FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\PcbUAS.cYa
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General Information
Symbol
Dmel\PcbUAS.cYa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Yamazaki
FlyBase ID
FBal0318366
Feature type
allele
Associated gene
Dmel\Pcb
Associated Insertion(s)
Carried in Construct
P{UAS-Pcb.Y}
Key Links
Transgenic product class
wild_type
(Yamazaki et al., 2014)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Yamazaki et al., 2014)
Mutagen
in vitro construct
(Yamazaki et al., 2014)
Progenitor genotype
Carried in construct
P{UAS-Pcb.Y}
Cytology
Description

UAS regulatory sequences drive expression of the PCB coding region.

(Yamazaki et al., 2014)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Pcb
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Overexpressing PCBScer\UAS.cYa in glia (using Scer\GAL4nrv2.PU or Scer\GAL4repo.PU) disrupts 1hr memory in young flies, but does not disrupt anesthesia-resistant memory (using Scer\GAL4nrv2.PU).

      (Yamazaki et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Scer\GAL4repo.PU/PcbUAS.cYa is a suppressor of abnormal memory | adult stage phenotype of Pka-C1B3

      (Yamazaki et al., 2014)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Overexpression of PCBScer\UAS.cYa in glia (Scer\GAL4repo.PU) restores age-related memory impairment in Pka-C1B3/+ flies.

      (Yamazaki et al., 2014)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4nrv2.PU/PcbUAS.cYa rescues PcbEP2547/PCB[+]

      (Yamazaki et al., 2014)

      Scer\GAL4repo.PU/PcbUAS.cYa rescues PcbEP2547/PCB[+]

      (Yamazaki et al., 2014)

      Scer\GAL4AtpĪ±-GSG3285-1/PcbUAS.cYa rescues PcbEP2547/PCB[+]

      (Yamazaki et al., 2014)
      Fails to rescue

      Scer\GAL4elav.PU/PcbUAS.cYa fails to rescue PcbEP2547/PCB[+]

      (Yamazaki et al., 2014)
      Comments

      Age-related memory impairment (AMI) is restored by expressing PCBScer\UAS.cYa with glial drivers (Scer\GAL4repo.PU or Scer\GAL4nrv2.PU) but not a neuronal driver (Scer\GAL4elav.PU) in PCBEP2547/+ flies.

      PCBScer\UAS.cYa driven by Scer\GAL4AtpĪ±-GSG3285-1 in the presence of RU486 rescues PCBEP2547/+ AMI when PCBScer\UAS.cYa expression is induced acutely during adult (but not larval) stages.

      (Yamazaki et al., 2014)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      PCBScer\UAS.cYa
      PCBUAS.cYa
      PcbUAS.cYa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Yamazaki
      Secondary FlyBase IDs
        References (1)