FlyBase Gene Report: Dmel\Plp

General Information

Symbol

Dmel\Plp

Species

D. melanogaster

Name

Pericentrin-like protein

Annotation Symbol

CG33957

Feature Type

protein_coding_gene

FlyBase ID

FBgn0086690

Gene Model Status

Current

Stock Availability

13 publicly available

Gene Summary

Pericentrin-like protein (Plp) encodes a protein localized to centrioles and centrosomes that plays an important role together with the product of cnn in organizing the pericentriolar material of the centrosome during interphase. It is also required for proper cilium function. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Interactive Fly

Also Known As

D-PLP, cp309, PACT, DPLP, l(3)s2172

Key Links

Genomic Location

Cytogenetic map

71B2-71B4

Sequence location

3L:15,066,081..15,094,724 [-]

Recombination map

3-42

RefSeq locus

NT_037436 REGION:15066081..15094724

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (9 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables protein binding

inferred from physical interaction with FLYBASE:Sas-4; FB:FBgn0011020

(Gopalakrishnan et al., 2011)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables molecular adaptor activity

inferred from electronic annotation with InterPro:IPR028745

(InterPro Project Members, 2004-)

Biological Process (5 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

involved_in centrosome cycle

inferred from mutant phenotype

(Galletta et al., 2014, Dobbelaere et al., 2008)

involved_in cilium-dependent cell motility

inferred from mutant phenotype

(Martinez-Campos et al., 2004)

involved_in microtubule nucleation

inferred from direct assay

(Kawaguchi and Zheng, 2004)

involved_in sensory perception of sound

inferred from mutant phenotype

(Martinez-Campos et al., 2004)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in microtubule nucleation

inferred from biological aspect of ancestor with PANTHER:PTN002894790

(GO Reference Genome Project, 2011-)

involved_in signal transduction

inferred from electronic annotation with InterPro:IPR028745

(InterPro Project Members, 2004-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in centriole

inferred from direct assay

(Gottardo et al., 2016, Galletta et al., 2014, Conduit and Raff, 2010, Martinez-Campos et al., 2004)

located_in ciliary basal body

inferred from direct assay

(Jaiswal et al., 2024, Alzyoud et al., 2021)

inferred from direct assay

(Jana et al., 2018)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Summary (Interactive Fly)

PACT domain protein - associated with both the centrioles and pericentriolar material - essential for the formation of functional cilia and flagella - plays an important role together with cnn in organizing the pericentriolar material of the centrosome during interphase.

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Plp for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q400N2)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Gene model reviewed during 5.56

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Plp-RC

FBtr0099993

NM_001032401

3879

1109

Plp-RD

FBtr0305977

NM_001259832

9110

2767

Plp-RF

FBtr0305979

NM_001032402

9494

2895

Plp-RG

FBtr0333939

NM_001274930

9335

2891

Plp-RH

FBtr0333940

NM_001274931

6175

1757

Plp-RJ

FBtr0333941

NM_001274932

9281

2666

Plp-RK

FBtr0333942

NM_001274933

9302

2831

Plp-RL

FBtr0333943

NM_001274934

9326

2839

Plp-RM

FBtr0333944

NM_001274935

9225

2594

Plp-RN

FBtr0333945

NM_001274936

9233

2650

Plp-RO

FBtr0333946

NM_001274937

6007

1701

Plp-RP

FBtr0333947

NM_001259833

9473

2730

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Plp-PC

FBpp0099787

126.6

1109

6.30

FBpp0297119

312.4

2767

4.62

FBpp0297121

327.3

2895

4.59

FBpp0306064

326.6

2891

4.60

FBpp0306065

200.4

1757

5.41

FBpp0306066

302.1

2666

4.62

FBpp0306067

320.1

2831

4.64

FBpp0306068

320.5

2839

4.59

FBpp0306069

293.9

2594

4.66

FBpp0306070

300.7

2650

4.66

FBpp0306071

193.6

1701

5.52

FBpp0306072

309.8

2730

4.65

M9ND93

NP_001246762

AFH04433

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Plp using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.16

