FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\sau
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General Information
Symbol
Dmel\sau
Species
D. melanogaster
Name
sauron
Annotation Symbol
CG7085
Feature Type
protein_coding_gene
FlyBase ID
FBgn0267378
Gene Model Status
Current
Stock Availability
10 publicly available
Gene Summary
Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi (PubMed:19837035, PubMed:24786584). Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (By similarity). May also bind to the coatomer to regulate Golgi membrane trafficking (PubMed:23720043, PubMed:24786584). May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion (By similarity). Also involved in the control of the localization of Golgi enzymes through interaction with their cytoplasmic part (By similarity). Functions in cytokinesis by regulating contractile ring formation and vesicle trafficking during cleavage furrow ingression (PubMed:24786584). May also have a role in the intital steps of central spindle formation (PubMed:24786584). Can also bind phosphatidylinositol-3-phosphate and phosphatidylinositol-5-phosphate in vitro (PubMed:24786584). (UniProt, Q9VQ93)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

GOLPH3, dGOLPH3, l(2)s5379, rti, rotini

Key Links
Genomic Location
Cytogenetic map
22D4-22D4
Sequence location
Recombination map
2-5
RefSeq locus
NT_033779 REGION:2226342..2231099
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (28 terms)
Molecular Function (6 terms)
Terms Based on Experimental Evidence (6 terms)
CV Term
Evidence
References
enables cargo adaptor activity
inferred from direct assay
(Welch et al., 2024)
enables phosphatidic acid binding
inferred from direct assay
(Sechi et al., 2014)
enables phosphatidylinositol-3-phosphate binding
inferred from direct assay
(Sechi et al., 2014)
enables phosphatidylinositol-4-phosphate binding
inferred from direct assay
(Sechi et al., 2014)
inferred from direct assay
(Dippold et al., 2009)
enables phosphatidylinositol-5-phosphate binding
inferred from direct assay
(Sechi et al., 2014)
enables small GTPase binding
inferred from physical interaction with FLYBASE:Rab5; FB:FBgn0014010
(Sechi et al., 2014)
inferred from physical interaction with FLYBASE:Rab11; FB:FBgn0015790
(Sechi et al., 2014)
inferred from physical interaction with UniProtKB:O18332
(Sechi et al., 2017)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables cargo adaptor activity
inferred from sequence or structural similarity with UniProtKB:Q9H4A5
(Gene Ontology Curators, 2002-)
enables phosphatidylinositol-4-phosphate binding
inferred from electronic annotation with InterPro:IPR008628
(InterPro Project Members, 2004-)
inferred from biological aspect of ancestor with PANTHER:PTN000294961
(GO Reference Genome Project, 2011-)
Biological Process (16 terms)
Terms Based on Experimental Evidence (12 terms)
CV Term
Evidence
References
involved_in actomyosin contractile ring assembly
inferred from mutant phenotype
(Sechi et al., 2014, Giansanti et al., 2004)
involved_in cleavage furrow formation
inferred from mutant phenotype
(Sechi et al., 2014)
involved_in Golgi organization
inferred from mutant phenotype
(Sechi et al., 2014)
involved_in male meiosis cytokinesis
inferred from mutant phenotype
(Sechi et al., 2014)
involved_in meiosis I cytokinesis
inferred from mutant phenotype
(Giansanti et al., 2004)
involved_in meiosis II cytokinesis
inferred from mutant phenotype
(Giansanti et al., 2004)
