FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Sirt1UAS.cPa
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General Information
Symbol
Dmel\Sirt1UAS.cPa
Species
D. melanogaster
Name
FlyBase ID
FBal0319148
Feature type
allele
Associated gene
Dmel\Sirt1
Associated Insertion(s)
Carried in Construct
P{UAS-Sirt1.P}
Key Links
Transgenic product class
wild_type
(Palu and Thummel, 2016)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Palu and Thummel, 2016)
Mutagen
in vitro construct
(Palu and Thummel, 2016)
Progenitor genotype
Carried in construct
P{UAS-Sirt1.P}
Cytology
Description

UASt regulatory sequences drive expression of the Sirt1 coding region.

(Palu and Thummel, 2016)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Sirt1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Overexpression of Sirt1Scer\UAS.cPa driven in the fat body by Scer\GAL4r4 (but not when driven by Scer\GAL4Mef2.PR or Scer\GAL4Ilp2.215-1) significantly reduces relative triglyceride/protein levels compared to wild type.

      (Palu and Thummel, 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Sirt1UAS.cPa/Scer\GAL4r4 rescues Sirt14.5/Sirt12A-7-11

      (Palu and Thummel, 2016)
      Fails to rescue

      Sirt1UAS.cPa/Scer\GAL4Mef2.PR fails to rescue Sirt14.5/Sirt12A-7-11

      (Palu and Thummel, 2016)

      Sirt1UAS.cPa/Scer\GAL4Ilp2.215-1 fails to rescue Sirt14.5/Sirt12A-7-11

      (Palu and Thummel, 2016)
      Comments

      Expression of Sirt1Scer\UAS.cPa driven in the fat body by Scer\GAL4r4 (but not when driven by Scer\GAL4Mef2.PR or Scer\GAL4Ilp2.215-1) rescues insulin signaling in peripheral tissues of Sirt14.5/Sirt12A-7-11 flies.

      (Palu and Thummel, 2016)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Sirt1Scer\UAS.cPa
      Sirt1UAS.cPa
      Name Synonyms
      Secondary FlyBase IDs
        References (1)