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 5

epithelial cell

• centrosome & spindle microtubule

(Lecuyer et al., 2007)

epithelium

• centrosome & spindle microtubule

(Lecuyer et al., 2007)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

late embryonic stage

chordotonal neuron

• ciliary base

(Chen et al., 2015)

third instar larval stage

adult midgut progenitor cell

• centriole

(Schoenfelder et al., 2014)

salivary gland imaginal ring

• centriole

(Schoenfelder et al., 2014)

oogenesis stage S5

oocyte

• centriole

(Schoenfelder et al., 2014)

oogenesis stage S6 -- S8

follicle cell

• centriole

(Schoenfelder et al., 2014)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 5 of adulthood | male -- day 7 of adulthood | male

spermatozoon

(Wasbrough et al., 2010)

Additional Descriptive Data

Marker for

centriole

(Schoenfelder et al., 2014)

centrosome

(Parma et al., 2007)

Subcellular Localization

CV Term

Evidence

References

located_in centriole

inferred from direct assay

(Gottardo et al., 2016, Galletta et al., 2014, Conduit and Raff, 2010, Martinez-Campos et al., 2004)

located_in ciliary basal body

inferred from direct assay

(Jaiswal et al., 2024, Alzyoud et al., 2021)

inferred from direct assay

(Jana et al., 2018)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Plp in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Plp

View exonic expression by tissue for Dmel\Plp

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

3772382/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0086690

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0086690

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6735

Flygut - An atlas of the Drosophila adult midgut

FBgn0086690

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 14 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 40 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Plp

Transgenic constructs containing regulatory region of Plp

Aberrations (Deficiencies and Duplications) ( 5 )

Inferred from experimentation ( 5 )

Gene disrupted in

Df(3L)Brd15

(Martinez-Campos et al., 2004)

(Ryder, 2004.4.26)

(Ryder, 2004.4.26)

(Ryder, 2004.4.26)

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Inferred from location ( 8 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | larval stage | recessive

Plp^s2172

lethal | recessive

Plp^s2172

partially lethal, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Plp^GD6120

partially lethal (with Df(3L)Brd15)

Plp^s2172

partially lethal - majority die, with Scer\GAL4^pnr-MD237

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

Plp^GD12021

viable (with Df(3L)Brd15)

Other Phenotypes

Allele

abnormal auditory perception

Plp^s2172

abnormal body color, with Scer\GAL4^pnr-MD237

Plp^GD6120

abnormal mitotic cell cycle (with Df(3L)Brd15)

paralytic (with Df(3L)Brd15)

Plp^s2172

some die during embryonic stage | maternal effect

Plp^s2172

some die during pupal stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Plp^GD6120

some die during pupal stage, with Scer\GAL4^pnr-MD237

uncoordinated

Plp^s2172

uncoordinated (with Df(3L)Brd15)

visible, with Scer\GAL4^bbg-C96

visible, with Scer\GAL4^pnr-MD237

Plp^GD6120

Phenotype manifest in

Allele

antennal sense organ & chordotonal organ

Plp^s2172

centriole (with Df(3L)Brd15)

Plp^s2172

centrosome (with Df(3L)Brd15)

centrosome & larval brain

centrosome | cold sensitive (with Df(3L)Brd15)

Plp^s2172

cilium

Plp^s2172

embryonic head & embryonic/first instar larval cuticle | maternal effect

Plp^s2172

embryonic somatic muscle cell | embryonic stage 16

Plp⁵

embryonic somatic muscle cell | embryonic stage 16 (with Df(3L)BSC441)

Plp⁵

mesonotum, with Scer\GAL4^pnr-MD237

Plp^GD6120

neuroblast (with Df(3L)Brd15)

Plp^s2172

nucleus | embryonic stage 16

Plp⁵

nucleus | embryonic stage 16 (with Df(3L)BSC441)

Plp⁵

pericentriolar material (with Df(3L)Brd15)

primary spermatocyte & centriole

primary spermatocyte & nucleus

Plp⁵

primary spermatocyte & spindle

spermatozoon (with Df(3L)Brd15)

Plp^s2172

trichogen cell, with Scer\GAL4^pnr-MD237

Plp^GD6120

wing, with Scer\GAL4^bbg-C96

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (2)

Hsap\PCNT

6 of 14

Yes

Hsap\AKAP9

5 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (2)

Rnor\Pcnt

6 of 14

Yes

Rnor\Akap9

5 of 14

Yes

Mus musculus (laboratory mouse) (2)

Mmus\Akap9

5 of 14

Yes

Mmus\Pcnt

5 of 14

Yes

Xenopus tropicalis (Western clawed frog) (2)