involved_in mitotic cytokinesis
inferred from mutant phenotype
(Sechi et al., 2014)
involved_in mitotic spindle assembly
inferred from mutant phenotype
(Sechi et al., 2014)
involved_in retrograde transport, vesicle recycling within Golgi
inferred from mutant phenotype
(Chang et al., 2013)
involved_in spindle assembly involved in male meiosis
inferred from mutant phenotype
(Sechi et al., 2014)
involved_in spindle assembly
inferred from mutant phenotype
(Giansanti et al., 2004)
involved_in symbiont entry into host cell
inferred from high throughput mutant phenotype
(Hodgson et al., 2019)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
involved_in Golgi organization
inferred from biological aspect of ancestor with PANTHER:PTN000294961
(GO Reference Genome Project, 2011-)
involved_in Golgi to plasma membrane protein transport
inferred from biological aspect of ancestor with PANTHER:PTN000294961
(GO Reference Genome Project, 2011-)
involved_in Golgi vesicle budding
inferred from biological aspect of ancestor with PANTHER:PTN000294961
(GO Reference Genome Project, 2011-)
involved_in protein targeting to Golgi apparatus
inferred from sequence or structural similarity with UniProtKB:Q9H4A6
(Gene Ontology Curators, 2002-)
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
inferred from biological aspect of ancestor with PANTHER:PTN000294961
(GO Reference Genome Project, 2011-)
Cellular Component (6 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
located_in cleavage furrow
inferred from direct assay
(Sechi et al., 2020, Sechi et al., 2014)
located_in Golgi apparatus
inferred from direct assay
(Sechi et al., 2017, Sechi et al., 2014, Chang et al., 2013)
located_in Golgi membrane
inferred from direct assay
(Frappaolo et al., 2017)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
is_active_in cytosol
inferred from biological aspect of ancestor with PANTHER:PTN000294961
(GO Reference Genome Project, 2011-)
is_active_in Golgi cisterna
inferred from biological aspect of ancestor with PANTHER:PTN000294961
(GO Reference Genome Project, 2011-)
located_in Golgi cisterna
inferred from sequence or structural similarity with UniProtKB:Q9H4A6
(Gene Ontology Curators, 2002-)
is_active_in trans-Golgi network
inferred from biological aspect of ancestor with PANTHER:PTN000294961
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the GOLPH3/VPS74 family. (Q9VQ93)
Protein Signatures (InterPro)
Summaries
Protein Function (UniProtKB)
Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi (PubMed:19837035, PubMed:24786584). Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (By similarity). May also bind to the coatomer to regulate Golgi membrane trafficking (PubMed:23720043, PubMed:24786584). May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion (By similarity). Also involved in the control of the localization of Golgi enzymes through interaction with their cytoplasmic part (By similarity). Functions in cytokinesis by regulating contractile ring formation and vesicle trafficking during cleavage furrow ingression (PubMed:24786584). May also have a role in the intital steps of central spindle formation (PubMed:24786584). Can also bind phosphatidylinositol-3-phosphate and phosphatidylinositol-5-phosphate in vitro (PubMed:24786584).
(UniProt, Q9VQ93)
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\sau for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VQ93)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.47

