FlyBase Allele Report: Hsap\SNCA[A30P.UAS.cUa]

General Information

Symbol

Hsap\SNCA^A30P.UAS.cUa

Species

H. sapiens

Name

FlyBase ID

FBal0316590

Feature type

allele

Associated gene

Hsap\SNCA

Associated Insertion(s)

Carried in Construct

P{UAS-SNCA.A30P.U}

Key Links

Transgenic product class

missense_variant

(FlyBase Curators, 2025-)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(FlyBase Curators, 2025-)

Mutagen

in vitro construct

(FlyBase Curators, 2025-)

Progenitor genotype

Carried in construct

P{UAS-SNCA.A30P.U}

Cytology

Description

UAS regulatory sequences drive expression of an A30P mutant of Hsap\SNCA.

(FlyBase Curators, 2025-)

FlyBase curator comment: this entry represents a transgenic construct where the particular construct used cannot be determined.

(FlyBase Curators, 2025-)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Hsap\SNCA

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of Parkinson's disease

CEA

(Zhang et al., 2015)

model of Parkinson's disease 1

CEA

(Zhang et al., 2018)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of Parkinson's disease 1

is ameliorated by Hsap\TMEM59^UAS.cLa

(Zhang et al., 2018)

model of Parkinson's disease

is exacerbated by aux^GD7187

(Song et al., 2017)

is exacerbated by aux^KK100927

(Song et al., 2017)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

This allele represents a human variant implicated in disease.

(FlyBase Curators, 2025-)

SNCA:p.Ala30Pro

(FlyBase curators, 2019-)

Variants Synonym(s)

Associated human disease model(s)

Parkinson disease 1

External database links

ClinVar: SNCA_14008

Comments concerning this variant

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | adult stage, with Scer\GAL4^Ddc.PU

(Song et al., 2017)

decreased cell number | adult stage, with Scer\GAL4^Ddc.PU

(Song et al., 2017)

Phenotype Manifest In

dopaminergic PPM1 neuron | adult stage, with Scer\GAL4^Ddc.PU

(Song et al., 2017)

dopaminergic PPM2 neuron | adult stage, with Scer\GAL4^Ddc.PU

(Song et al., 2017)

Detailed Description

Statement

Reference

Expression of Hsap\SNCA^{A30P.Scer\UAS.cUa} under the control of Scer\GAL4^Ddc.PU (but not Scer\GAL4^ple.PU) result in significant loss of dopaminergic neurons from the PPM1/2 cluster even in very young (3 days old) adult flies. This is not due to loss of these neurons during development as their number is comparable to controls in third instar larvae as well as 1 day post-eclosion adults

(Song et al., 2017)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Hsap\SNCA^A30P.UAS.cUa, Scer\GAL4^Ddc.PU has abnormal neuroanatomy | adult stage phenotype, enhanceable by aux^GD7187, Scer\GAL4^Ddc.PU

(Song et al., 2017)

Hsap\SNCA^A30P.UAS.cUa, Scer\GAL4^Ddc.PU has decreased cell number | adult stage phenotype, enhanceable by aux^GD7187, Scer\GAL4^Ddc.PU

(Song et al., 2017)

Hsap\SNCA^A30P.UAS.cUa, Scer\GAL4^Ddc.PU has abnormal neuroanatomy | adult stage phenotype, enhanceable by aux^KK100927, Scer\GAL4^Ddc.PU

(Song et al., 2017)

Hsap\SNCA^A30P.UAS.cUa, Scer\GAL4^Ddc.PU has decreased cell number | adult stage phenotype, enhanceable by aux^KK100927, Scer\GAL4^Ddc.PU

(Song et al., 2017)

Other

Statement

Reference

Hsap\SNCA^A30P.UAS.cUa, Scer\GAL4^ple.PU, aux^GD7187 has abnormal neuroanatomy | adult stage phenotype

(Song et al., 2017)

Hsap\SNCA^A30P.UAS.cUa, Scer\GAL4^ple.PU, aux^GD7187 has decreased cell number | adult stage phenotype

(Song et al., 2017)

Hsap\SNCA^A30P.UAS.cUa, Scer\GAL4^ple.PU, aux^KK100927 has abnormal neuroanatomy | adult stage phenotype

(Song et al., 2017)

Hsap\SNCA^A30P.UAS.cUa, Scer\GAL4^ple.PU, aux^KK100927 has decreased cell number | adult stage phenotype

(Song et al., 2017)

Phenotype Manifest In

Enhanced by

Statement

Reference

Hsap\SNCA^A30P.UAS.cUa, Scer\GAL4^Ddc.PU has dopaminergic PPM1 neuron | adult stage phenotype, enhanceable by aux^GD7187, Scer\GAL4^Ddc.PU

(Song et al., 2017)

Hsap\SNCA^A30P.UAS.cUa, Scer\GAL4^Ddc.PU has dopaminergic PPM2 neuron | adult stage phenotype, enhanceable by aux^GD7187, Scer\GAL4^Ddc.PU

(Song et al., 2017)

Hsap\SNCA^A30P.UAS.cUa, Scer\GAL4^Ddc.PU has dopaminergic PPM1 neuron | adult stage phenotype, enhanceable by aux^KK100927, Scer\GAL4^Ddc.PU

(Song et al., 2017)

Hsap\SNCA^A30P.UAS.cUa, Scer\GAL4^Ddc.PU has dopaminergic PPM2 neuron | adult stage phenotype, enhanceable by aux^KK100927, Scer\GAL4^Ddc.PU

(Song et al., 2017)

Other

Statement

Reference

Hsap\SNCA^A30P.UAS.cUa, Scer\GAL4^ple.PU, aux^GD7187 has dopaminergic PPM2 neuron | adult stage phenotype

(Song et al., 2017)

Hsap\SNCA^A30P.UAS.cUa, Scer\GAL4^ple.PU, aux^GD7187 has dopaminergic PPM1 neuron | adult stage phenotype

(Song et al., 2017)

Hsap\SNCA^A30P.UAS.cUa, Scer\GAL4^ple.PU, aux^KK100927 has dopaminergic PPM2 neuron | adult stage phenotype

(Song et al., 2017)

Hsap\SNCA^A30P.UAS.cUa, Scer\GAL4^ple.PU, aux^KK100927 has dopaminergic PPM1 neuron | adult stage phenotype

(Song et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

The loss of dopaminergic PPM1/2 neurons observed even in very young adult flies expressing Hsap\SNCA^{A30P.Scer\UAS.cUa} under the control of Scer\GAL4^Ddc.PU is exacerbated further by co-expression of either aux^GD7187 or aux^KK100927 RNAi and the number of neurons is further decreased. Simultaneous expression of Hsap\SNCA^{A30P.Scer\UAS.cUa} and either of the two aux RNAi lines and driven by Scer\GAL4^ple.PU also leads to early-onset loss of PPM1/2, which is otherwise not observed in young (3 or 10 days old) flies expressing any of the transgenes alone with this driver. This is not due to loss of these neurons during development as their number is comparable to controls in third instar larvae as well as 1 day post-eclosion adults co-expressing Hsap\SNCA^{A30P.Scer\UAS.cUa} and aux^GD7187 (with Scer\GAL4^ple.PU or Scer\GAL4^Ddc.PU).

(Song et al., 2017)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Hsap\SNCA^{A30P.Scer\UAS.cUa}

Hsap\SNCA^A30P.UAS.cUa

α-Syn^A30P

(Song et al., 2017)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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