Xtro\pcnt

4 of 13

Yes

Xtro\akap9

3 of 13

Yes

Danio rerio (Zebrafish) (2)

Drer\pcnt

6 of 14

Yes

Drer\akap9

3 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (0)

Anopheles gambiae (African malaria mosquito) (1)

Agam\AgaP_AGAP010655

11 of 12

Yes

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\pcp1

1 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Plp. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 2 )

Human Ortholog

Disease

Evidence

References

PCNT; pericentrin

model of microcephalic osteodysplastic primordial dwarfism type II

IEA

(FlyBase, 2019-)

AKAP9; A-kinase anchoring protein 9

model of long QT syndrome 11

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

PCNT; pericentrin

6 of 14

605925

MICROCEPHALIC OSTEODYSPLASTIC PRIMORDIAL DWARFISM, TYPE II; MOPD2

microcephalic osteodysplastic primordial dwarfism type II

AKAP9; A-kinase anchoring protein 9

5 of 14

604001

LONG QT SYNDROME 11; LQT11

long QT syndrome 11

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

RNA-protein

Physical Interaction

Assay

References

Plp - orb

coimmunoprecipitation, reverse transcription pcr

(Fang and Lerit, 2022)

protein-protein

Physical Interaction

Assay

References

Plp

two hybrid

(Galletta et al., 2016, Richens et al., 2015)

Plp - Cam

phenotype-based detection assay, fluorescence microscopy, inferred by author, anti tag coimmunoprecipitation, anti tag western blot, two hybrid

(Galletta et al., 2014)

Plp - Cep97

two hybrid

(Galletta et al., 2016)

Plp - Cnb

two hybrid

(Ramdas Nair et al., 2016)

Plp - Cp110

two hybrid

(Galletta et al., 2016)

Plp - Cp190

cosedimentation in solution, western blot

(Gopalakrishnan et al., 2011)

Plp - Grip84

anti bait coimmunoprecipitation, western blot

(Kawaguchi and Zheng, 2004)

Plp - Grip91

anti bait coimmunoprecipitation, western blot

(Kawaguchi and Zheng, 2004)

Plp - Khc

isothermal titration calorimetry, predetermined participant, colocalization, fluorescence microscopy, inferred by author, two hybrid

(Hannaford et al., 2022)

Plp - Nek2

two hybrid

(Galletta et al., 2016)

Plp - Sas-4

anti bait coimmunoprecipitation, peptide massfingerprinting, pull down, western blot, cosedimentation through density gradient, two hybrid, anti tag coimmunoprecipitation

(Galletta et al., 2016, Gopalakrishnan et al., 2012, Gopalakrishnan et al., 2011)

Plp - Sas-6

anti tag coimmunoprecipitation, anti tag western blot, pull down, western blot

(Ito et al., 2019)

Plp - ana1

two hybrid

(Galletta et al., 2016)

Plp - ana2

two hybrid

(Galletta et al., 2016)

Plp - asl

anti tag coimmunoprecipitation, anti tag western blot, cosedimentation through density gradient, western blot, two hybrid, anti bait coimmunoprecipitation, cosedimentation in solution

(Galletta et al., 2016, Richens et al., 2015, Gopalakrishnan et al., 2012, Gopalakrishnan et al., 2011, Conduit et al., 2010)

Plp - cnn

two hybrid, cosedimentation through density gradient, western blot, cosedimentation in solution, anti bait coimmunoprecipitation, nuclear magnetic resonance, anti tag western blot

(Citron et al., 2018, Galletta et al., 2016, Lerit et al., 2015, Richens et al., 2015, Gopalakrishnan et al., 2012, Gopalakrishnan et al., 2011, Conduit et al., 2010)

Plp - poe

anti tag coimmunoprecipitation, anti tag western blot, two hybrid

(Galletta et al., 2023)

Plp - spd-2

two hybrid, anti bait coimmunoprecipitation, western blot

(Galletta et al., 2016, Richens et al., 2015, Conduit et al., 2010)

Plp - tacc

two hybrid

(Galletta et al., 2016)

Plp - γTub37C

anti bait coimmunoprecipitation, western blot, molecular sieving, ion exchange chromatography

(Kawaguchi and Zheng, 2004)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

orb

suppressible

Plp

(Fang and Lerit, 2022)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

533979

DroID - A comprehensive database of gene and protein interactions.