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.44

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
sau-RA
FBtr0077840
NM_134814
2395
294
sau-RD
FBtr0100673
NM_001014460
2585
294
sau-RE
FBtr0100674
NM_001032049
1720
294
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
sau-PA
FBpp0100138
33.5
294
5.05
Q9VQ93
NP_608658
AAF51284
sau-PD
FBpp0100140
33.5
294
5.05
Q9VQ93
NP_001014460
AAX53593
sau-PE
FBpp0100141
33.5
294
5.05
Q9VQ93
NP_001027220
AAN10452
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

294 aa isoforms: sau-PA, sau-PD, sau-PE
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Homooligomer (By similarity). Interacts with botv, Ext2 and ttv (PubMed:23720043). Interacts with Vti1 (PubMed:23720043). Interacts with Vps35, Rab5, Chc, Rab11, zip, Pav and Septin1 (PubMed:24786584).

(UniProt, Q9VQ93)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\sau using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.17

Transcript Expression
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage | male & spermatogenesis
spermatocyte
(Sechi et al., 2014)
primary spermatocyte in meiotic telophase I
(Sechi et al., 2014)
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage | male
testis
(Sechi et al., 2014)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cleavage furrow
inferred from direct assay
(Sechi et al., 2020, Sechi et al., 2014)
located_in Golgi apparatus
inferred from direct assay
(Sechi et al., 2017, Sechi et al., 2014, Chang et al., 2013)
located_in Golgi membrane
inferred from direct assay
(Frappaolo et al., 2017)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\sau in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 5 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of sau
Transgenic constructs containing regulatory region of sau
Aberrations (Deficiencies and Duplications) ( 6 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal (with Df(2L)BSC688)
lethal | recessive
lethal - all die before end of pupal stage, with Scer\GAL4pnr-MD237
lethal - all die during larval stage (with Df(2L)Exel7010)
lethal - all die during larval stage | recessive
partially lethal - majority die
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
male sterile (with Df(2L)Exel6007)
male sterile (with Df(2L)Exel7010)
male sterile (with saus5379)
male sterile (with sauZ2217)
Other Phenotypes
Allele
abnormal cytokinesis | male | recessive
abnormal meiotic cell cycle | male (with Df(2L)Exel6007)
abnormal meiotic cell cycle | male (with Df(2L)Exel7010)
abnormal meiotic cell cycle | male (with saus5379)
abnormal meiotic cell cycle | male (with sauZ2217)
abnormal meiotic cell cycle | male | recessive
abnormal mitotic cell cycle, with Scer\GAL4αTub84B.PL
abnormal mitotic cell cycle | male | recessive
paralytic | adult stage | dominant | heat sensitive
segment polarity phenotype | germline clone
short lived (with Df(2L)Exel7010)
some die during pupal stage, with Scer\GAL4pnr-MD237
Phenotype manifest in
Allele
actomyosin contractile ring, with Scer\GAL4αTub84B.PL
actomyosin contractile ring (with Df(2L)Exel7010)
contractile ring & meiotic cell cycle | male
Golgi apparatus (with Df(2L)Exel7010)
microtubule (with Df(2L)Exel7010)
Nebenkern
nucleus | spermatogenesis (with Df(2L)Exel7010)
onion stage spermatid, with Scer\GAL4VP16.bam
onion stage spermatid (with Df(2L)Exel7010)
onion stage spermatid (with saus5379)
onion stage spermatid (with sauZ2217)
primary spermatocyte (with Df(2L)Exel7010)
spermatid (with Df(2L)Exel7010)
spermatid & nucleus | supernumerary
spindle, with Scer\GAL4αTub84B.PL
spindle (with Df(2L)Exel7010)
spindle & meiotic cell cycle | male
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (2)
Hsap\GOLPH3
14 of 14
Yes
Yes
2  
Hsap\GOLPH3L
9 of 14
No
Yes
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (2)
Rnor\Golph3
14 of 14
Yes
Yes
Rnor\Golph3l
9 of 14
No
Yes
Mus musculus (laboratory mouse) (2)
Mmus\Golph3
14 of 14
Yes
Yes
Mmus\Golph3l
8 of 14
No
Yes
Xenopus tropicalis (Western clawed frog) (2)
Xtro\golph3
11 of 13
Yes
Yes
Xtro\golph3l
6 of 13
No
Yes
Danio rerio (Zebrafish) (3)
Drer\golph3b
14 of 14
Yes
Yes
Drer\golph3a
13 of 14
No
Yes
Drer\golph3l
8 of 14
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\Y47G6A.18
14 of 14
Yes
Yes
Anopheles gambiae (African malaria mosquito) (2)
Agam\AgaP_AGAP012606
12 of 12
Yes
Yes
Agam\AgaP_AGAP012632
11 of 12
No
Yes
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\VPS74
11 of 13
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\SPAC5D6.13
10 of 12
Yes
Yes
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:sau. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    GOLPH3; golgi phosphoprotein 3
    14 of 14
    612207
         
