FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\LRRK2G2019S.UAS.cMa
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General Information
Symbol
Hsap\LRRK2G2019S.UAS.cMa
Species
H. sapiens
Name
FlyBase ID
FBal0295339
Feature type
allele
Associated gene
Hsap\LRRK2
Associated Insertion(s)
Carried in Construct
P{UAS-LRRK2.G2019S.M}
Key Links
Transgenic product class
missense_variant
(Macleod et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Macleod et al., 2013)
Mutagen
in vitro construct
(Macleod et al., 2013)
Progenitor genotype
Carried in construct
P{UAS-LRRK2.G2019S.M}
Cytology
Description

UAS regulatory sequences drive expression of a mutated form of Hsap\LRRK2 which contains the familial Parkinson's disease-associated G2019S mutation.

(Macleod et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Hsap\LRRK2
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  Parkinson's disease
      CEA
      (Macleod et al., 2013)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      model of  Parkinson's disease
      is ameliorated by Rab32Q79L.UASp.YFP
      (Macleod et al., 2013)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      This allele represents a human variant implicated in disease.
      (Macleod et al., 2013)
      LRRK2:p.Gly2019Ser
      (FlyBase curators, 2019-)
      Variants Synonym(s)
      Associated human disease model(s)
      External database links
      ClinVar: LRRK2_1940
      Comments concerning this variant
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies expressing Hsap\LRRK2G2019S.Scer\UAS.cMa under the control of either Scer\GAL4ple.PF or Scer\GAL4Ddc.PL show a reduced lifespan compared to controls. 5 day old flies expressing Hsap\LRRK2G2019S.Scer\UAS.cMa under the control of Scer\GAL4ple.PF exhibit loss of dorsomedial posterior protocerebral (PPM1) and dorsolateral posterior protocerebral (PPL1) dopaminergic neurons, ascompared to controls.

      (Macleod et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Co-expression of ltdQ79L.Scer\UAS.P\T.T:Avic\GFP-YFP rescues the reduced lifespan and loss of dorsomedial posterior protocerebral and dorsolateral posterior protocerebral dopaminergic neurons seen in flies expressing Hsap\LRRK2G2019S.Scer\UAS.cMa under the control of Scer\GAL4ple.PF.

      (Macleod et al., 2013)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsap\LRRK2G2019S.Scer\UAS.cMa
      Hsap\LRRK2G2019S.UAS.cMa
      Name Synonyms
      Secondary FlyBase IDs
        References (2)