Cog7z-4495/Cog7z-5797 transheterozygotes exhibit pronounced locomotor defects: larvae show irregular crawling with more turns and shorter distances, decreased frequency of peristaltic contractions and decreased distance per contraction, as compared to controls; adults show decreased climbing ability, as compared to controls. These individuals also show a held-out wing phenotype and present heat sensitive paralysis (38[o]C). About half spermatids in testes are multinucleate, indicating cytokinesis failure.
Cog7z-4495/Cog7z-5797 transheterozygous larvae show exhibit neuromuscular junctions with significantly fewer boutons, but similar primary branch number, as compared to controls.
The majority of spermatids are multinucleate, suggesting a failure of meiotic cytokinesis, in Cog7z-4495/Cog7z-5797 males.