FBgn0086690

MIST (protein-protein) - An integrated Molecular Interaction Database

3772382

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Aggrephagy

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-42

Cytogenetic map

71B2-71B4

Sequence location

3L:15,066,081..15,094,724 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

71B2-71B4

Limits computationally determined from genome sequence between P{PZ}l(3)rO220^rO220 and P{EP}Tfb2^EP572

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

71B4-71B5

(determined by in situ hybridisation)

(Spradling et al., 1999, Perrimon et al., 1996)

71B4-71B5

(BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

3-42

(FlyBase, 2016)

3-36.5

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (13)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

23566

w¹¹¹⁸; Mi{ET1}Plp^MB02408

12089

w¹¹¹⁸; P{lacW}Plp^s2172/TM3, Sb¹

9567

ru¹ Plp⁵ st¹/TM6C, Sb¹ Tb¹

65231

y¹ sc^* v¹ sev²¹; P{TRiP.HMC05936}attP40

15826

y¹ w^67c23; P{EPgy2}sstn^EY06542 Plp^EY06542

21206

y¹ w^67c23; P{EPgy2}Plp^EY16376/TM3, Sb¹ Ser¹

6735R-1

13459R-1

13459R-2

18648R-2

v100969

v101645

More stocks available...

Genomic Clones (33)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (133)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

SD04227

Other clones

FI22203

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0086690

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0086690

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Roque et al., 2012, Rogers et al., 2008)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Loss of cp309 causes precocious activation of the mother chromosome and regulates interphase centrosomes by preventing the localisation of γTub23C.

(Lerit and Rusan, 2013)

cp309 blocks centrosome maturation by preventing polo localisation.

(Lerit and Rusan, 2013)

cp309 is required for efficient recruitment of pericentriolar material.

(Dobbelaere et al., 2008)

The autosomal "FLP-DFS" technique (using the P{ovoD1-18} P{FRT(w^hs)} P{hsFLP} chromosomes) has been used to identify the specific maternal effect phenotype for the zygotic lethal mutation.

(Perrimon et al., 1996)

Relationship to Other Genes

Source for database merge of

Source for merge of: cp309 l(3)s2172

(Martinez-Campos et al., 2004)

Additional comments

Annotations CG13459, CG18648 and CG6735 merged as CG33957 (which corresponds to cp309) in release 4.2 of the genome annotation.

(FlyBase Genome Annotators, 2005)

Source for identity of cp309 CG13459 CG6735 was sequence comparison ( date:040205 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: cp309 CG13459 CG6735

(FlyBase, 1996-)

Source for identity of: Plp cp309

(FlyBase, 2009-)

Nomenclature comments

Renamed from 'cp309' to 'Plp'/'Pericentrin-like protein' in order to (i) reflect preferred usage in the literature, (ii) use an more informative nomenclature, and (iii) reduce confusion with other gene groups that use a 'cp/Cp' prefix.

(FlyBase, 2009-)

Etymology

Synonyms and Secondary IDs (33)

Reported As

Symbol Synonym

AKAP450

(Januschke et al., 2005, Rebollo et al., 2004, Gillingham and Munro, 2000)

CG13459

(Dobbelaere et al., 2008, Kawaguchi and Zheng, 2004, Martinez-Campos et al., 2004)

CG18648

(Kawaguchi and Zheng, 2004, Martinez-Campos et al., 2004)

CG33957

(Hosono et al., 2015, Keleman et al., 2009.8.5, Perkins et al., 2009)

CG6735

(Lu et al., 2014, Müller et al., 2010, Kawaguchi and Zheng, 2004, Martinez-Campos et al., 2004, Gillingham and Munro, 2000)

CP309

(Valenzuela et al., 2020, Leibfried et al., 2013, Fabian and Brill, 2012, Ori-McKenney et al., 2012, Lewandowski et al., 2010, Minakhina et al., 2007, Parma et al., 2007, Mirouse et al., 2006, Kawaguchi and Zheng, 2004)

Cp309

(Przewloka et al., 2011, Texada et al., 2008)

D-Plp

(Panda et al., 2020, Dzhindzhev et al., 2017)

DPLP

(Leça et al., 2025, Enjolras et al., 2012, Riparbelli et al., 2012, Januschke et al., 2011, Gervais et al., 2008, Mottier et al., 2008, Rusan and Peifer, 2007)

