FlyBase Allele Report: Dmel\ap[DG3]

An approximately 44-kb deletion between two FRT sites located in PBac{WH}ap^f08090 and PBac{RB}e01573. A large part of the ap transcription unit is lost together with approximately 27-kb of intergenic DNA separating ap from l(2)09851. A considerable part of the ap open reading frame (ORF) located proximal to the break in ap^DG3 remains in place.

(Bieli et al., 2015)

Allele components

Component

Use(s)

Also carries

FRT

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

2R:5,709,923..5,754,029 [-]

Comment:

Scer\FRT-mediated recombination between the two progenitor insertions has deleted ~44.1 kb of sequence between them.

(Bieli et al., 2015)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | third instar larval stage (with ap^Xa)

(Bieli et al., 2015)

visible

(Bieli et al., 2015)

visible (with ap^11.1)

(Bieli et al., 2015)

visible (with ap^34.1)

(Bieli et al., 2015)

visible (with ap^attPΔEnh)

(Bieli et al., 2015)

visible (with ap^c1.2b)

(Bieli et al., 2015)

visible (with ap^c1.60c)

(Bieli et al., 2015)

visible (with ap^c1.78a)

(Bieli et al., 2015)

visible (with ap^c2.58c)

(Bieli et al., 2015)

visible (with ap^C2)

(Bieli et al., 2015)

visible (with ap^C5)

(Bieli et al., 2015)

visible (with ap^C52)

(Bieli et al., 2015)

visible (with ap^C1234)

(Bieli et al., 2015)

visible (with ap^C1345)

(Bieli et al., 2015)

visible (with ap^cDNA)

(Bieli et al., 2015)

visible (with ap^Dad52.4)

(Bieli et al., 2015)

visible (with ap^DG2)

(Bieli et al., 2015)

visible (with ap^DG6)

(Bieli et al., 2015)

visible (with ap^DG8)

(Bieli et al., 2015, Bieli et al., 2015)

visible (with ap^DG11)

(Bieli et al., 2015, Bieli et al., 2015)

visible (with ap^DG12)

(Bieli et al., 2015)

visible (with ap^DG14)

(Bieli et al., 2015)

visible (with ap^DG)

(Bieli et al., 2015, Bieli et al., 2015)

visible (with ap^empty)

(Bieli et al., 2015)

visible (with ap^f00451)

(Bieli et al., 2015)

visible (with ap^OR463C5B)

(Bieli et al., 2015)

visible (with ap^P)

(Bieli et al., 2015)

visible (with ap^R)

(Bieli et al., 2015)

visible (with ap^RXa)

(Bieli et al., 2015)

visible (with ap^RXaDad52.4)

(Bieli et al., 2015)

visible (with ap^t11b)

(Bieli et al., 2015)

visible (with ap^Xa)

(Bieli et al., 2015)

visible (with ap^Y)

(Bieli et al., 2015)

visible (with Df(2R)ap^12.1)

(Bieli et al., 2015)

visible (with Df(2R)ap^DG15)

(Bieli et al., 2015)

visible (with Df(2R)ap^DG16)

(Bieli et al., 2015)

visible (with Df(2R)BSC696)

(Bieli et al., 2015)

visible (with Df(2R)DG)

(Bieli et al., 2015)

Phenotype Manifest In

adult external thorax (with Df(2R)BSC696)

(Bieli et al., 2015)

adult thoracic sensillum (with Df(2R)BSC696)

(Bieli et al., 2015)

alar lobe (with ap^R)

(Bieli et al., 2015)

alar lobe (with ap^RXa)

(Bieli et al., 2015)

alar lobe (with ap^Y)

(Bieli et al., 2015)

haltere

(Bieli et al., 2015)

haltere (with ap^c1.2b)

(Bieli et al., 2015)

haltere (with ap^DG11)

(Bieli et al., 2015)

haltere (with ap^DG)

(Bieli et al., 2015)

haltere (with ap^P)

