FlyBase Allele Report: Dmel\Pu[HMC04085]

General Information

Symbol

Dmel\Pu^HMC04085

Species

D. melanogaster

Name

FlyBase ID

FBal0294642

Feature type

allele

Associated gene

Dmel\Pu

Associated Insertion(s)

Carried in Construct

P{TRiP.HMC04085}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMC04085}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMC04085

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates Parkinson's disease 1

modeled by Hsap\SNCA^QUAS.cOa

(Sarkar et al., 2020)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Expressing Pu^HMC04085 under the control of Scer\GAL4^Cg.PA does not seem to lead to mitochondrial defects in the third instar larval fat body (as assessed by MitoGFP).

(Zhou et al., 2019)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Pu^HMC04085/Scer\GAL4^nSyb.PU is an enhancer of abnormal locomotor behavior | adult stage phenotype of Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb

(Sarkar et al., 2020)

Pu^HMC04085, Scer\GAL4^Cg.PA is an enhancer of abnormal size | third instar larval stage phenotype of Dhpr^HMC05508, Scer\GAL4^Cg.PA

(Zhou et al., 2019)

NOT Enhancer of

Statement

Reference

Pu^HMC04085/Scer\GAL4^repo.PU is a non-enhancer of abnormal locomotor behavior | adult stage phenotype of Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb

(Sarkar et al., 2020)

Suppressor of

Statement

Reference

Scer\GAL4^Cg.PA, Pu^HMC04085/Drp1^UAS.cDa is a suppressor | partially of abnormal size | third instar larval stage phenotype of Dhpr^HMC05508, Scer\GAL4^Cg.PA

(Zhou et al., 2019)

NOT Suppressor of

Statement

Reference

Pu^HMC04085/Scer\GAL4^repo.PU is a non-suppressor of abnormal locomotor behavior | adult stage phenotype of Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb

(Sarkar et al., 2020)

Phenotype Manifest In

Enhancer of

Statement

Reference

Pu^HMC04085, Scer\GAL4^Cg.PA is an enhancer of mitochondrion | third instar larval stage phenotype of Dhpr^HMC05508, Scer\GAL4^Cg.PA

(Zhou et al., 2019)

Pu^HMC04085, Scer\GAL4^Cg.PA is an enhancer of embryonic/larval fat body | third instar larval stage phenotype of Dhpr^HMC05508, Scer\GAL4^Cg.PA

(Zhou et al., 2019)

Suppressor of

Statement

Reference

Scer\GAL4^Cg.PA, Pu^HMC04085/Drp1^UAS.cDa is a suppressor | partially of mitochondrion | third instar larval stage phenotype of Dhpr^HMC05508, Scer\GAL4^Cg.PA

(Zhou et al., 2019)

Scer\GAL4^Cg.PA, Pu^HMC04085/Drp1^UAS.cDa is a suppressor | partially of embryonic/larval fat body | third instar larval stage phenotype of Dhpr^HMC05508, Scer\GAL4^Cg.PA

(Zhou et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Pu^HMC04085

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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