FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\MYChs.1
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General Information
Symbol
Hsap\MYChs.1
Species
H. sapiens
Name
FlyBase ID
FBal0281054
Feature type
allele
Associated gene
Hsap\MYC
Associated Insertion(s)
Carried in Construct
P{hs-hMYC.1}
Key Links
Transgenic product class
wild_type
(Benassayag et al., 2005)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Benassayag et al., 2005)
Mutagen
in vitro construct
(Benassayag et al., 2005)
Progenitor genotype
Carried in construct
P{hs-hMYC.1}
Cytology
Description

An Hsp70 promoter drives expression of Hsap\MYC isoform 1. The non-canonical CTG translation initiation codon of isoform 1 has been mutated to ATG. The alternative downstream ATG site has been mutated to ATC to prevent production of isoform 2 (which is usually produced using this translation start site) in this construct.

(Benassayag et al., 2005)
Allele components
Component
Use(s)
Regulatory region(s)
Hsp70
Encoded product / tool
Hsap\MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Hsap\MYChs.1 is a suppressor | partially of lethal phenotype of MycPG45

      (Benassayag et al., 2005)

      Hsap\MYChs.1 is a suppressor of lethal phenotype of MycPL35

      (Benassayag et al., 2005)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of Hsap\MYChs.1 retards the lethal phase of dmPG45 males.

      Expression of Hsap\MYChs.1 allows a few adult dmPL35 males to survive.

      (Benassayag et al., 2005)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Hsap\MYChs.1
      Name Synonyms
      Secondary FlyBase IDs
        References (1)