FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Dscam1C2.4.2-6.14-9.24-17.2
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General Information
Symbol
Dmel\Dscam1C2.4.2-6.14-9.24-17.2
Species
D. melanogaster
Name
FlyBase ID
FBal0321628
Feature type
allele
Associated gene
Dmel\Dscam1
Associated Insertion(s)
Carried in Construct
P{Dscam1.C2.4.2-6.14-9.24-17.2}
Key Links
Transgenic product class
wild_type
(Huang et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Huang et al., 2011)
Mutagen
in vitro construct
(Huang et al., 2011)
Progenitor genotype
Carried in construct
P{Dscam1.C2.4.2-6.14-9.24-17.2}
Cytology
Description

A 4.5kb Dscam1 promoter fragment drives expression of a cDNA (exons 3-17) - genomic DNA (exons 18-24) hybrid sequence encoding a Dscam1 isoform. The sequence contains alternative exons 4.2, 6.14, and 9.24 (ectodomain) and alternative exon 17.2 (transmembrane domain).

(Huang et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
Dscam1
Encoded product / tool
Dscam1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Down syndrome
      modeled by Dscam121, Dscam1B17-1
      (Huang et al., 2011)
      modeled by Dscam118
      (Huang et al., 2011)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Surviving adults of Dscam121/Dscam1B17-1 mutants expressing Dscam1C2.4.2-6.14-9.24-17.2, or both Dscam1B1.4.2-6.18-9.22-17.1 and Dscam1C2.4.2-6.14-9.24-17.2, are largely immobile, have unexpanded wings, and die a few days after eclosion. The mushroom bodies in these adults exhibit abnormal morphology, with either no lobes or only one lobe projecting medially or dorsally.

      (Huang et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of both Hsap\DSCAMDscam1.WT and Dscam1C2.4.2-6.14-9.24-17.2, or both Hsap\DSCAML1Dscam1.WT and Dscam1C2.4.2-6.14-9.24-17.2, substantially rescues the lethality of Dscam121/Dscam1B17-1 mutants, with a majority of mutants developing to late pupal stages.

      (Huang et al., 2011)
      Complementation and Rescue Data
      Partially rescues

      Dscam1C2.4.2-6.14-9.24-17.2 partially rescues Dscam121/Dscam1B17-1

      (Huang et al., 2011)

      Dscam1C2.4.2-6.14-9.24-17.2/Dscam1B1.4.2-6.18-9.22-17.1 partially rescues Dscam121/Dscam1B17-1

      (Huang et al., 2011)

      Dscam1B2.4.2-6.18-9.22-17.2/Dscam1C2.4.2-6.14-9.24-17.2 partially rescues Dscam121/Dscam1B17-1

      (Huang et al., 2011)

      Dscam1C2.4.2-6.14-9.24-17.2/Dscam1C1.4.2-6.14-9.24-17.1 partially rescues Dscam121/Dscam1B17-1

      (Huang et al., 2011)

      Dscam1C2.4.2-6.14-9.24-17.2 partially rescues Dscam118

      (Huang et al., 2011)
      Comments

      Expression of Dscam1C2.4.2-6.14-9.24-17.2 partially rescues the lethality of Dscam121/Dscam1B17-1 mutants, with an increased proportion of mutants developing to late pupal stage, and a small number of adults emerging, but fails to rescue the dendritic arborization neuron self-avoidance defects of Dscam121/Dscam1B17-1 mutants.

      Expression of Dscam1C2.4.2-6.14-9.24-17.2 partially rescues the axon segregation and additional sister branch defects of Dscam118/Dscam118 late pupal MB neuron clones.

      Expression of both Dscam1B1.4.2-6.18-9.22-17.1 and Dscam1B2.4.2-6.18-9.22-17.2, or both Dscam1B1.4.2-6.18-9.22-17.1 and Dscam1C2.4.2-6.14-9.24-17.2, or both Dscam1C1.4.2-6.14-9.24-17.1 and Dscam1C2.4.2-6.14-9.24-17.2, almost completely rescues the lethality of Dscam121/Dscam1B17-1 mutants, with most mutants developing to pupal stage.

      Expression of Dscam1B2.4.2-6.18-9.22-17.2, or both Dscam1B2.4.2-6.18-9.22-17.2 and Dscam1C2.4.2-6.14-9.24-17.2, partially rescues the lethality of Dscam121/Dscam1B17-1 mutants, with an increased proportion of mutants developing to late pupal stage, and a small number of adults emerging.

      (Huang et al., 2011)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Dscam1C2.4.2-6.14-9.24-17.2
      Name Synonyms
      Secondary FlyBase IDs
        References (1)