        GOLPH3L; golgi phosphoprotein 3 like
        9 of 14
        612208
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            Interaction Browsers
            View in FlyBase Interactions Browser   View in MIST tool (external link)
            Please see the Physical Interaction reports below for full details
            protein-protein
            Physical Interaction
            Assay
            References
            sau - 14-3-3ζ
            two hybrid, pull down, western blot, anti tag western blot
            (Frappaolo et al., 2022)
            sau - Atx2
            pull down, Identification by mass spectrometry, anti tag western blot, anti bait coimmunoprecipitation
            (Sechi et al., 2021)
            sau - Chc
            anti tag coimmunoprecipitation, western blot
            (Sechi et al., 2014)
            sau - Clc
            pull down, anti tag western blot
            (Sechi et al., 2014)
            sau - Cog6
            two hybrid
            (Frappaolo et al., 2017)
            sau - Cog7
            pull down, western blot, proximity ligation assay, fluorescence microscopy, anti tag coimmunoprecipitation, two hybrid, Identification by mass spectrometry
            (Sechi et al., 2021, Frappaolo et al., 2017)
            sau - Fmr1
            anti bait coimmunoprecipitation, western blot, pull down, Identification by mass spectrometry
            (Sechi et al., 2021)
            sau - Lst8
            pull down, anti tag western blot, two hybrid
            (Frappaolo et al., 2022)
            sau - Pacs
            anti tag coimmunoprecipitation, western blot
            (Frappaolo et al., 2025)
            sau - Rab1
            pull down, anti tag western blot, two hybrid, anti bait coimmunoprecipitation, western blot, proximity ligation assay, fluorescence microscopy
            (Frappaolo et al., 2017, Sechi et al., 2017)
            sau - Rab10
            pull down, Identification by mass spectrometry, anti tag coimmunoprecipitation, western blot
            (Sechi et al., 2021)
            sau - Rab11
            pull down, anti tag western blot, anti tag coimmunoprecipitation, western blot, surface plasmon resonance, predetermined participant
            (Sechi et al., 2017, Sechi et al., 2014)
            sau - Rab5
            anti tag coimmunoprecipitation, western blot
            (Sechi et al., 2014)
            sau - Rab8
            anti tag coimmunoprecipitation, western blot, pull down, Identification by mass spectrometry
            (Sechi et al., 2021)
            sau - Rac2
            pull down, Identification by mass spectrometry, anti tag coimmunoprecipitation, western blot
            (Sechi et al., 2021)
            sau - Rheb
            anti tag coimmunoprecipitation, western blot
            (Frappaolo et al., 2022)
            sau - SH3PX1
            pull down, western blot, Identification by mass spectrometry
            (Sechi et al., 2021)
            sau - Sec22
            pull down, Identification by mass spectrometry, anti tag coimmunoprecipitation, western blot
            (Sechi et al., 2021)
            sau - Sec31
            pull down, Identification by mass spectrometry, western blot
            (Sechi et al., 2021)
            sau - Septin1
            pull down, western blot, anti bait coimmunoprecipitation
            (Sechi et al., 2014)
            sau - Septin2
            anti bait coimmunoprecipitation, western blot
            (Sechi et al., 2014)
            sau - Tctp
            anti tag coimmunoprecipitation, western blot, two hybrid, pull down, anti tag western blot
            (Frappaolo et al., 2022)
            sau - Vps35
            pull down, anti tag western blot, anti tag coimmunoprecipitation
            (Sechi et al., 2014)
            sau - Vti1a
            pull down, western blot, two hybrid
            (Chang et al., 2013)
            sau - botv
            anti tag coimmunoprecipitation, western blot
            (Chang et al., 2013)
            sau - fws
            two hybrid, pull down, western blot
            (Frappaolo et al., 2017)
            sau - pav
            pull down, western blot, anti tag coimmunoprecipitation, molecular weight estimation by staining, two hybrid
            (Sechi et al., 2020, Sechi et al., 2014)
            sau - shi
            pull down, Identification by mass spectrometry, western blot
            (Sechi et al., 2021)
            sau - sotv
            anti tag coimmunoprecipitation, anti tag western blot
            (Chang et al., 2013)
            sau - sqh
            pull down, western blot, anti tag coimmunoprecipitation
            (Sechi et al., 2020)
            sau - ttv
            anti tag coimmunoprecipitation, western blot
            (Chang et al., 2013)
            sau - zip
            pull down, western blot, anti tag coimmunoprecipitation, anti tag western blot
            (Sechi et al., 2014)
            sau - αCOP
            pull down, Identification by mass spectrometry, anti bait coimmunoprecipitation, western blot
            (Sechi et al., 2021, Frappaolo et al., 2017)
            sau - βCOP
            anti tag coimmunoprecipitation, western blot, pull down, Identification by mass spectrometry
            (Sechi et al., 2021)
            sau - δCOP
            pull down, anti tag western blot, Identification by mass spectrometry
            (Sechi et al., 2021)
            Summary of Genetic Interactions
            Interaction Browsers
            View in FlyBase Interactions Browser   View in MIST tool (external link)
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            sau
            enhanceable
            Cog7
            (Frappaolo et al., 2017)
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Cog7
            enhanceable
            sau
            (Frappaolo et al., 2017)
            External Data
            Subunit Structure (UniProtKB)
            Homooligomer (By similarity). Interacts with botv, Ext2 and ttv (PubMed:23720043). Interacts with Vti1 (PubMed:23720043). Interacts with Vps35, Rab5, Chc, Rab11, zip, Pav and Septin1 (PubMed:24786584).
            (UniProt, Q9VQ93 )
            Linkouts
            DroID - A comprehensive database of gene and protein interactions.
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Signaling Pathways (FlyBase)
            Metabolic Pathways
            FlyBase
            External Links
            External Data
            Linkouts
            Class of Gene
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            2L
            Recombination map
            2-5
            Cytogenetic map
            22D4-22D4
            Sequence location
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            22D4-22D4
            Limits computationally determined from genome sequence between P{lacW}s4989 and P{lacW}Rab5k08232
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            22D3-22D4
            (determined by in situ hybridisation)
            (Spradling et al., 1999)
            22D3-22D4
            22D4--5
            (BDGP Project Members, 1994-1999)
            Experimentally Determined Recombination Data
            Location

