FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\S6kUAS.cUa
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General Information
Symbol
Dmel\S6kUAS.cUa
Species
D. melanogaster
Name
FlyBase ID
FBal0316999
Feature type
allele
Associated gene
Dmel\S6k
Associated Insertion(s)
Carried in Construct
P{UAS-S6k.U}
Also Known As
UAS-S6K
Key Links
Transgenic product class
wild_type
(FlyBase Curators, 2025-)
Mutagen
    Nature of the Allele
    Transgenic product class
    wild_type
    (FlyBase Curators, 2025-)
    Mutagen
    Progenitor genotype
    Carried in construct
    P{UAS-S6k.U}
    Cytology
    Description

    UAS regulatory sequences drive expression of S6k

    (FlyBase Curators, 2025-)

    FlyBase curator comment: this entry represents a transgenic construct where the particular construct used cannot be determined.

    (FlyBase Curators, 2025-)
    Allele components
    Component
    Use(s)
    Regulatory region(s)
    UAS
    Encoded product / tool
    S6k
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 1 )
        Disease
        Interaction
        References
        ameliorates  tauopathy
        modeled by Hsap\MAPTGMR.Ex.PJ
        (Bakhoum et al., 2014)
        exacerbates  Parkinson's disease 6
        modeled by Pink1RNAi.UAS.cYa
        (Liu and Lu, 2010)
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Expression of S6kScer\UAS.cUa under the control of Scer\GAL4e16A results in a significant increase in trichome density in the wing.

        (Das et al., 2014)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Suppressor of
        Phenotype Manifest In
        Suppressor of
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Expression of S6kScer\UAS.cUa suppresses the reduction in trichome density seen in the wings of flies expressing trblScer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4e16A. The resulting flies exhibit a significant increase in trichome density, as is seen in S6kScer\UAS.cUa alone.

        (Das et al., 2014)
        Xenogenetic Interactions
        Statement
        Reference

        The rough eye phenotype characteristic for Hsap\MAPTGMR.Ex.PJ-expressing adult flies is strongly suppressed by co-expression of any of S6kScer\UAS.cUa under the control of Scer\GAL4GMR.PU.

        (Bakhoum et al., 2014)
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        S6kScer\UAS.cUa
        S6kUAS.cUa
        Name Synonyms
        Secondary FlyBase IDs
          References (7)