DPlp

(Lattao et al., 2017, Gottardo et al., 2016, Meghini et al., 2016)

Dplp

(Szikora et al., 2021, Tian et al., 2021, Persico et al., 2020, Fu et al., 2015, Khire et al., 2015, Delgehyr et al., 2012)

PACT

(Fabian and Brill, 2012, Conduit and Raff, 2010, Conduit et al., 2010, Blachon et al., 2009, Martins et al., 2009, Mottier-Pavie and Megraw, 2009, Cheng et al., 2008, Guha et al., 2008, Rodrigues-Martins et al., 2008, Lucas and Raff, 2007, Spradling and Zheng, 2007)

PCNT

(Marthiens and Basto, 2020, Fu et al., 2015)

PLP

(Li et al., 2021, Gartenmann et al., 2020, Ito et al., 2019, Citron et al., 2018, Jana et al., 2018, Reina et al., 2018, Galletta et al., 2016, Gottardo et al., 2016, Pimenta-Marques et al., 2016, Osses and Henríquez, 2014, Sitaram et al., 2014, Lerit and Rusan, 2013, Ahmad et al., 2012, Enjolras et al., 2012, Roque et al., 2012, Van De Bor et al., 2011, Riparbelli et al., 2009)

Pact

(Riparbelli et al., 2020)

cp309

(Mishra et al., 2020, Van Bortle et al., 2015, Ashwal-Fluss et al., 2014, Kwon et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Friedman et al., 2011, Schrider et al., 2011, Müller et al., 2010, Wasbrough et al., 2010, Wasbrough et al., 2010, Ogura et al., 2009, Turner et al., 2008, Kankel et al., 2007, Lecuyer et al., 2007, Müller et al., 2007, Januschke et al., 2006)

d-plp

(Giansanti et al., 2008, Jankovics and Brunner, 2006, Martinez-Campos et al., 2004, Salisbury, 2004)

dPLP

(Venkei et al., 2012, Ma and Jarman, 2011, Przewloka et al., 2011, Texada et al., 2008)

dplp

(Yamashita et al., 2007)

l(3)s2172

(Spradling et al., 1999, Perrimon et al., 1996, BDGP Project Members, 1994-1999)

pPlp

(Castellanos et al., 2008)

plp

(Wong et al., 2025, Hannaford et al., 2022, Mukherjee et al., 2020, Nye et al., 2020, Ryder et al., 2020, Rosen et al., 2019, Galletta et al., 2014)

Name Synonyms

Drosophila Pericentrin Like Protein

(Martins et al., 2010)

Pericentrin

(Cachero et al., 2011)

Pericentrin-like protein

(Ramdas Nair et al., 2016, Yalgin et al., 2015, Lerit and Rusan, 2013, Ahmad et al., 2012, Jankovics and Brunner, 2006, Januschke et al., 2006)

cp309

(Wasbrough et al., 2010)

lethal (3) s2172

pericentrin

(Galletta et al., 2014, Stevens et al., 2010, Wojcik et al., 2004)

pericentrin-like

(Rogers et al., 2009, Giansanti et al., 2008)

pericentrin-like protein

(Enjolras et al., 2012, Fabian and Brill, 2012, Ma and Jarman, 2011, Stevens et al., 2010, Stevens et al., 2009, Yamashita et al., 2007)

pericentrin-like-protein

(Galletta et al., 2014)

pericentrin/AKAP450 centrosomal targeting

(Blachon et al., 2009)

Secondary FlyBase IDs

FBgn0011807
FBgn0053957
FBgn0036475
FBgn0036473
FBgn0036472

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 89 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

3772382

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q400N2

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q400N2

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

3772382/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0086690

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0086690

FlyMine - An integrated database for Drosophila genomics

FBgn0086690

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG33957

MARRVEL_MODEL - MARRVEL (model organism gene)

3772382

Linkouts

BioGRID - A database of protein and genetic interactions.

533979

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0086690

DroID - A comprehensive database of gene and protein interactions.

FBgn0086690

DRSC - Results frm RNAi screens

FBgn0086690

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0086690

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6735

Flygut - An atlas of the Drosophila adult midgut

FBgn0086690

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0086690

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC034159

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (protein-protein) - An integrated Molecular Interaction Database

3772382

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Aggrephagy

References (217)

The following external sites may use different assemblies or annotations than FlyBase.

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