            2-5

            (FlyBase, 2016)

            2-4.5

            (Comeron et al., 2012)

            2-7.1

            (Giansanti et al., 2004)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (10)
            Genomic Clones (13)
             

            Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

            cDNA Clones (34)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequenced
            BDGP DGC clones
            Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
              Other clones
              RNAi and Array Information
              Linkouts
              Antibody Information
              Laboratory Generated Antibodies
               

              polyclonal

              (Sechi et al., 2014, Chang et al., 2013)
              Commercially Available Antibodies
               
              Cell Line Information
              Publicly Available Cell Lines
               
                Other Stable Cell Lines
                 
                  Other Comments

                  Area matching Drosophila ESTs AA949990 and AA246423.

                  (Davies, 2001.3.15)
                  Relationship to Other Genes
                  Source for database merge of

                  Source for merge of: l(2)s5379 BcDNA:LD10657

                  (FlyBase, 1996-)

                  Source for merge of: l(2)s5379 BEST:LD28579

                  (Rana, 2004.7.8)

                  Source for merge of: l(2)s5379 CG7085

                  (FlyBase, 1996-)

                  Source for merge of: sau rti

                  (Sechi et al., 2014)
                  Additional comments

                  Source for merge of l(2)s5379 BcDNA:LD10657 was a shared cDNA ( date:030728 ).

                  (FlyBase, 1996-)

                  Source for merge of l(2)s5379 CG7085 was a shared cDNA ( date:030206 ).

                  (FlyBase, 1996-)
                  Nomenclature History
                  Source for database identify of

                  Source for identity of: rti l(2)s5379

                  (Chang et al., 2013)
                  Nomenclature comments
                  Etymology

                  The gene is named "rotini" as the twisted phenotype of mutant embryos resembles a type of pasta.

                  (Chang et al., 2013)
                  Synonyms and Secondary IDs (15)
                  Datasets (0)
                  Study focus (0)
                  Experimental Role
                  Project
                  Project Type
                  Title
                  Study result (0)
                  Result
                  Result Type
                  Title
                  External Crossreferences and Linkouts ( 44 )
                  Sequence Crossreferences
                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                  GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                  GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                  RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                  UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                  UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                  UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                  Other crossreferences
                  AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                  BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                  DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                  EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                  FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                  InterPro - A database of protein families, domains and functional sites
                  KEGG Genes - Molecular building blocks of life in the genomic space.
                  MARRVEL_MODEL - MARRVEL (model organism gene)
                  Linkouts
                  Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                  DroID - A comprehensive database of gene and protein interactions.
                  Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                  FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                  FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                  Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                  iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                  MIST (protein-protein) - An integrated Molecular Interaction Database
                  References (64)