Internal deletion within the P{PZ}DrJ375 insertion (genomic D sequence is unaffected). The deletion spans 10.1kb and extends from nucleotides 4889 to 14526 of the P{PZ} element, removing the ry+t7.2 marker and most of the 3' P-element repeat.
Homozygotes show 8.9% viability. Viability of transheterozygotes is as follows: D89/D107 - 71.2%, D89/D175 - 32.8%, D3/D89 - 2.7%.
Mutant adult brains show defects in dendritic patterns of Scer\GAL4Mz19-expressing projection neurons (PNs) in approximately 35% of cases. In some flies, only a single glomerulus is innervated. Although it is often aberrantly shaped, the location is generally in a position consistent with DA1. In other cases, the dendrites show ectopic innervation of glomeruli that are generally adjacent to VA1d and frequently include VA1lm. The Scer\GAL4Mz19-expressing PNs are occasionally spatially restricted within a glomerulus in contrast to wild type where they generally fill the entire glomerulus volume. In approximately 10% of mutant brains, the axons of the Scer\GAL4Mz19-expressing PNs follow abnormal routes to the lateral horn. The aberrant trajectories resemble the middle antenno-cerebral tract (mACT) except that the mutant PN axons extend a long off-shoot from this path mACT-like path that arborises in the mushroom body. In 50% of cases the axons follow the wild-type path to the lateral horn but show atypical secondary and/or tertiary branches within the lateral horn.
The cell bodies of Scer\GAL4c305a-expressing local interneurons are slightly displaced to a more anterodorsal position in mutant brains.
Or47b-expressing olfactory receptor neuron (ORN) axons show aberrant ipsilateral innervation of both the VA1lm and a neighbouring glomerulus (possibly VA1d) in approximately 50% of mutant brains. Or47b- and Or88a-expressing ORN axons fail to cross the midline in more than 40% of mutant brains.