FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Ir76bUAS.cZa
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General Information
Symbol
Dmel\Ir76bUAS.cZa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Zhang
FlyBase ID
FBal0285658
Feature type
allele
Associated gene
Dmel\Ir76b
Associated Insertion(s)
Carried in Construct
P{UAS-Ir76b.Z}
Also Known As
UAS-Ir76b
Key Links
Transgenic product class
cDNA
(Zhang et al., 2013)
wild_type
(Zhang et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Zhang et al., 2013)
wild_type
(Zhang et al., 2013)
Mutagen
in vitro construct
(Zhang et al., 2013)
Progenitor genotype
Carried in construct
P{UAS-Ir76b.Z}
Cytology
Description

UASt regulatory sequences drive expression of the full-length Ir76b IP13656 cDNA clone.

(Zhang et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Ir76b
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Ir76bScer\UAS.cZa under the control of Scer\GAL4Gr5a.PUn in a Ir76b1 background results in the Gr5a gustatory receptor neurons in the L2 sensilla showing a robust electrophysiological response to NaCl.

      (Zhang et al., 2013)

      Expression of Ir76bScer\UAS.cZa under the control of Scer\GAL4Gr5a.PUn in a Ir76b1 background results in the Gr5a gustatory receptor neurons in the L2 sensilla showing a robust electrophysiological response to NaCl. These sensilla show no response to NMDGCl (indicating that the response to 50Mm NaCl is due to Na[+]). The response of these sensilla to 50mM sucrose is not significantly different from wild type.

      (Zhang et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4Ir76b.1.5/Ir76bUAS.cZa rescues Ir76b1

      (Pradhan et al., 2025)

      Ir76bUAS.cZa/Scer\GAL4Gr33a-GAL4 rescues Ir76b1

      (Pradhan et al., 2025)

      Scer\GAL4Ir76b.1.5/Ir76bUAS.cZa rescues Ir76b1

      (Pradhan et al., 2024)

      Ir76bUAS.cZa/Scer\GAL4Gr33a-GAL4 rescues Ir76b1

      (Pradhan et al., 2024)

      Scer\GAL4Ir76b.1.5/Ir76bUAS.cZa rescues Ir76b1

      (Sang et al., 2024)

      Scer\GAL4Ir60b.PK/Ir76bUAS.cZa rescues Ir76b1

      (Sang et al., 2024)

      Scer\GAL4Gr64f.9.7/Ir76bUAS.cZa rescues Ir76b2

      (Ahn et al., 2017)

      Scer\GAL4Ir76b.916/Ir76bUAS.cZa rescues Ir76b1

      (Croset et al., 2016)

      Scer\GAL4Ir76b.916/Ir76bUAS.cZa rescues Ir76b1

      (Hussain et al., 2016)

      Ir76bUAS.cZa/Scer\GAL4Gr5a.PUn rescues Ir76b1

      (Zhang et al., 2013)

      Scer\GAL4Ir76b.1.5/Ir76bUAS.cZa rescues Ir76b1

      (Zhang et al., 2013)
      Partially rescues

      Scer\GAL4Ir76b.1.5/Ir76bUAS.cZa partially rescues Ir76b1

      (Ahn et al., 2017)

      Scer\GAL4Ir76b.1.5/Ir76bUAS.cZa partially rescues Ir76b1

      (Chen and Amrein, 2017)

      Ecol\lexAGr66a.PS, Scer\GAL80lexAop.cTa, Scer\GAL4Ir76b.1.5, Ir76bUAS.cZa, Ecol\lexAVP16.Gr64f partially rescues Ir76b1/Ir76b2

      (Chen and Amrein, 2017)

      Scer\GAL4Ir41a.2474/Ir76bUAS.cZa partially rescues Ir76b1

      (Hussain et al., 2016)
      Fails to rescue

      Scer\GAL4Gr66a.PU/Ir76bUAS.cZa fails to rescue Ir76b1

      (Hussain et al., 2016)
      Comments

      Expression of Ir76bScer\UAS.cZa under the control of Scer\GAL4Ir76b.916 or Scer\GAL4Ir41a.2474 restores the olfactory preference for putrescine in Ir76b1/Ir76b1 mutant flies. Expression of Ir76bScer\UAS.cZa under the control of Scer\GAL4Ir76b.916, but not Scer\GAL4Ir41a.2474 or Scer\GAL4Gr66a.PU, restores the oviposition aversion to putrescine-containing substrate shown by female Ir76b1/Ir76b1 mutants.

      (Hussain et al., 2016)

      Expression of Ir76bScer\UAS.cZa under the control of Scer\GAL4Ir76b.1.5 rescues the behavioral and electrophysiological defects seen in Ir76b1 flies in response to low salt concentrations.

      Expression of Ir76bScer\UAS.cZa under the control of Scer\GAL4Gr5a.PUn rescues the defect in low-salt preference which is seen in Ir76b1 flies.

      (Zhang et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Ir76bScer\UAS.cZa
      Ir76bUAS.cZa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Zhang
      Secondary FlyBase IDs
        References (18)