FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\TrpγUAS.cAa
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General Information
Symbol
Dmel\TrpγUAS.cAa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Akitake
FlyBase ID
FBal0318081
Feature type
allele
Associated gene
Dmel\Trpγ
Associated Insertion(s)
Carried in Construct
P{UAS-Trpγ.A}
Also Known As
UAS-trpγ
Key Links
Transgenic product class
wild_type
(Akitake et al., 2015)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Akitake et al., 2015)
Mutagen
in vitro construct
(Akitake et al., 2015)
Progenitor genotype
Carried in construct
P{UAS-Trpγ.A}
Cytology
Description

UASt regulatory sequences drive expression of the Trpγ coding sequence.

(Akitake et al., 2015)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Trpγ
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      TrpγUAS.cAa/Scer\GAL4Trpγ-G4 rescues TrpγG4

      (Akitake et al., 2015)

      TrpγUAS.cAa/Scer\GAL4Trpγ-G4 rescues Trpγ1/TrpγG4

      (Akitake et al., 2015)

      TrpγUAS.cAa/Scer\GAL4iav.PU rescues Trpγ1

      (Akitake et al., 2015)

      TrpγUAS.cAa/Scer\GAL4elav.PU rescues Trpγ1

      (Akitake et al., 2015)
      Partially rescues

      TrpγUAS.cAa/Scer\GAL4nompA.cK partially rescues Trpγ1

      (Akitake et al., 2015)
      Fails to rescue

      TrpγUAS.cAa/Scer\GAL4nompC.PP fails to rescue Trpγ1

      (Akitake et al., 2015)
      Comments

      Expression of TrpγScer\UAS.cAa under the control of Scer\GAL4Trpγ-G4 rescues the increase in time required to complete the righting reflex which is seen in TrpγG4 flies.

      Expression of TrpγScer\UAS.cAa under the control of Scer\GAL4iav.PU, but not Scer\GAL4nompC.PP, in Trpγ1 flies rescues the action potential frequency of tibial extensor muscles in response to tibia deflections to wild type.

      Expression of TrpγScer\UAS.cAa under the control of Scer\GAL4Trpγ-G4 in TrpγG4/Trpγ1 flies rescues the action potential frequency of tibial extensor muscles in response to tibia deflections to wild type and also rescues their ability to successfully traverse large gaps of 3.5mm to wild-type levels.

      Expression of TrpγScer\UAS.cAa under the control of either Scer\GAL4elav.PU or Scer\GAL4iav.PU (neuronal drivers) rescues the reduced ability of Trpγ1 flies to successfully traverse large gaps of 3.5mm compared to controls. The defect is partially rescued if TrpγScer\UAS.cAa expression is driven by Scer\GAL4nompA.cK.

      (Akitake et al., 2015)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      TrpγScer\UAS.cAa
      TrpγUAS.cAa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Akitake
      Secondary FlyBase IDs
        References (3)