FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\AdamTS-AE439A.UAS
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General Information
Symbol
Dmel\AdamTS-AE439A.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0286144
Feature type
allele
Associated gene
Dmel\AdamTS-A
Associated Insertion(s)
Carried in Construct
P{UAS-AdamTS-A.E439A}
Also Known As
UAS-AdamTS-AE439A
Key Links
Transgenic product class
missense_variant
(Ismat et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Ismat et al., 2013)
Mutagen
in vitro construct
(Ismat et al., 2013)
Progenitor genotype
Carried in construct
P{UAS-AdamTS-A.E439A}
Cytology
Description

UAS regulatory sequences drive expression of an enzyme-dead version of AdamTS-A (contains the amino acid replacement E439A).

(Ismat et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
AdamTS-A
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of AdamTS-AE439A.UAS under the control of Scer\GAL4elav.PU (combined with Scer\GAL80repo.PL) does not cause any morphological defects in larval brain but expression driven by Scer\GAL4repo results in elongated ventral nerve cord.

      (Skeath et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      AdamTS-AE439A.UAS/Scer\GAL4repo partially rescues AdamTS-Arnwy2/AdamTS-Arnwy1

      (Skeath et al., 2017)
      Fails to rescue

      AdamTS-AE439A.UAS/Scer\GAL4tey-5053A fails to rescue AdamTS-AKO/Df(3R)88F5

      (Ismat et al., 2013)
      Comments

      Expression of AdamTS-AE439A.UAS under the control of Scer\GAL4repo partially rescues the neural invasion phenotype (neural cells from the brain invade adjacent peripheral structures such as imaginal discs) observed in AdamTS-Arnwy1/AdamTS-Arnwy2 larval brain: ~45% of larvae exhibit modest invasion phenotype. However, all the larvae show abnormal elongation of the ventral nerve cord.

      (Skeath et al., 2017)

      Expression of AdamTS-AE439A.Scer\UAS under the control of Scer\GAL4tey-5053A fails to rescue the caudal visceral mesoderm migration defects seen in AdamTS-AKO/Df(3R)88F5 embryos.

      (Ismat et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      AdamTS-AE439A.Scer\UAS
      AdamTS-AE439A.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (3)