FlyBase Allele Report: Dmel\ap[MM-Mcp]

General Information

Symbol

Dmel\ap^MM-Mcp

Species

D. melanogaster

Name

FlyBase ID

FBal0280589

Feature type

allele

Associated gene

Dmel\ap

Associated Insertion(s)

P{(loxP.MCP-PRE)(-FRT)Flipper2}ap^MM-Mcp

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

FLPase

Nature of the Allele

Allele class

Mutagen

FLPase

(Gohl et al., 2008)

Progenitor genotype

P{(loxP.MCP-PRE)(FRT.bxd-PRE)Flipper2}ap^MM-MCP-bxd

(Gohl et al., 2008)

Associated Insertion(s)

P{(loxP.MCP-PRE)(-FRT)Flipper2}ap^MM-Mcp

Cytology

Description

The FRT cassette has been excised from the P{(loxP.MCP-PRE)(FRT.bxd-PRE)Flipper2} element in the P{(loxP.MCP-PRE)(FRT.bxd-PRE)Flipper2}ap^MM-Mcp-bxd insertion.

(Gohl et al., 2008)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:5,727,233..5,727,233

(Bieli et al., 2015, Gohl et al., 2008)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

short lived

(Gohl et al., 2008)

visible

(Gohl et al., 2008)

visible (with ap⁴)

(Gohl et al., 2008)

visible (with ap^56f)

(Gohl et al., 2008)

visible (with ap^f08090)

(Gohl et al., 2008)

visible (with ap^rK568)

(Gohl et al., 2008)

visible (with ap^UGO35)

(Gohl et al., 2008)

visible (with Df(2R)DG)

(Gohl et al., 2008)

visible (with Df(2R)DG-Mcp)

(Gohl et al., 2008)

visible (with Df(2R)nap1)

(Gohl et al., 2008)

Phenotype Manifest In

haltere

(Gohl et al., 2008)

wing

(Gohl et al., 2008)

wing (with ap⁴)

(Gohl et al., 2008)

wing (with ap^56f)

(Gohl et al., 2008)

wing (with ap^f08090)

(Gohl et al., 2008)

wing (with ap^rK568)

(Gohl et al., 2008)

wing (with ap^UGO35)

(Gohl et al., 2008)

wing (with Df(2R)DG)

(Gohl et al., 2008)

wing (with Df(2R)DG-Mcp)

(Gohl et al., 2008)

wing (with Df(2R)nap1)

(Gohl et al., 2008)

wing disc

(Gohl et al., 2008)

Detailed Description

Statement

Reference

Wing defects are seen in homozygous ap^{loxP.MCP-PRE.MM} mutant flies, ranging from complete lack of wings, to wings that are severely blistered or crumpled. The halteres are also frequently missing. An identical wing phenotype is seen in hemizygous ap^{loxP.MCP-PRE.MM} flies. The wing discs are reduced in size and deformed. Similar wing defects are seen in ap^{loxP.MCP-PRE.MM}/Df(2R)nap1 flies.

Homozygous ap^{loxP.MCP-PRE.MM} mutant flies are short lived and cannot be maintained as a homozygous stock.

Wing defects are seen in ap^{loxP.MCP-PRE.MM}/ap^UGO35 mutant flies, but they are significantly less severe than those seen in ap^{loxP.MCP-PRE.MM} homozygotes.

Wing defects are seen in ap^{loxP.MCP-PRE.MM}/ap^f08090 mutant flies, but they are significantly less severe than those seen in ap^{loxP.MCP-PRE.MM} homozygotes.

Wing defects are seen in ap^{loxP.MCP-PRE.MM}/ap^rK568 mutant flies, but they are significantly less severe than those seen in ap^{loxP.MCP-PRE.MM} homozygotes.

Wing defects are seen in ap^{loxP.MCP-PRE.MM}/ap⁴ mutant flies, but they are significantly less severe than those seen in ap^{loxP.MCP-PRE.MM} homozygotes.

Wing defects are seen in ap^{loxP.MCP-PRE.MM}/ap^56f mutant flies, but they are significantly less severe than those seen in ap^{loxP.MCP-PRE.MM} homozygotes.

The wings of ap^{loxP.MCP-PRE.MM}/ap^f00451 transheterozygous flies appear completely wild type.

Wing defects are seen in ap^{loxP.MCP-PRE.MM}/Df(2R)DG-Mcp flies, similar to those seen in ap^{loxP.MCP-PRE.MM} homozygotes.

Wing defects are seen in ap^{loxP.MCP-PRE.MM}/Df(2R)DG mutant flies, but they are less severe than those seen in ap^{loxP.MCP-PRE.MM} homozygotes.

(Gohl et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

ap^MM-Mcp has visible phenotype, non-suppressible by su(Hw)⁷/su(Hw)^V

(Gohl et al., 2008)

ap^MM-Mcp has visible phenotype, non-suppressible by mod(mdg4)^ul

(Gohl et al., 2008)

Phenotype Manifest In

NOT suppressed by

Statement

Reference

ap^MM-Mcp has wing phenotype, non-suppressible by su(Hw)⁷/su(Hw)^V

(Gohl et al., 2008)

ap^MM-Mcp has wing phenotype, non-suppressible by mod(mdg4)^ul

(Gohl et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

A su(Hw)^V/su(Hw)⁷ mutant background has no effect on the wing defects seen in ap^{loxP.MCP-PRE.MM} mutant flies.

A homozygous mod(mdg4)^ul mutant background has no effect on the wing defects seen in ap^{loxP.MCP-PRE.MM} mutant flies.

(Gohl et al., 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

ap^f00451

(Gohl et al., 2008)

Partially complements

ap^f08090

(Gohl et al., 2008)

ap^56f

(Gohl et al., 2008)

ap⁴

(Gohl et al., 2008)

ap^rK568

(Gohl et al., 2008)

ap^UGO35

(Gohl et al., 2008)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

ap^MM-Mcp

(Gohl et al., 2008)

ap^{P1\loxP.MCP-PRE.MM}

ap^{loxP.MCP-PRE.MM}

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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