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General Information
Symbol
Dmel\sauZ2217
Species
D. melanogaster
Name
FlyBase ID
FBal0178119
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

G2230058A

Amino acid change:

E273K | sau-PA; E273K | sau-PD; E273K | sau-PE

Reported amino acid change:

E273K

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: E273K.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

sauZ2217 homozygous adults present heat sensitive paralysis (38[o]C), unlike heterozygotes and wild-type controls. These mutants exhibit normal wing posture.

Most spermatids in sauZ2217/Df(2L)Exel7010 males testes are multinucleate, indicating cytokinesis failure.

sauZ2217/Df(2L)Exel7010 transheterozygotes are short lived compared to controls.

The majority of sauZ2217 mutant spermatids have one large nebenkern with four nuclei of normal size, indicating a cytokinetic failure in both meiotic divisions. A very small proportion (<1%) have two nuclei and a large nebenkern, indicating failure of only one of the meiotic divisions. An equally small proportion have three nuclei, indicating failure of cytokinesis in the first meiotic division, followed by budding off of only one daughter cell in the second meiotic division. A proportion of spermatids (<3%) have over four nuclei, which may result from defects in the mitotic divisions preceding mitosis. Spermatocytes of sauZ2217 mutants lack an organized central spindle and an F-actin ring throughout ana-telophase. The equatorial anillin band is present but fails to constrict properly.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
Statement
Reference
Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

sauZ2217/sauZ2217, Cog7z-4495/+ and sauZ2217/sauZ2217, Cog7z-5797/+ adults exhibit held-out wings; sauZ2217/sauZ2217, Cog7z-4495/+ wings also appear swollen and crumpled.

sauZ2217/+ ; fwd3/Df(3L)7C, sauZ2217/sauZ2217 ; fwd3/+ and sauZ2217/Df(2L)Exel6007 ; fwd3/+ animals are viable, but sauZ2217/Df(2L)Exel6007 ; fwd3/Df(3L)7C and sauZ2217/sauZ2217 ; fwd3/Df(3L)7C double mutants die during larval stages.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (5)