FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Wdr62UAS.Dendra2
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General Information
Symbol
Dmel\Wdr62UAS.Dendra2
Species
D. melanogaster
Name
FlyBase ID
FBal0318558
Feature type
allele
Associated gene
Dmel\Wdr62
Associated Insertion(s)
Carried in Construct
PBac{UAS-Wdr62.mDendra2}
Key Links
Transgenic product class
cDNA
(Ramdas Nair et al., 2016)
wild_type
(Ramdas Nair et al., 2016)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Ramdas Nair et al., 2016)
wild_type
(Ramdas Nair et al., 2016)
Mutagen
in vitro construct
(Ramdas Nair et al., 2016)
Progenitor genotype
Carried in construct
PBac{UAS-Wdr62.mDendra2}
Cytology
Description

UASt regulatory sequences drive expression of the longest Wdr62 isoform (derived from cDNA clone LD01189). The protein is tagged at the C-terminal end with Dendra2.

(Ramdas Nair et al., 2016)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Wdr62
Tagged with
Dendra2
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Third instar larval neuroblasts expressing Wdr62Scer\UAS.T:Zzzz\dendGFP-Dendra2 driven by Scer\GAL4wor.PU are less sensitive to cold, responding with a decreased number of depolymerized microtubules during interphase and increased microtubule regrowth following cold exposure compared to wild type.

      (Ramdas Nair et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4wor.PU/Wdr62UAS.Dendra2 rescues Df(2L)Exel8005/Wdr62Δ2a

      (Ramdas Nair et al., 2016)
      Comments

      Expression of Wdr62Scer\UAS.T:Zzzz\dendGFP-Dendra2 driven by Scer\GAL4wor.PU rescues the centrosome asymmetry phenotype (weaker microtubule intensity on maturing centrosome and metaphase spindles) seen in Wdr62Δ2a/Df(2L)Exel8005 third instar larval neuroblasts.

      (Ramdas Nair et al., 2016)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Wdr62Scer\UAS.T:DspSSAL-2002\GFP-Dendra2
      Wdr62Scer\UAS.T:Zzzz\dendGFP-Dendra2
      Wdr62UAS.Dendra2
      Name Synonyms
      Secondary FlyBase IDs
        References (2)