FB2026_02 , released June 18, 2026
Allele: Dmel\LrrkUAS.cDa
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General Information
Symbol
Dmel\LrrkUAS.cDa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Dodson
FlyBase ID
FBal0282479
Feature type
allele
Associated gene
Dmel\Lrrk
Associated Insertion(s)
Carried in Construct
P{UAS-Lrrk.D}
Also Known As
lrrkWT, UAS-lrrk
Key Links
Transgenic product class
genomic_DNA
(Dodson et al., 2012)
wild_type
(Dodson et al., 2012)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Dodson et al., 2012)
wild_type
(Dodson et al., 2012)
Mutagen
in vitro construct
(Dodson et al., 2012)
Progenitor genotype
Carried in construct
P{UAS-Lrrk.D}
Cytology
Description

UASt regulatory sequences drive expression of an NheI-KpnI fragment of Lrrk genomic DNA (from BACR26M03).

(Dodson et al., 2012)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Lrrk
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of LrrkScer\UAS.cDa under the control of Scer\GAL4CY2 does not result in perinuclear lysosome clustering.

      (Dodson et al., 2014)

      Expression of LrrkScer\UAS.cDa under the control of Scer\GAL4CY2 has no effect on lysosome distribution in the follicle cells.

      (Dodson et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      LrrkUAS.cDa, Scer\GAL4CY2 is a suppressor of lysosome phenotype of Rab7Q67L.UASp.YFP, Scer\GAL4CY2

      (Dodson et al., 2012)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The increased clustering of lysosomes which is seen in the follicle cells of females expressing Rab7Q67L.Scer\UAS.P\T.T:Avic\GFP-YFP under the control of Scer\GAL4CY2 is suppressed by co-expression of LrrkScer\UAS.cDa.

      (Dodson et al., 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4CY2/LrrkUAS.cDa rescues Lrrk2/Lrrk1

      (Dodson et al., 2014)

      Scer\GAL4CY2/LrrkUAS.cDa rescues Df(3R)BSC141/Lrrke03680

      (Dodson et al., 2012)
      Partially rescues

      Scer\GAL4CY2/LrrkUAS.cDa partially rescues Lrrkunspecified

      (Dodson et al., 2014)

      Scer\GAL4RapGAP1-OK6/LrrkUAS.cDa partially rescues Lrrkunspecified

      (Dodson et al., 2014)
      Comments

      Expression of LrrkScer\UAS.cDa under the control of Scer\GAL4CY2 rescues the semi-sterility phenotype of Lrrk1/Lrrk2 mutants.

      Expression of LrrkScer\UAS.cDa under the control of Scer\GAL4CY2 partially rescues the premature follicle cell death phenotype and enlarged-lysosome phenotype of Lrrk mutants.

      Expression of LrrkScer\UAS.cDa under the control of Scer\GAL4RapGAP1-OK6 partially rescues the neuromuscular junction synapse overgrowth phenotype of Lrrk mutants.

      (Dodson et al., 2014)

      Expression of LrrkScer\UAS.cDa under the control of Scer\GAL4CY2 fully rescues the reduced fertility of Lrrke03680/Df(3R)BSC141 females.

      (Dodson et al., 2012)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      LrrkScer\UAS.cDa
      LrrkUAS.cDa
      lrrkWT
      (Dodson et al., 2014, Dodson et al., 2012)
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Dodson
      Secondary FlyBase IDs
        References (2)