(Bieli et al., 2015)

haltere (with Df(2R)BSC696)

(Bieli et al., 2015)

wing (with ap^11.1)

(Bieli et al., 2015)

wing (with ap^34.1)

(Bieli et al., 2015)

wing (with ap^attPΔEnh)

(Bieli et al., 2015)

wing (with ap^c1.60c)

(Bieli et al., 2015)

wing (with ap^c1.78a)

(Bieli et al., 2015)

wing (with ap^c2.58c)

(Bieli et al., 2015)

wing (with ap^C2)

(Bieli et al., 2015)

wing (with ap^C5)

(Bieli et al., 2015)

wing (with ap^C52)

(Bieli et al., 2015)

wing (with ap^C1234)

(Bieli et al., 2015)

wing (with ap^C1345)

(Bieli et al., 2015)

wing (with ap^cDNA)

(Bieli et al., 2015)

wing (with ap^DG2)

(Bieli et al., 2015)

wing (with ap^DG6)

(Bieli et al., 2015)

wing (with ap^DG8)

(Bieli et al., 2015, Bieli et al., 2015)

wing (with ap^DG11)

(Bieli et al., 2015, Bieli et al., 2015)

wing (with ap^DG12)

(Bieli et al., 2015)

wing (with ap^DG14)

(Bieli et al., 2015)

wing (with ap^DG)

(Bieli et al., 2015, Bieli et al., 2015)

wing (with ap^empty)

(Bieli et al., 2015)

wing (with ap^f00451)

(Bieli et al., 2015)

wing (with ap^OR463C5B)

(Bieli et al., 2015)

wing (with ap^P)

(Bieli et al., 2015)

wing (with ap^t11b)

(Bieli et al., 2015)

wing (with ap^Xa)

(Bieli et al., 2015)

wing (with Df(2R)ap^12.1)

(Bieli et al., 2015)

wing (with Df(2R)ap^DG15)

(Bieli et al., 2015)

wing (with Df(2R)ap^DG16)

(Bieli et al., 2015)

wing (with Df(2R)BSC696)

(Bieli et al., 2015)

wing (with Df(2R)DG)

(Bieli et al., 2015)

wing blade (with ap^Dad52.4)

(Bieli et al., 2015)

wing blade (with ap^RXaDad52.4)

(Bieli et al., 2015)

wing hinge (with ap^R)

(Bieli et al., 2015)

wing hinge (with ap^RXa)

(Bieli et al., 2015)

wing hinge (with ap^Y)

(Bieli et al., 2015)

wing margin (with ap^C2)

(Bieli et al., 2015)

wing margin (with ap^Dad52.4)

(Bieli et al., 2015)

wing margin (with ap^R)

(Bieli et al., 2015)

wing margin (with ap^RXa)

(Bieli et al., 2015)

wing margin (with ap^RXaDad52.4)

(Bieli et al., 2015)

wing margin (with ap^Y)

(Bieli et al., 2015)

wing margin bristle (with ap^Xa)

(Bieli et al., 2015)

wing pouch | third instar larval stage (with ap^Xa)

(Bieli et al., 2015)

Detailed Description

Statement

Reference

ap^DG3/ap^MM flies have normal wings and halteres.

Homozygous ap^DG3 and ap^DG3/Df(2R)BSC696 flies display a complete loss of all wing and haltere structures. The bristle pattern is aberrant and the size of the dorsal thorax is reduced in ap^DG3/Df(2R)BSC696 mutants.

ap^DG/ap^DG3 flies lack all wing and haltere structures.

ap^DG11/ap^DG3 flies lack all wing and haltere structures.

The wing tissue of ap^Xa/ap^DG3 flies forms a short tube-like structure. Margin bristles are absent except for sometimes a few at the tip.

