FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Plp2KR.Ubi.GFP
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General Information
Symbol
Dmel\Plp2KR.Ubi.GFP
Species
D. melanogaster
Name
FlyBase ID
FBal0299790
Feature type
allele
Associated gene
Dmel\Plp
Associated Insertion(s)
Carried in Construct
P{Ubi-Plp.2KR}
Key Links
Transgenic product class
missense_variant
(Galletta et al., 2014)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Galletta et al., 2014)
Mutagen
in vitro construct
(Galletta et al., 2014)
Progenitor genotype
Carried in construct
P{Ubi-Plp.2KR}
Cytology
Description

A ubiquitin promoter drives expression of full length Plp (isoform PF) containing point mutations at conserved lysine and arginine residues in the CaM Binding Domain 2 which disrupt the interaction of the Plp and Cam proteins. A C-terminal GFP tag is present.

(Galletta et al., 2014)
Allele components
Component
Use(s)
Encoded product / tool
Plp
Tagged with
GFP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Plp2KR.Ubi.GFP rescues Df(3L)Brd15/Plps2172

      (Galletta et al., 2014)
      Fails to rescue

      Plp2KR.Ubi.GFP fails to rescue Df(3L)Brd15/Plps2172

      (Galletta et al., 2014)
      Comments

      Flies remain inviable/incapacitated and centrosome shape in central brain neuroblasts is abnormal, though sperm are motile with normal centrioles in cp309s2172/Df(3L)Brd15 animals expressing cp3092KR.Ubi.T:Avic\GFP.

      (Galletta et al., 2014)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Plp2KR.Ubi.GFP
      Plp2KR.Ubi.T:Avic\GFP
      cp3092KR.Ubi.T:Avic\GFP
      Name Synonyms
      Secondary FlyBase IDs
        References (1)