FlyBase Allele Report: Scer\GAL4[Rab7-Gal4-KO]

General Information

Symbol

Scer\GAL4^Rab7-Gal4-KO

Species

S. cerevisiae

Name

FlyBase ID

FBal0294204

Feature type

allele

Associated gene

Scer\GAL4

Associated Insertion(s)

TI{GAL4}Rab7^Gal4-KO

Carried in Construct

Allele class

Mutagen

ends-out gene targeting

Nature of the Allele

Allele class

Mutagen

ends-out gene targeting

(Cherry et al., 2013)

Progenitor genotype

Associated Insertion(s)

TI{GAL4}Rab7^Gal4-KO

Cytology

Description

The Rab7 open reading frame has been replaced by a cassette containing sequence encoding a GAL4 driver and a Disc\RFP^3xP3.PC marker.

(Cherry et al., 2013)

Allele components

Component

Use(s)

Inserted element

TI{GAL4}

promoter trap

Encoded product / tool

GAL4

binary expression system - driver

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive, with Rab7^{Q67L.UAS.Venus}

(Cherry et al., 2013)

viable, with Rab7^{K157N.UAS.Venus}

(Cherry et al., 2013)

viable, with Rab7^{L129F.UAS.Venus}

(Cherry et al., 2013)

viable, with Rab7^{N161T.UAS.Venus}

(Cherry et al., 2013)

viable, with Rab7^{T22N.UAS.Venus}

(Cherry et al., 2013)

viable, with Rab7^UAS.Venus

(Cherry et al., 2013)

viable, with Rab7^{V162M.UAS.Venus}

(Cherry et al., 2013)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\GAL4^Rab7-Gal4-KO/Hsap\RAB7A^UAS.Venus is a suppressor of abnormal neurophysiology | dominant phenotype of Rab7^Gal4-KO

(Cherry et al., 2013)

Scer\GAL4^Rab7-Gal4-KO/Hsap\RAB7A^UAS.Venus is a suppressor of lethal - all die before end of pupal stage | recessive phenotype of Rab7^Gal4-KO

(Cherry et al., 2013)

Scer\GAL4^Rab7-Gal4-KO/Hsap\RAB7A^UAS.Venus is a suppressor of abnormal neurophysiology | somatic clone | adult stage | progressive phenotype of Rab7^Gal4-KO

(Cherry et al., 2013)

Scer\GAL4^Rab7-Gal4-KO/Hsap\RAB7A^UAS.Venus is a suppressor of abnormal neuroanatomy | somatic clone | adult stage | progressive phenotype of Rab7^Gal4-KO

(Cherry et al., 2013)

Scer\GAL4^Rab7-Gal4-KO/Hsap\RAB7A^{K157N.UAS.Venus} is a suppressor of abnormal neurophysiology | dominant phenotype of Rab7^Gal4-KO

(Cherry et al., 2013)

Scer\GAL4^Rab7-Gal4-KO/Hsap\RAB7A^{K157N.UAS.Venus} is a suppressor of lethal - all die before end of pupal stage | recessive phenotype of Rab7^Gal4-KO

(Cherry et al., 2013)

Scer\GAL4^Rab7-Gal4-KO/Hsap\RAB7A^{K157N.UAS.Venus} is a suppressor of abnormal neurophysiology | somatic clone | adult stage | progressive phenotype of Rab7^Gal4-KO

(Cherry et al., 2013)

Scer\GAL4^Rab7-Gal4-KO/Hsap\RAB7A^{K157N.UAS.Venus} is a suppressor of abnormal neuroanatomy | somatic clone | adult stage | progressive phenotype of Rab7^Gal4-KO

(Cherry et al., 2013)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Rab7^UAS.Venus/Scer\GAL4^Rab7-Gal4-KO rescues [+]/Rab7^Gal4-KO

(Cherry et al., 2013)

Scer\GAL4^Rab7-Gal4-KO/Rab7^{L129F.UAS.Venus} rescues [+]/Rab7^Gal4-KO

(Cherry et al., 2013)

Scer\GAL4^Rab7-Gal4-KO/Rab7^{K157N.UAS.Venus} rescues [+]/Rab7^Gal4-KO

(Cherry et al., 2013)

Scer\GAL4^Rab7-Gal4-KO/Rab7^{N161T.UAS.Venus} rescues [+]/Rab7^Gal4-KO

(Cherry et al., 2013)

Rab7^{V162M.UAS.Venus}/Scer\GAL4^Rab7-Gal4-KO rescues [+]/Rab7^Gal4-KO

(Cherry et al., 2013)

Scer\GAL4^Rab7-Gal4-KO/Rab7^{Q67L.UAS.Venus} rescues Rab7^Gal4-KO

(Cherry et al., 2013)

Rab7^UAS.Venus/Scer\GAL4^Rab7-Gal4-KO rescues Rab7^Gal4-KO

(Cherry et al., 2013)

Scer\GAL4^Rab7-Gal4-KO/Rab7^{L129F.UAS.Venus} rescues Rab7^Gal4-KO

(Cherry et al., 2013)

Scer\GAL4^Rab7-Gal4-KO/Rab7^{K157N.UAS.Venus} rescues Rab7^Gal4-KO

(Cherry et al., 2013)

Scer\GAL4^Rab7-Gal4-KO/Rab7^{N161T.UAS.Venus} rescues Rab7^Gal4-KO

(Cherry et al., 2013)

Rab7^{V162M.UAS.Venus}/Scer\GAL4^Rab7-Gal4-KO rescues Rab7^Gal4-KO

(Cherry et al., 2013)

Partially rescues

Scer\GAL4^Rab7-Gal4-KO/Rab7^{T22N.UAS.Venus} partially rescues Rab7^Gal4-KO

(Cherry et al., 2013)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Scer\GAL4^Rab7-Gal4-KO

Scer\GAL4^{Rab7.T:Disc\RFP}

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections