FlyBase Allele Report: Dmel\Akt[52]

General Information

Symbol

Dmel\Akt⁵²

Species

D. melanogaster

Name

FlyBase ID

FBal0318385

Feature type

allele

Associated gene

Dmel\Akt

Associated Insertion(s)

P{PZ-Δ52}Akt⁵²

Carried in Construct

Key Links

Allele class

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

Mutagen

Delta2-3 transposase

(Slade and Staveley, 2015)

Progenitor genotype

Associated Insertion(s)

P{PZ-Δ52}Akt⁵²

Cytology

Description

A 9532bp internal deletion of the P{PZ} element in P{PZ}Akt1⁰⁴²²⁶.

(Slade and Staveley, 2015)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate | recessive

(Slade and Staveley, 2015)

Phenotype Manifest In

eye

(Slade and Staveley, 2015)

eye | somatic clone

(Slade and Staveley, 2015)

ommatidium

(Slade and Staveley, 2015)

ommatidium | somatic clone

(Slade and Staveley, 2015)

Detailed Description

Statement

Reference

Emergence of homozygous Akt1⁵² mutant flies is delayed by two to four days compared with controls.

The eyes of Akt1⁵² mutant flies exhibit a decrease in both ommatidial number and size compared with controls. The ommatidia in Akt1⁵² mutant eye clones are reduced in size compared to the homozygous flies.

(Slade and Staveley, 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

Akt⁵² has eye phenotype, enhanceable by foxo²⁵

(Slade and Staveley, 2015)

Akt⁵² has ommatidium phenotype, enhanceable by foxo²⁵

(Slade and Staveley, 2015)

Suppressed by

Statement

Reference

Akt⁵² has eye phenotype, suppressible by foxo²⁵

(Slade and Staveley, 2015)

Akt⁵² has ommatidium phenotype, suppressible | partially by foxo²⁵

(Slade and Staveley, 2015)

Enhancer of

Statement

Reference

Akt⁵² is an enhancer of eye phenotype of foxo²⁵

(Slade and Staveley, 2015)

Akt⁵² is an enhancer of ommatidium phenotype of foxo²⁵

(Slade and Staveley, 2015)

NOT Suppressor of

Statement

Reference

Akt⁵² is a non-suppressor of eye phenotype of foxo²⁵

(Slade and Staveley, 2015)

Akt⁵² is a non-suppressor of ommatidium phenotype of foxo²⁵

(Slade and Staveley, 2015)

Additional Comments

Genetic Interactions

Statement

Reference

The reduction in ommatidium area seen in either mutant alone is enhanced in Akt1⁵² foxo²⁵ double mutant flies. As in the foxo²⁵ mutant alone, ommatidium number is increased.

(Slade and Staveley, 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

Akt⁵² is partially rescued by Scer\GAL4^arm.PU/Akt^UAS.cSa

(Slade and Staveley, 2015)

Comments

Expression of Akt1^Scer\UAS.cSa under the control of Scer\GAL4^arm.PU partially rescues the reductions in ommatidial size and number seen in homozygous Akt1⁵² mutant flies.

(Slade and Staveley, 2015)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Akt1⁵²

(Slade and Staveley, 2015)

Akt⁵²

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

Open Close