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Citation
Fernandes, V.M., Chen, Z., Rossi, A.M., Zipfel, J., Desplan, C. (2017). Glia relay differentiation cues to coordinate neuronal development in Drosophila.  Science 357(6354): 886--891.
FlyBase ID
FBrf0236543
Publication Type
Research paper
Abstract

Neuronal birth and specification must be coordinated across the developing brain to generate the neurons that constitute neural circuits. We used the Drosophila visual system to investigate how development is coordinated to establish retinotopy, a feature of all visual systems. Photoreceptors achieve retinotopy by inducing their target field in the optic lobe, the lamina neurons, with a secreted differentiation cue, epidermal growth factor (EGF). We find that communication between photoreceptors and lamina cells requires a signaling relay through glia. In response to photoreceptor-EGF, glia produce insulin-like peptides, which induce lamina neuronal differentiation. Our study identifies a role for glia in coordinating neuronal development across distinct brain regions, thus reconciling the timing of column assembly with that of delayed differentiation, as well as the spatiotemporal pattern of lamina neuron differentiation.

PubMed ID
PubMed Central ID
PMC5835562 (PMC) (EuropePMC)
Related Publication(s)
Note

Glia put visual map in sync.
Isaacman-Beck and Clandinin, 2017, Science 357(6354): 867--868 [FBrf0237051]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Science
    Title
    Science
    Publication Year
    1895-
    ISBN/ISSN
    0036-8075 1095-9203
    Data From Reference