FlyBase Allele Report: Dmel\Sdhaf3[UAS.cNa]

General Information

Symbol

Dmel\Sdhaf3^UAS.cNa

Species

D. melanogaster

Name

FlyBase ID

FBal0298309

Feature type

allele

Associated gene

Dmel\Sdhaf3

Associated Insertion(s)

Carried in Construct

P{UAS-Sdhaf3.N}

Key Links

Transgenic product class

wild_type

(Na et al., 2014)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Na et al., 2014)

Mutagen

in vitro construct

(Na et al., 2014)

Progenitor genotype

Carried in construct

P{UAS-Sdhaf3.N}

Cytology

Description

UAS regulates expression of Sdhaf3.

(Na et al., 2014)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Sdhaf3

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Scer\GAL4^Act5C.PI-mediated expression of Sdhaf3^Scer\UAS.cNa in an otherwise has no significant effect on the resistance of otherwise wild type flies to hyperoxia.

(Na et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Scer\GAL4^Act5C.PI/Sdhaf3^UAS.cNa rescues Sdhaf3^null

(Na et al., 2014)

Partially rescues

Sdhaf3^UAS.cNa/Scer\GAL4^C57 partially rescues Sdhaf3^null

(Na et al., 2014)

Scer\GAL4^elav.PU/Sdhaf3^UAS.cNa partially rescues Sdhaf3^null

(Na et al., 2014)

Fails to rescue

Scer\GAL4^Cg.PA/Sdhaf3^UAS.cNa fails to rescue Sdhaf3^null

(Na et al., 2014)

Scer\GAL4^mex1.2.1/Sdhaf3^UAS.cNa fails to rescue Sdhaf3^null

(Na et al., 2014)

Comments

Scer\GAL4^Act5C.PI-mediated expression of Sdhaf3^Scer\UAS.cNa rescues the hyperoxia sensitivity and climbing defects of Sdhaf3^null mutants, while Scer\GAL4^C57- or Scer\GAL4^elav.PU-mediated expression provides partial rescue.

(Na et al., 2014)

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

76576

w¹¹¹⁸; P{UAS-Sdhaf3.N}2

76577

w¹¹¹⁸; P{UAS-Sdhaf3.N}3

Notes on Origin

Discoverer