ap^f00451

Cytology

Description

Allele components

Component

Use(s)

Inserted element

PBac{WH}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Also carries

FRT

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:5,737,383..5,737,383 [+]

(Bieli et al., 2015, Bieli et al., 2015, Gohl et al., 2008)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible

(Gohl et al., 2008)

visible (with ap^DG3)

(Bieli et al., 2015)

visible (with Df(2R)DG)

(Gohl et al., 2008)

visible (with Df(2R)DG-Mcp)

(Gohl et al., 2008)

visible (with Df(2R)nap1)

(Gohl et al., 2008)

Phenotype Manifest In

wing

(Gohl et al., 2008)

wing (with ap^DG3)

(Bieli et al., 2015)

wing (with Df(2R)DG)

(Gohl et al., 2008)

wing (with Df(2R)DG-Mcp)

(Gohl et al., 2008)

wing (with Df(2R)nap1)

(Gohl et al., 2008)

Detailed Description

Statement

Reference

Defects are seen at the dorsoventral boundary of ap^f00451/ap^DG3 mutant flies.

(Bieli et al., 2015)

Weak wing defects are seen in homozygous ap^f00451 flies and similar defects are seen in ap^f00451/Df(2R)nap1 transheterozygotes.

Very few wing defects are seen in ap^f00451/ap^UGO35 mutant flies.

Weak wing defects are seen in ap^f00451/Df(2R)DG-Mcp flies, similar to those seen in ap^f00451 homozygotes.

The wings of ap^{loxP.MCP-PRE.MM}/ap^f00451 transheterozygous flies appear completely wild type.

Wing defects are seen in Df(2R)DG/ap^f00451 mutant flies, but they are less severe than those seen in Df(2R)DG homozygotes.

(Gohl et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

ap^f00451 has visible phenotype, suppressible by su(Hw)⁷/su(Hw)^V

(Gohl et al., 2008)

ap^f00451 has visible phenotype, suppressible by mod(mdg4)^ul

(Gohl et al., 2008)

NOT Suppressor of

Statement

Reference

ap^f00451 is a non-suppressor of visible phenotype of mod(mdg4)^ul

(Gohl et al., 2008)

Phenotype Manifest In

Suppressed by

Statement

Reference

ap^f00451 has wing phenotype, suppressible by su(Hw)⁷/su(Hw)^V

(Gohl et al., 2008)

ap^f00451 has wing phenotype, suppressible by mod(mdg4)^ul

(Gohl et al., 2008)

NOT Suppressor of

Statement

Reference

ap^f00451 is a non-suppressor of wing vein L2 phenotype of mod(mdg4)^ul

(Gohl et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

A su(Hw)^V/su(Hw)⁷ background almost completely suppresses the wing defects seen in ap^f00451 mutant flies.

A homozygous mod(mdg4)^ul mutant background strongly suppresses the wing defects seen in ap^f00451 mutant flies. The wings of mod(mdg4)^ul ap^f00451 double mutants are almost wild type, with the exception of a disrupted L2 vein, although this defect is also seen in mod(mdg4)^ul mutant flies.

(Gohl et al., 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

ap^MM-Mcp

(Gohl et al., 2008)

ap^UGO35

(Gohl et al., 2008)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Mobilisation of the PBac{WH} element in ap^f00451 completely reverts the reduced viability and wing phenotypes.

(Gohl et al., 2008)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

ap^f00451

(Bieli et al., 2015, Gohl et al., 2008)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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