FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Ir76b2
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General Information
Symbol
Dmel\Ir76b2
Species
D. melanogaster
Name
FlyBase ID
FBal0285655
Feature type
allele
Associated gene
Dmel\Ir76b
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Zhang et al., 2013)
Progenitor genotype
P{UAST-YFP.Rab39.S23N}Ir76b05
(Zhang et al., 2013)
Cytology
Description

Imprecise excision of the progenitor insertion, resulting in a deletion of Ir76b sequences.

(Zhang et al., 2013)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Adults with homozygous Ir76b2 have proboscis extension rates that are significantly reduced in response to fatty acids, but not in response to sucrose, compared to controls.

      (Ahn et al., 2017)

      Ir76b1/Ir76b2 adult females have significantly reduced preference for oviposition on acid-containing medium, compared to controls.

      (Chen and Amrein, 2017)

      Ir76b2/Ir76b2 mutant females exhibit significant reductions in the feeding preference indices for yeast extract and for each of the individual amino acids serine, phenylalanine, alanine, threonine and glycine; but no significant change in feeding preference index for sucrose, as compared to wild type. L-type labellar sensilla in Ir76b2/Ir76b2 mutants fail to respond to salt (NaCl) stimulus, in contrast to wild type.

      Expression of Ir76bScer\UAS.cAa under the control of Scer\GAL4Gr5a.8.5 in a Ir76b2/Ir76b2 mutant background is not sufficient to confer sensitivity of sweet-taste neurons in L-type sensilla to a mixture of serine, threonine and phenylalanine, in a taste response assay with responses measured by single sensillum recordings.

      (Ganguly et al., 2017)

      In olfactory preference assays for polyamines, Ir76b2/Ir76b2 flies show a significant decrease in their attraction to putrescine or cadaverine, as compared to wild type. Ir76b2/Ir76b2 females display a loss of aversion to oviposit on polyamine-rich substrate (plain, sugar-free 1% agarose supplemented with either putrescine or cadaverine) versus non-supplemented substrate, in contrast to wild type flies, instead showing no preference for either substrate.

      (Hussain et al., 2016)

      Mutant flies show severe defects in attraction to low salt concentrations, while aversion to high salt concentrations is normal. There is a significant decrease in the frequency of action potentials elicited by 50mM NaCl in the L4 sensilla compared to wild type, while the electrophysiological response of the S6 sensilla to 50mM NaCl is normal.

      (Zhang et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      In a taste response assay with responses measured by single sensillum recordings, co-expression of Ir76bScer\UAS.cAa and Ir20aScer\UAS.cGa under the control of Scer\GAL4Gr5a.8.5 in a Ir76b2/Ir76b2 mutant background leads to sweet-taste neurons in L-type sensilla becoming sensitive to a mixture of serine, threonine and phenylalanine, in contrast to controls; and suppresses the response to salt in sweet-taste neurons of L-type labellar sensilla, as compared to Ir76b2/Ir76b2 mutants expressing Ir76bScer\UAS.cAa alone.

      (Ganguly et al., 2017)
      Xenogenetic Interactions
      Statement
      Reference

      Expression of Agam\Ir76bScer\UAS.cGa under the control of Scer\GAL4Ir76b.916 rescues the decreased feeding preferences for yeast extract, serine, phenylalanine, alanine, threonine or glycine seen in Ir76b2/Ir76b2 mutant females.

      (Ganguly et al., 2017)
      Complementation and Rescue Data
      Rescued by

      Ir76b2 is rescued by Scer\GAL4Gr64f.9.7/Ir76bUAS.cZa

      (Ahn et al., 2017)
      Partially rescued by

      Ir76b1/Ir76b2 is partially rescued by Ecol\lexAGr66a.PS/Scer\GAL80lexAop.cTa/Scer\GAL4Ir76b.1.5/Ir76bUAS.cZa/Ecol\lexAVP16.Gr64f

      (Chen and Amrein, 2017)

      Ir76b2 is partially rescued by Scer\GAL4Ir76b.916/Ir76bUAS.cAa

      (Ganguly et al., 2017)
      Comments

      Expression of Ir76bScer\UAS.cAa under the control of Scer\GAL4Ir76b.916 rescues the decreased feeding preferences for yeast extract, serine, phenylalanine, alanine, threonine and glycine seen in Ir76b2/Ir76b2 mutant females; and partially rescues the loss of sweet-taste neuron response to salt in L-type labellar sensilla in these mutants.

      (Ganguly et al., 2017)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      References (19)