FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\chicoGrb2mutant
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General Information
Symbol
Dmel\chicoGrb2mutant
Species
D. melanogaster
Name
FlyBase ID
FBal0316506
Feature type
allele
Associated gene
Dmel\chico
Associated Insertion(s)
Carried in Construct
P{chico.Grb2mutant}
Key Links
Transgenic product class
missense_variant
(Slack et al., 2015)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Slack et al., 2015)
Mutagen
in vitro construct
(Slack et al., 2015)
Progenitor genotype
Carried in construct
P{chico.Grb2mutant}
Cytology
Description

A 5.6 kb genomic fragment comprising the wild type chico sequence including the cis-regulatory sequences. The proposed binding site for drk has been mutated.

(Slack et al., 2015)
Allele components
Component
Use(s)
Regulatory region(s)
chico
Encoded product / tool
chico
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      chicoGrb2mutant partially rescues chico1

      (Slack et al., 2015)
      Comments

      Expression of chicoGrb2mutant fully restores several phenotypic defects associated with chico1, including developmental delay, reduced growth, female sterility and increased glycogen and lipid storage. The increase in lifespan seen in chico1/+ mutant flies is not rescued.

      (Slack et al., 2015)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      chicoGrb2
      (Fernandes et al., 2017)
      chicoGrb2mutant
      Name Synonyms
      Secondary FlyBase IDs
        References (2)