FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Acf7
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General Information
Symbol
Dmel\Acf7
Species
D. melanogaster
Name
FlyBase ID
FBal0318808
Feature type
allele
Associated gene
Dmel\Acf
Associated Insertion(s)
?{}Acf7
Carried in Construct
Also Known As
acf17
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Jain et al., 2015)
Mutagen
P-element activity
(Jain et al., 2015)
Progenitor genotype
P{EP}AcfEP1181
(Börner et al., 2016)
Associated Insertion(s)
?{}Acf7
Cytology
Description

3098bp deletion ( 3R:31794683..31797780 ) spanning from the P{EP}AcfEP1181 insertion site in the first Acf intron through to the third exon. Generated by imprecise excision of P{EP}AcfEP1181. 34bp (CATGATGAAATATCTGAAATATCAATGAAATGTC) of unknown origin is inserted into the site of the deletion.

(Börner et al., 2016)

Deletion of sequence encoding Acf amino acid residues 41-951.

(Jain et al., 2015)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3R:31,794,683..31,797,780 [+]
Comment:

A 3,089 bp deletion resulting from the imprecise excision of P{EP}AcfEP1181 that maps to 3R:31794683-31797780 . 34 bp of unidentified sequence (CATGATGAAATATCTGAAATATCAATGAAATGTC) is inserted at the site of the deletion.

(Börner et al., 2016)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Acf7/Acf7 mutant females display a significant reduction in egg laying. A subset of Acf7/Acf7 mutant ovarioles display degeneration of the most posterior egg chamber, as shown by increased apoptosis in both oocyte and nurse cells, but no chromatin or chromosome morphology defects are detected, as compared to wild type. Oogenesis appears normal in the germarium and in stages 3-6. Acf7/Acf7 mutant egg chambers do not exhibit packaging defects.

      Acf7/Df(3R)BSC687 mutants display egg chamber apoptosis defects.

      Expression of AcfC.T:Scer\TY1,T:Avic\GFP-EGFP,T:Zzzz\FLAG induces egg chamber cell packaging defects, including compound egg chambers, in Acf7/Acf7 mutants.

      (Börner et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Acf17
      (Börner et al., 2016)
      Acf7
      (Baldi et al., 2018, Scacchetti et al., 2018)
      acf17
      (Jain et al., 2015)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)