Expression of Hsap\SOD1^{D83S.Scer\UAS} under the control of Scer\GAL4^da.G32 has no effect on adult lifespan. No gross anatomical degeneration of the brain or retina is seen, even in 60 day old flies.

Flies expressing Hsap\SOD1^{D83S.Scer\UAS} under the control of Scer\GAL4^da.G32 show normal locomotor activity at 10 days of age, but have significantly compromised locomotor activity at 30 days of age.

Expression of Hsap\SOD1^{D83S.Scer\UAS} under the control of Scer\GAL4^da.G32 results in a localised rearrangement of cristae within individual mitochondria in the indirect flight muscles. These rearrangements are seen in both 10 day and 30 day old flies, with the defect being more severe in 30 days old flies.

Expression of Hsap\SOD1^{D83S.Scer\UAS} under the control of either Scer\GAL4^elav.PU, Scer\GAL4^repo.PU or Scer\GAL4^Mhc.PU has no major effect on longevity. Expression of Hsap\SOD1^{D83S.Scer\UAS} under the control of Scer\GAL4^D42 results in a moderate decrease in lifespan.

Expression of Hsap\SOD1^{D83S.Scer\UAS} under the control of either Scer\GAL4^elav.PU or Scer\GAL4^repo.PU, but not under the control of Scer\GAL4^Mhc.PU or Scer\GAL4^D42 results in a decrease in locomotor activity in 30 day old flies.

Flies expressing Hsap\SOD1^{D83S.Scer\UAS} under the control of Scer\GAL4^elav.PU show increased sensitivity to paraquat compared to controls. These flies show decreased tolerance to zinc but not to copper or iron compared to controls.

Hsap\SOD1^D83S.UAS, Scer\GAL4^elav.PU has abnormal locomotor behavior | adult stage phenotype, suppressible by Scer\NDI1^UAS.cBa, Scer\GAL4^elav.PU