The dimension of the wing pouch in ap^Xa/ap^DG3 animals is reduced to about half the size of a wild-type pouch.

ap^RXaDad52.4/ap^DG3 flies have tube-like wing stumps which lack wing margin completely except for the occasional occurrence of a few margin hairs at the very tip.

ap^Dad52.4/ap^DG3 flies have tube-like wing stumps which lack wing margin completely except for the occasional occurrence of a few margin hairs at the very tip.

ap^P/ap^DG3 flies do not develop any wing or haltere tissue.

Most of the wing margin, the alula and the hinge region are poorly formed in ap^Y/ap^DG3 mutants.

Most of the wing margin, the alula and the hinge region are poorly formed in ap^R/ap^DG3 mutants.

Most of the wing margin, the alula and the hinge region are poorly formed in ap^RXa/ap^DG3 mutants.

(Bieli et al., 2015)

No wing phenotypes are seen in ap^DG3 heterozygotes.

No wings are seen in ap^DG2/ap^DG3 mutant flies.

No wings are seen in Df(2R)ap^DG16/ap^DG3 mutant flies.

No wings are seen in Df(2R)ap^12.1/ap^DG3 mutant flies.

No wings are seen in Df(2R)ap^DG15/ap^DG3 mutant flies.

Defects are seen at the dorsoventral boundary of ap^f00451/ap^DG3 mutant flies.

No wings are seen in ap^DG8/ap^DG3 mutant flies.

No wings are seen in ap^DG11/ap^DG3 mutant flies.

No wings are seen in ap^t11b/ap^DG3 mutant flies.

In ap^c2.73c/ap^DG3 mutant flies only small wing and haltere stumps form.

In ap^c1.2b/ap^DG3 mutant flies only small wing and haltere stumps form.

The wings of ap^c1.60c/ap^DG3 mutant flies exhibit notches along the wing margin.

No wings are seen in ap^DG6/ap^DG3 mutant flies.

No wings are seen in ap^DG12/ap^DG3 mutant flies.

ap^DG14/ap^DG3 mutant flies form wing stumps of almost normal length but wing margin formation is severely impaired.

ap^11.1/ap^DG3 mutant flies have notched wings.

ap^34.1/ap^DG3 mutant flies have notched wings.

No wing tissue is formed in ap^attPΔEnh/ap^DG3 flies.

No wing defects are seen in ap^C12345/ap^DG3 mutant flies.

No wing defects are seen in ap^C2345/ap^DG3 flies.

No wing defects are seen in ap^C235/ap^DG3 flies.

No wing defects are seen in ap^C25/ap^DG3 flies.

Wing defects are seen in ap^C25/ap^DG3 flies. Long wing stumps with defective wing margin and hinge are formed.

No wing tissue is formed in ap^C5/ap^DG3 flies.

Wing defects are seen in ap^C1234/ap^DG3 flies. Long wing stumps with defective wing margin and hinge are formed.

No wing tissue is formed in ap^C1345/ap^DG3 flies.

No wing defects are seen in ap^C52/ap^DG3 flies.

No wing defects are seen in ap^C15342/ap^DG3 flies.

Wing defects are seen in ap^OR463C5B/ap^DG3 flies. Wing size is reduced, but all margin structures are formed.

Wing defects are seen in ap^cDNA/ap^DG3 flies.

No wing defects are seen in ap^cDNAint2.3/ap^DG3 flies.

No wing defects are seen in ap^{KI.T:Avic\GFP}/ap^DG3 mutant flies.

No wing defects are seen in ap^72.2/ap^DG3 mutant flies.

No wing defects are seen in ap^62.3/ap^DG3 mutant flies.

No wings are seen in ap^c1.78a/ap^DG3 mutant flies.

No wings are seen in ap^c2.58c/ap^DG3 mutant flies.

No wing tissue is formed in ap^DG/ap^DG3 mutant flies.

(Bieli et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

No wing phenotypes are seen in l(2)09851^EY06365/ap^DG3 mutant flies.

(Bieli et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Df(2R)ap^DG3

(Bieli et al., 2015, Bieli et al., 2015)

ap^DG3

(Bieli et al., 2015)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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