FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\SNCAIPUAS.cLa
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General Information
Symbol
Hsap\SNCAIPUAS.cLa
Species
H. sapiens
Name
Saccharomyces cerevisiae UAS construct of Liu
FlyBase ID
FBal0295757
Feature type
allele
Associated gene
Hsap\SNCAIP
Associated Insertion(s)
Carried in Construct
P{UAS-SP1.L}
Also Known As
UAS-SP1
Key Links
Transgenic product class
cDNA
(Liu et al., 2012)
wild_type
(Liu et al., 2012)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Liu et al., 2012)
wild_type
(Liu et al., 2012)
Mutagen
in vitro construct
(Liu et al., 2012)
Progenitor genotype
Carried in construct
P{UAS-SP1.L}
Cytology
Description

UAS regulatory sequences drive expression of a Hsap\SNCAIP cDNA.

(Liu et al., 2012)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Hsap\SNCAIP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  obesity
      CEA
      (Liu et al., 2021, Liu et al., 2012)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Parkinson's disease
      modeled by Hsap\LRRK2G2019S.UAS.Tag:FLAG
      (Liu et al., 2016)
      model of  obesity
      is ameliorated by AMPKαGL00004
      (Liu et al., 2021)
      is ameliorated by AMPKαHMS00362
      (Liu et al., 2021)
      is ameliorated by AMPKαJF01951
      (Liu et al., 2021)
      is ameliorated by AMPKαK57A.UAS
      (Liu et al., 2021)
      is exacerbated by AMPKαT184D.UAS
      (Liu et al., 2021)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Hsap\SNCAIPScer\UAS.cLa under the control of Scer\GAL4Ddc.PU does not result in any neurodegeneration phenotypes, as assessed by survival, climbing assays, and dopaminergic neuron degeneration.

      (Liu et al., 2016)

      Expression of Hsap\SNCAIPScer\UAS.cLa under the control of either Scer\GAL4fru.P1.D, Scer\GAL4TPH.PL, Scer\GAL4Ddc.PL, Scer\GAL4elav.PU or Scer\GAL4Act5C.PU results in adult flies with significantly increased body weight compared to controls at 10 days of age. The effect is seen in both males and females.

      Expression of Hsap\SNCAIPScer\UAS.cLa under the control of either Scer\GAL4Ilp2.PU or Scer\GAL4ppl.PU does not significantly increase the body weight of 10 day old adults compared to controls.

      Expression of Hsap\SNCAIPScer\UAS.cLa under the control of Scer\GAL4Ddc.PL significantly increases total triacylglycerol content in adult flies, but does not alter glycogen content.

      Third instar larvae expressing Hsap\SNCAIPScer\UAS.cLa under the control of Scer\GAL4Ddc.PL have an increased fat content compared to controls (measured using a buoyancy-based density assay).

      Fat body cells of third instar larvae expressing Hsap\SNCAIPScer\UAS.cLa under the control of either Scer\GAL4TPH.PL, Scer\GAL4Ddc.PL or Scer\GAL4Act5C.PU are significantly increased in size compared to control cells. Lipid droplets within the fat body cells are increased in size compared to wild type in third instar larvae expressing Hsap\SNCAIPScer\UAS.cLa under the control of Scer\GAL4Ddc.PL.

      Third instar larvae expressing Hsap\SNCAIPScer\UAS.cLa under the control of either Scer\GAL4TPH.PL, Scer\GAL4Ddc.PL or Scer\GAL4Act5C.PU have a normal body length.

      Expression of Hsap\SNCAIPScer\UAS.cLa under the control of either Scer\GAL4fru.P1.D, Scer\GAL4TPH.PL, Scer\GAL4Ddc.PL or Scer\GAL4elav.PU significantly increases adult food intake compared to controls in a CAFE assay.

      Climbing ability and circadian locomotor activity of adults expressing Hsap\SNCAIPScer\UAS.cLa under the control of Scer\GAL4Ddc.PL is normal.

      Flies expressing Hsap\SNCAIPScer\UAS.cLa under the control of either Scer\GAL4TPH.PL, Scer\GAL4Ddc.PL, Scer\GAL4elav.PU or Scer\GAL4Act5C.PU show increased resistance to starvation compared to controls. This effect is more evident in females than in males.

      (Liu et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhanced by
      Suppressed by
      NOT suppressed by
      Suppressor of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Co-expression of Hsap\SNCAIPScer\UAS.cLa significantly increases survival, improves locomotor impairment, and partially rescues dopaminergic neuron degeneration caused by expression of Hsap\LRRK2G2019S.Scer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4Ddc.PU.

      (Liu et al., 2016)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Hsap\SNCAIPScer\UAS.cLa
      Hsap\SNCAIPUAS.cLa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct of Liu
      Secondary FlyBase IDs
        References (3)