FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\HtrA2S266A.UAS
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General Information
Symbol
Dmel\HtrA2S266A.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0288460
Feature type
allele
Associated gene
Dmel\HtrA2
Associated Insertion(s)
Carried in Construct
P{UAS-HtrA2.S266A}
Key Links
Transgenic product class
missense_variant
(Yun et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Yun et al., 2008)
Mutagen
in vitro construct
(Yun et al., 2008)
Progenitor genotype
HtrA2UAS.cYa
(Yun et al., 2008)
Carried in construct
P{UAS-HtrA2.S266A}
Cytology
Description

UASt regulatory sequences drive expression of a mutant form of HtrA2 in which the serine at amino acid 266 has been replaced by alanine.

(Yun et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
HtrA2
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      No eye phenotypes are observed when HtrA2S266A.Scer\UAS is expressed under the control of Scer\GAL4GMR.PF.

      The indirect flight muscles appear normal when HtrA2S266A.βTub85D is expressed under the control of Scer\GAL4Mef2.PR.

      (Yun et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhancer of
      Statement
      Reference

      HtrA2S266A.UAS, Scer\GAL4GMR.PF is a non-enhancer of visible phenotype of Pink1UAS.cCa, Scer\GAL4GMR.PF

      (Yun et al., 2008)
      Phenotype Manifest In
      NOT Enhancer of
      Statement
      Reference

      HtrA2S266A.UAS, Scer\GAL4GMR.PF is a non-enhancer of eye phenotype of Pink1UAS.cCa, Scer\GAL4GMR.PF

      (Yun et al., 2008)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of HtrA2S266A.Scer\UAS does not enhance the rough eye phenotype seen when Pink1Scer\UAS.cCa is expressed under the control of Scer\GAL4GMR.PF at 18[o]C.

      (Yun et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      HtrA2S266A.Scer\UAS
      HtrA2S266A.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)