FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Wdr62Δ2a
Open Close
General Information
Symbol
Dmel\Wdr62Δ2a
Species
D. melanogaster
Name
FlyBase ID
FBal0318557
Feature type
allele
Associated gene
Dmel\Wdr62
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
FLPase
(Ramdas Nair et al., 2016)
Progenitor genotype
PBac{PB}Wdr62c04508
(Ramdas Nair et al., 2016)
PBac{PB}Wdr62c04728
(Ramdas Nair et al., 2016)
Cytology
Description

Deletion of part of Wdr62. Generated by FLP-mediated recombination between the PBac{PB}Wdr62c04508 and PBac{PB}Wdr62c04728 progenitor insertions.

(Ramdas Nair et al., 2016)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2L:1,904,480..1,914,165 [+]
Comment:

Inferred boundaries of a deletion generated by FLP-mediated recombination between the PBac{PB}Wdr62c04508 and PBac{PB}Wdr62c04728 progenitor insertions, which removes the upstream-most coding exon from most Wdr62 isoforms.

(Ramdas Nair et al., 2016)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  microcephaly
      CEA
      (Ramdas Nair et al., 2016)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Wdr62Δ2a/Df(2L)Exel8005 is somewhat lethal at the pupal stage, with around 50% adult escapers.

      Loss of microtubule-organizing center (MTOC) activity on the apical centrosome during interphase leads to two centrioles devoid of microtubules in Wdr62Δ2a/Df(2L)Exel8005 third instar larval neuroblasts.

      Wdr62Δ2a/Df(2L)Exel8005 third instar larval neuroblasts display a centrosome asymmetry phenotype, with weaker microtubule intensity on maturing centrosome and metaphase spindles compared to wild type.

      In Wdr62Δ2a/Df(2L)Exel8005 third instar larval neuroblasts the apical centrosome is no longer stationary and shows a more widespread distribution (often maturing close to basal cortex), and both track length and overall centrosome displacement is similar in apical and basal centrioles; track length is significantly increased in the apical and basal centriole and centrosome displacement is significantly larger in the apical centriole compared to wild type.

      Wdr62Δ2a/Df(2L)Exel8005 third instar larval neuroblasts contain misaligned spindles with low frequencies, along with incorrectly positioned centrosomes leading to mild centrosome segregation defects.

      (Ramdas Nair et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Df(2L)Exel8005/Wdr62Δ2a is rescued by Scer\GAL4wor.PU/Wdr62UAS.Dendra2

      (Ramdas Nair et al., 2016)
      Comments

      Expression of Wdr62Scer\UAS.T:Zzzz\dendGFP-Dendra2 driven by Scer\GAL4wor.PU rescues the centrosome asymmetry phenotype (weaker microtubule intensity on maturing centrosome and metaphase spindles) seen in Wdr62Δ2a/Df(2L)Exel8005 third instar larval neuroblasts.

      (Ramdas Nair et al., 2016)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Wdr62Δ2a
      wdr62Δ2a
      (Ramdas Nair et al., 2016)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)