FlyBase Allele Report: Dmel\Cbp53E[Mi22]

General Information

Symbol

Dmel\Cbp53E^Mi22

Species

D. melanogaster

Name

FlyBase ID

FBal0318473

Feature type

allele

Associated gene

Dmel\Cbp53E

Associated Insertion(s)

Mi{5'ET1}Cbp53E^Mi22

Carried in Construct

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

minos activity

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Hagel et al., 2015)

Mutagen

minos activity

(Hagel et al., 2015)

Progenitor genotype

Mi{ET1}Cbp53E^MB00150

(Hagel et al., 2015)

Associated Insertion(s)

Mi{5'ET1}Cbp53E^Mi22

Cytology

Description

Mobilisation of the Mi{ET1}Cbp53E^MB00150 insertion which has deleted approximately 7.6kb of the 3' end of the original Mi{ET1} transposon, without affecting Cbp53E sequences.

(Hagel et al., 2015)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | third instar larval stage

(Hagel et al., 2015)

abnormal neuroanatomy | third instar larval stage (with Cbp53E^Mi41)

(Hagel et al., 2015)

abnormal neuroanatomy | third instar larval stage (with Df(2R)ED2751)

(Hagel et al., 2015)

viable

(Hagel et al., 2015)

Phenotype Manifest In

Detailed Description

Statement

Reference

There is no difference in the number of type II/III/Ib synaptic boutons between controls and Cbp53E^Mi22/Cbp53E^Mi22. There is significantly increased axonal branching of type II, III and Ib terminals in Cbp53E^Mi22/Cbp53E^Mi22, Cbp53E^Mi22/Cbp53E^Mi41 or Df(2R)ED2751/Cbp53E^Mi22 larval neuromuscular junctions compared to wild type.

(Hagel et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Cbp53E^Mi22 is rescued by Cbp53E^UAS.cHa/Scer\GAL4^elav.PU

(Hagel et al., 2015)

Cbp53E^Mi22 is rescued by Cbp53E^UAS.cHa/Scer\GAL4^how-24B

(Hagel et al., 2015)

Comments

Cbp53E^Scer\UAS.cHa driven by Scer\GAL4^elav.PU or Scer\GAL4^how-24B rescues increased axon branching at type II/III/Ib terminals seen in Cbp53E^Mi22/Cbp53E^Mi22 larval neuromuscular junctions.

(Hagel et al., 2015)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Cbp53E^Mi22

(Jetti et al., 2023, Hagel et al., 2015)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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