FB2026_02 , released June 18, 2026
Allele: Dmel\CycJnull
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General Information
Symbol
Dmel\CycJnull
Species
D. melanogaster
Name
FlyBase ID
FBal0299632
Feature type
allele
Associated gene
Dmel\CycJ
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - genetic evidence

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Atikukke et al., 2014)

amorphic allele - molecular evidence

(Atikukke et al., 2014)
Mutagen
FLPase
(Atikukke et al., 2014)
Progenitor genotype
Caused by aberration
Df(3L)armi-J
Cytology
Description

Complete removal of the CycJ coding region in the Df(3L)armi-J deficiency line.

(Atikukke et al., 2014)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      CycJnull/Df(3L)Exel6095 mutant flies (expressing armi+t6.3 to restore armi[+] function) flies are fertile and lay eggs with normal dorsal appendages, though only 30% of the eggs hatch and develop normally. Very few compound egg chambers (multiple cysts in a single follicular epithelium) are seen.

      (Atikukke et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Other
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      Df(3L)Exel6095/CycJnull, armi+t6.3, aubHN2/aubQC42 has egg chamber phenotype, suppressible by CycJ+t4

      (Atikukke et al., 2014)
      Enhancer of
      Statement
      Reference

      armi+t6.3, Df(3L)Exel6095, CycJnull is an enhancer of egg chamber phenotype of Df(2L)BSC145/piwi06843

      (Atikukke et al., 2014)
      NOT Enhancer of
      Statement
      Reference

      CycJ+t4, armi+t6.3, Df(3L)Exel6095, CycJnull is a non-enhancer of egg chamber phenotype of Df(2L)BSC145/piwi06843

      (Atikukke et al., 2014)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      CycJnull/Df(3L)Exel6095 (expressing armi+t6.3 to restore armi[+] function) enhances the fertility defects seen in aubHN2/aubQC42 mutant females. The resulting flies lay no eggs and oocyte development is arrested, with egg chambers rarely advancing beyond stage 7-8. Compound egg chambers (multiple cysts in a single follicular epithelium) are seen, and these often include a disorganised layer of follicle cells almost separating two fully developed cysts. This phenotype can be fully suppressed by expression of CycJ+t4.

      A CycJnull/Df(3L)Exel6095 mutant background (expressing armi+t6.3 to restore armi[+] function) enhances the oogenesis defects seen in piwi06843/Df(2L)BSC145 mutant females. The frequency of compound egg chambers (multiple cysts in one follicular epithelium) is comparable to that seen in Df(3L)armi-J. Addition of CycJ+t4 decreases the frequency of compound egg chambers to the levels seen in the piwi mutant alone.

      (Atikukke et al., 2014)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      This deficiency has been used as a null allele for CycJ when in combination with armi+t6.3.

      (Atikukke et al., 2014)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      CycJnull
      Name Synonyms
      Secondary FlyBase IDs
        References (1)