FlyBase Allele Report: Dmel\egh[UAS.Tag:MYC]

General Information

Symbol

Dmel\egh^UAS.Tag:MYC

Species

D. melanogaster

Name

FlyBase ID

FBal0294182

Feature type

allele

Associated gene

Dmel\egh

Associated Insertion(s)

Carried in Construct

P{UAS-egh.Myc}

Also Known As

UAS-Egh

Key Links

Transgenic product class

wild_type

(Dahlgaard et al., 2012)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Dahlgaard et al., 2012)

Mutagen

in vitro construct

(Dahlgaard et al., 2012)

Progenitor genotype

Carried in construct

P{UAS-egh.Myc}

Cytology

Description

UAS regulatory sequences drive expression of egh tagged with Tag:MYC.

(Dahlgaard et al., 2012)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

egh

Tagged with

Tag:MYC

epitope tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | larval stage, with Scer\GAL4^nSyb.PS

(Huang et al., 2018)

abnormal neuroanatomy | larval stage, with Scer\GAL4^RapGAP1-OK6

(Huang et al., 2018)

Phenotype Manifest In

embryonic/larval neuromuscular junction, with Scer\GAL4^nSyb.PS

(Huang et al., 2018)

embryonic/larval neuromuscular junction, with Scer\GAL4^RapGAP1-OK6

(Huang et al., 2018)

terminal bouton | larval stage, with Scer\GAL4^nSyb.PS

(Huang et al., 2018)

terminal bouton | larval stage, with Scer\GAL4^RapGAP1-OK6

(Huang et al., 2018)

Detailed Description

Statement

Reference

Expression of egh^UAS.Tag:MYC under the control of Scer\GAL4^nSyb.PS or Scer\GAL4^RapGAP1-OK6, but not Scer\GAL4^C57 or Scer\GAL4^repo, significantly increases bouton number, significantly reduces bouton size, and increases satellite bouton number at the neuromuscular junction of muscle 4, compared to controls.

(Huang et al., 2018)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

egh^UAS.Tag:MYC/Scer\GAL4^nSyb.PS is a non-enhancer of abnormal neuroanatomy | larval stage phenotype of wg¹

(Huang et al., 2018)

egh^UAS.Tag:MYC/Scer\GAL4^nSyb.PS is a non-enhancer of abnormal neuroanatomy | larval stage phenotype of wg¹/wg^GBM

(Huang et al., 2018)

NOT Suppressor of

Statement

Reference

egh^UAS.Tag:MYC/Scer\GAL4^nSyb.PS is a non-suppressor of abnormal neuroanatomy | larval stage phenotype of wg¹/wg^GBM

(Huang et al., 2018)

egh^UAS.Tag:MYC/Scer\GAL4^nSyb.PS is a non-suppressor of abnormal neuroanatomy | larval stage phenotype of wg¹

(Huang et al., 2018)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

egh^UAS.Tag:MYC/Scer\GAL4^nSyb.PS is a non-enhancer of embryonic/larval neuromuscular junction phenotype of wg¹

(Huang et al., 2018)

egh^UAS.Tag:MYC/Scer\GAL4^nSyb.PS is a non-enhancer of terminal bouton | larval stage phenotype of wg¹

(Huang et al., 2018)

egh^UAS.Tag:MYC/Scer\GAL4^nSyb.PS is a non-enhancer of embryonic/larval neuromuscular junction phenotype of wg¹/wg^GBM

(Huang et al., 2018)

egh^UAS.Tag:MYC/Scer\GAL4^nSyb.PS is a non-enhancer of terminal bouton | larval stage phenotype of wg¹/wg^GBM

(Huang et al., 2018)

NOT Suppressor of

Statement

Reference

egh^UAS.Tag:MYC/Scer\GAL4^nSyb.PS is a non-suppressor of embryonic/larval neuromuscular junction phenotype of wg¹/wg^GBM

(Huang et al., 2018)

egh^UAS.Tag:MYC/Scer\GAL4^nSyb.PS is a non-suppressor of terminal bouton | larval stage phenotype of wg¹/wg^GBM

(Huang et al., 2018)

egh^UAS.Tag:MYC/Scer\GAL4^nSyb.PS is a non-suppressor of embryonic/larval neuromuscular junction phenotype of wg¹

(Huang et al., 2018)

egh^UAS.Tag:MYC/Scer\GAL4^nSyb.PS is a non-suppressor of terminal bouton | larval stage phenotype of wg¹

(Huang et al., 2018)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

egh^UAS.Tag:MYC is partially rescued by egh^62d18/Scer\GAL4^nSyb.PS

(Huang et al., 2018)

Rescues

egh^UAS.Tag:MYC/Scer\GAL4^Act5C.PI rescues egh^62d18

(Dahlgaard et al., 2012)

egh^UAS.Tag:MYC/Scer\GAL4^Gli-rL82 rescues egh^62d18

(Dahlgaard et al., 2012)

egh^UAS.Tag:MYC/Scer\GAL4^repo rescues egh^62d18

(Dahlgaard et al., 2012)

Partially rescues

egh^UAS.Tag:MYC/Scer\GAL4^nSyb.PS partially rescues egh^62d18

(Huang et al., 2018)

egh^UAS.Tag:MYC/Scer\GAL4^elav.PLu partially rescues egh^62d18

(Dahlgaard et al., 2012)

Fails to rescue

egh^UAS.Tag:MYC/Scer\GAL4^C57 fails to rescue egh⁷

(Huang et al., 2018)

egh^UAS.Tag:MYC/Scer\GAL4^repo fails to rescue egh⁷

(Huang et al., 2018)

egh^UAS.Tag:MYC/Scer\GAL4^eater.PT fails to rescue egh^62d18

(Dahlgaard et al., 2012)

Comments

Ubiquitous expression of egh^{Scer\UAS.T:Hsap\MYC} under the control of any one of Scer\GAL4^Gli-rL82, Scer\GAL4^repo or Scer\GAL4^Act5C.PI efficiently rescues the phenotype of enlargement of peripheral nerves with attached immune cells in egh^62d18 mutants.

(Dahlgaard et al., 2012)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

egh^{Scer\UAS.T:Hsap\MYC}

egh^UAS.Tag:MYC

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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